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Receptors and Reflexes of the Respiratory Tract

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Pulmonary Biology in Health and Disease

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Abstract

The upper airway comprises the extrathoracic portion of the airway and includes the nose, the nasopharynx, the oropharynx, the larynx, and the cranial half of the trachea. The upper airway has respiratory and nonrespiratory functions: the latter includes olfaction, air conditioning, chewing, swallowing, and vocalization. Some of these functions are sometimes in conflict with breathing and a well-developed control mechanism is often required to overcome these difficulties.

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References

  • Anderson, J.W., Sant’Ambrogio, F.B., Mathew, O.P., and Sant’Ambrogio, G. (1990a) Waterresponsive laryngeal receptors in the dog are not specialized endings. Respir. Physiol. 79, 33–44.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, J.W., Sant’Ambrogio, F.B., Orani, G.P., Sant’Ambrogio, G, and Mathew, O.P. (1990b) Carbon dioxide-responsive laryngeal receptors in the dog. Respir. Physiol. 82, 217–226.

    Article  PubMed  CAS  Google Scholar 

  • Bartlett, D., Jr., Jeffery, P., Sant’Ambrogio, G., and Wise, J.C.M. (1976) Location of stretch receptors in the trachea and bronchi of the dog. J. Physiol. (Lond.) 258, 409–420.

    Google Scholar 

  • Bartlett, D., Jr., and Sant’Ambrogio, G. (1976) Effect of local and systemic hypercapnia on the discharge of stretch receptors in the airways of the dog. Respir. Physiol. 26, 91–99.

    Article  PubMed  Google Scholar 

  • Bradley, G.W., Noble, M.I.M., and Trenchard, D. (1976) The direct effect on pulmonary stretch receptors discharge produced by changing CO2 concentration in dogs on cardiopulmonary bypass and its action on breathing. J. Physiol. (Lond.) 261, 359–373.

    CAS  Google Scholar 

  • Coleridge, H.M., and Coleridge, J.C.G. (1986) Reflexes evoked from tracheobronchial tree and lungs. In: Handbook of physiology. Section 3: the respiratory system, vol. II. control of breathing, part 1. Cherniack, N.S., and Widdicombe, J.G. (eds.) pp. 395–429. American Physiological Society, Bethesda.

    Google Scholar 

  • Coleridge, H.M., Coleridge, J.C.G., Baker, D.G., Ginzel, K.H., and Morrison, M. A. (1978a) Comparison of the effects of histamine and prostaglandin on afferent C-fiber endings and irritant receptors in the intrapulmonary airways. Adv. Exp. Med. Biol. 99, 291–305.

    PubMed  CAS  Google Scholar 

  • Coleridge, H.M., Coleridge, J.C.G., and Banzett, R.B. (1978b) Effect of CO2 on afferent vagal endings in the canine lung. Respir. Physiol. 34, 135–141.

    Article  PubMed  CAS  Google Scholar 

  • Coleridge, J.C.G., and Coleridge, H.M. (1984) Afferent vagal C fibres innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99, 1–110.

    Article  PubMed  CAS  Google Scholar 

  • dimming, G., and Semple, S.J. (1973) Disorders of the respiratory system. Chapter one. Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • Das, R.M., Jeffery, P.K., and Widdicombe, J.G. (1979) Experimental degeneration of intraepithelial nerve fibers in cat airways. J. Anat. 128, 259–267.

    PubMed  CAS  Google Scholar 

  • Davies, A., Sant’Ambrogio, F.B., and Sant’Ambrogio, G. (1980) Control of postural changes of end expiratory volume (FRC) by airways slowly adapting mechanoreceptors. Respir. Physiol. 41, 211–216.

    Article  PubMed  CAS  Google Scholar 

  • Euler von, C. (1986) Brain stem mechanisms for generation and control of breathing pattern. In: Handbook of physiology. Section 3: the respiratory system, vol. II, control of breathing Cherniack, N.S., and Widdicombe, J.G. (eds.) pp. 1–67. American Physiological Society, Bethesda.

    Google Scholar 

  • Fisher, J.T., and Mortola, J.P. (1980) Statics of the respiratory system in newborn mammals. Respir. Physiol. 41, 155–172.

    Article  PubMed  CAS  Google Scholar 

  • Fisher, J.T., Sant’Ambrogio, F.B., and Sant’Ambrogio, G. (1983) Stimulation of tracheal slowly adapting stretch receptors by hypercapnia and hypoxia. Respir. Physiol. 53, 525–339.

