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Inhaled Noninfectious Toxicants and Their Effects on the Lung

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Pulmonary Biology in Health and Disease

Abstract

The primary function of the respiratory system is to bring in air and allow gas diffusion to the blood through a thin barrier. Our air unfortunately contains more than the desired diffusible gases and nitrogen. Particles and inorganic and organic molecules come in contact with various parts of the respiratory system. Most of these substances are benign and exhaled or readily cleared but some are toxic. The damage done by inhaled toxicants appear in several forms. It may be as predictable as a chemical reaction, or as variable as an idiosyncratic allergic reaction, the injury may be immediate or delayed, and the damage may require large or small amounts of toxicants. An overview of the common inhaled toxicants and their effects on the lungs will be given. Texts of environmental medicine and reviews of individual agents will provide more detailed information.

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References

  • Balaan, M.R., and Banks, D.E. (1998) Silicosis. In: Rom, W.N. (ed.) pp. 435–448. Environmental and Occupational Medicine. Third ed. Lippincott-Raven, Philadelphia.

    Google Scholar 

  • Becker, R.P., and Geoffroy, J.S. (1981) Backscattered electron imaging for the life sciences: introduction and index to applications. Scan. Electron Microscop. 4