    Article  Google Scholar 

  • Fisher, J.T., and Sant’Ambrogio, G. (1982) Location and discharge properties of respiratory vagal afferents in the newborn dog. Respir. Physiol. 50, 209–220.

    Article  PubMed  CAS  Google Scholar 

  • Fleming, P.J., Goncalves, A.L., Levine, M.R., and Woollard, S. (1984) The development of stability of respiration in human infants: changes in ventilatory responses to spontaneous sighs. J. Physiol. (Lond.) 347, 1–16.

    CAS  Google Scholar 

  • Fox, B., Bull, T.B., and Guz, A. (1980) Innervation of alveolar walls in the human lung: an electron microscopic study. J. Anat. 131, 683–692.

    PubMed  CAS  Google Scholar 

  • Glogowska, M., Richardson, P.S., Widdicombe, J.G, and Winning, A.J. (1972) The role of the vagus nerves, peripheral chemoreceptors, and other afferent pathways on the genesis of augmented breaths in cats and rabbits. Respir. Physiol. 16, 179–196.

    Article  PubMed  CAS  Google Scholar 

  • Green, J.F., Schertel, E.R., Coleridge, H.M., and Coleridge, J.C.D. (1986) Effect of pulmonary arterial Pco2 on slowly adapting pulmonary stretch receptors. J. Appl. Physiol. 60, 2048–2055.

    PubMed  CAS  Google Scholar 

  • Guz, A., and Trenchard, D. (1971) Pulmonary stretch receptor activity in man: a comparison with dog and cat. J. Physiol. (Lond.) 213, 329–343.

    CAS  Google Scholar 

  • Hamilton, R.D., Winning, A.J., and Guz, A. (1987) Blockade of “alveolar” and airway reflexes by local anesthetic aerosols in dogs. Respir. Physiol. 67, 159–170.

    Article  PubMed  CAS  Google Scholar 

  • Horner, R.L., Innes, J.A., Murphy, K., and Guz, A. (1991) Evidence for reflex upper airway dilator muscle activation by sudden negative pressure in man. J. Physiol. (Lond.) 436, 15–29.

    CAS  Google Scholar 

  • Hung, K.S., Hertweck, M.S., Hardy, J.D., and Loosli, C.G. (1972) Innervation of nervesand asso of the mouse lung: an electron microscopic study. Am. J. Anat. 135, 477–496.

    Article  PubMed  CAS  Google Scholar 

  • Hung, K.S., Hertweck, M.S., Hardy, J.D., and Loosli, C.G. (1973) Ultrastructure of nerves and associated cells in bronchiolar epithelium of the mouse lung. J. Ultrastr. Res. 43, 426–437.

    Article  CAS  Google Scholar 

  • Jammes, Y., Fornaris, E., Mei, N., and Barrat, E. (1982) Afferent and efferent components of the bronchial vagal branches in cats. J. Auton. Nerv. Syst. 5, 165–176.

    Article  PubMed  CAS  Google Scholar 

  • Jammes, Y., Barthelemy, P., and Delpierre, S. (1983) Respiratory effects of cold air breathing in anesthetized cats. Respir. Physiol. 54, 41–54.

    Article  PubMed  CAS  Google Scholar 

  • Kappagoda, C.T., and Ravi, K. (1989) Plasmapheresis affects responses of slowly and rapidly adapting receptors to pulmonary venous congestion in dogs. J. Physiol. 416, 79–91.

    PubMed  CAS  Google Scholar 

  • Karlsson, J.-A., Sant’Ambrogio, G., and Widdicombe, J. (1988) Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol. 65, 1007–1023.

    PubMed  CAS  Google Scholar 

  • Keller, E., Kohl, J., and Koller, E.A. (1989) Location of pulmonary stretch receptors in the guinea pig. Respir. Physiol. 76, 149–158.

    Article  PubMed  CAS  Google Scholar 

  • Korpás, J., and Tomori, Z. (1979) Cough and other respiratory reflexes, Karger, S. Basel.

    Google Scholar 

  • Kostreva, D.R., Hopp, F.A., Zuperku, E.J., Igler, F.O., Coon, R.L., and Kampine, XP (1978) Respiratory inhibition with sympathetic afferent stimulation in canine and primate. J. Appl. Physiol. 44, 718–724.

    PubMed  CAS  Google Scholar 

  • Kostreva, D.R., Zuperku, E.J., Hess, G.L., Coon, R.L., and Kampine, J.P. (1975) Pulmonary afferent activity recorded from sympathetic nerves. J. Appl. Physiol. 39, 37–40.

    PubMed  CAS  Google Scholar 

  • Krauhs, J.M. (1984) Morphology of presumptive slowly adapting receptors in dog trachea. Anat. Rec. 210, 73–85.

    Article  PubMed  CAS  Google Scholar 

  • Lee, B.-P, Sant’Ambrogio, G., and Sant’Ambrogio, F.B. (1992) Afferent innervation and receptors of the canine extrathoracic trachea. Respir. Physiol. 90, 55–65.

    Article  PubMed  CAS  Google Scholar 

  • Lundberg, J.M. (1990) Peptide and classical transmitter mechanisms in the autonomic nervous system. Arch. Int. Pharmacodyn. 303, 9–19.

    PubMed  CAS  Google Scholar 

  • Marlot, D., and Duron, B. (1979) Postnatal development of vagal control of breathing in the kitten. J. Physiol. (Paris) 75, 891–900.

    CAS  Google Scholar 

  • Mortola, J.P, and Sant’Ambrogio, G. (1979) Mechanics of the trachea and behaviour of its slowly adapting stretch receptors. J. Physiol. (Lond.) 286, 577–590.

    CAS  Google Scholar 

  • Nishino, T., Anderson, J.W., and Sant’Ambrogio, G. (1993) Effects of halothane, enflurane, and isoflurane on laryngeal receptors in dogs. Respir. Physiol. 91, 247–260.

    Article  PubMed  CAS  Google Scholar 

  • Nolan, P., Bradford, A., O’Regan, R.G., and McKeogh, D. (1990) The effects of changes in laryngeal airway CO2 concentration on genioglossus muscle activity in the anaesthetized cat. Exp. Physiol. 70, 2080–2086.

    Google Scholar 

  • Orani, G.P., Anderson, J.W., Sant’Ambrogio, G., and Sant’Ambrogio, E.B. (1991) Upper airway cooling and l-menthol reduce ventilation in the guinea pig. J. Appl. Physiol. 70, 2080–2086.

    PubMed  CAS  Google Scholar 

  • Pack, R.J., Al-Ugaily, L.H., and Widdicombe, J.G. (1984) The innervation of the trachea and extrapulmonary bronchi of the mouse. Cell Tissue Res. 238, 61–68.

    Article  PubMed  CAS  Google Scholar 

  • Paintal, A.S. (1969) Mechanism of stimulation of type J. pulmonary receptors. J. Physiol. (Lond.) 203, 511–532.

    CAS  Google Scholar 

  • Pisarri, T.E., Xonzon, A., Coleridge, H.M., and Coleridge, J.C.G (1992) Vagal afferent and reflex responses to changes in surface osmolarity in lower airways of dogs. J. Appl. Physiol. 73, 2305–2313.

    PubMed  CAS  Google Scholar 

  • Pisarri, T.E., Yu, J., Coleridge, H.M., and Coleridge, J.C.G. (1986) Background activity in pulmonary vagal C-fibers and its effects on breathing. Respir. Physiol. 64, 29–43.

    Article  PubMed  CAS  Google Scholar 

  • Ravi, K. (1986) Distribution and location of slowly adapting pulmonary stretch receptors in the airways of cats. J. Auton. Nerv. Syst. 15, 205–216.

    Article  PubMed  CAS  Google Scholar 

  • Robinson, N.P, Venning, L., Kyle, H., and Widdicombe, J.G. (1986) Quantitation of the secretory cells of the ferret tracheobronchial tree. J. Anat. 145, 173–188.

    PubMed  CAS  Google Scholar 

  • Rhodin, J.A.G. (1966) Ultrastructure and function of the human tracheal mucosa. Am. Rev. Respir. Dis. 93, 1–15.

    PubMed  Google Scholar 

  • Sampson, S.R., and Vidruk, E.H. (1977) Chemical stimulation of rapidly adapting receptors in the airways. In: The regulation of respiration during sleep and anesthesia, Fitzgerald, R.S., Gautier, H., and Lahiri, S. (eds.) pp. 281–290. Plenum, New York.

    Google Scholar 

  • Sant’Ambrogio, G. (1982) Information arising from the tracheobronchial tree of mammals. Physiol. Rev. 62, 531–569.

    PubMed  CAS  Google Scholar 

  • Sant’Ambrogio, G., and Mortola, J.P. (1977) Behavior of slowly adapting stretch receptors in the extrathoracic trachea of the dog. Respir. Physiol. 31, 377–385.

    Article  PubMed  CAS  Google Scholar 

  • Sant’Ambrogio, G., Remmers, J.E., De Groot, W.J., Callas, G., and Mortola, J.P. (1978) Localization of rapidly adapting receptors in the trachea and main stem bronchus of the dog. Respir. Physiol. 33, 359–366.

    PubMed  CAS  Google Scholar 

  • Sant’Ambrogio, G., Tsubone, H., and Sant’Ambrogio, F.B. (1995) Sensory information from the upper airway: role in the control of breathing. Respir. Physiol. 102, 1–16.

    Article  PubMed  CAS  Google Scholar 

  • Sellick, H., and Widdicombe, J.G. (1970) Vagal deflation and inflation reflexes mediated by lung irritant receptors. Q. J. Exp. Physiol. 55, 153–163.

    Google Scholar 

  • Tatar, M., Webber, S.E., and Widdicombe, J.G. (1988) Lung C-fibre activation and defensive reflexes in anaesthetized cats. J. Physiol. (Lond.) 402, 411–420.

    CAS  Google Scholar 

  • Trenchard, D. (1986) CO2/H+ receptors in the lungs of anesthetized rabbits. Respir. Physiol. 63, 397–402.

    Article  Google Scholar 

  • Vidruk, E.H., Hahn, H.L., Nadel, J.A., and Sampson, S.R. (1977) Mechanisms by which histamine stimulates rapidly adapting receptors in dog lung. J. Appl. Physiol. 43, 397–402.

    PubMed  CAS  Google Scholar 

  • Widdicombe, J.G. (1961) Respiratory reflexes in man and other mammalian species. Clin. Sci. 21, 163–170.

    PubMed  CAS  Google Scholar 

  • Widdicombe, J.G., and Sant’Ambrogio, G. (1992) Mechanoreceptors in respiratory systems. In: Adv. compar. and environ. physiol., vol. 10. Ito, F. (ed.) pp. 111–135. Springer-Verlag, Berlin.

    Google Scholar 

Recommended Readings

  • Bartlett, D., Jr., Jeffery, P., Sant’Ambrogio, G., and Wise, J.C.M. (1976) Location of stretch receptors in the trachea and bronchi of the dog. J. Physiol. (Lond.) 258, 409–420.

    Google Scholar 

  • Coleridge, H.M., and Coleridge, J.C.G (1986) Reflexes evoked from tracheobronchial tree and lungs. In: Handbook of physiology. Section 3: the respiratory system, vol. II, control of breathing, part 1, Cherniack, N.S., and Widdicombe, J.G. (eds.) pp. 395–429. American Physiological Society, Bethesda.

    Google Scholar 

  • Goldie, R.G., Rigby, P.J., Fernandes, L.B., and Henry, P.J. (2001) The impact of inflammation on bronchial neuronal networks. Pulm. Pharmacol. Ther. 14, 177–182.

    Article  PubMed  CAS  Google Scholar 

  • Karlsson, J.-A., Sant’Ambrogio, G., and Widdicombe, J. (1988) Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol. 65, 1007–1023.

    PubMed  CAS  Google Scholar 

  • Mortola, J.P., and Sant’Ambrogio, G. (1979) Mechanics of the trachea and behaviour of its slowly adapting stretch receptors. J. Physiol. (Lond.) 286, 577–590.

    CAS  Google Scholar 

  • Pierce, R.J., and Worsnop, C.J. (1999) Upper airway function and dysfunction in respiration. Clin. Exp. Pharmacol. Physiol. 26, 1–10.

    Article  PubMed  CAS  Google Scholar 

  • Sant’Ambrogio, G. (1982) Information arising from the tracheobronchial tree of mammals. Physiol. Rev. 62, 531–569.

    PubMed  CAS  Google Scholar 

  • Sant’Ambrogio, G., Tsubone, H., and Sant’Ambrogio, F.B. (1995) Sensory information from the upper airway: role in the control of breathing. Respir. Physiol. 102, 1–16.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Giuseppe Sant’ Ambrogio
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Editors and Affiliations

  1. Department of Physiology, University of Wisconsin Medical School, Madison, WI, 53706, USA

    E. Edward Bittar MD

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Ambrogio, G.S. (2002). Receptors and Reflexes of the Respiratory Tract. In: Bittar, E.E. (eds) Pulmonary Biology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-0-387-22435-0_5

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  • DOI: https://doi.org/10.1007/978-0-387-22435-0_5

  • Publisher Name: Springer, New York, NY

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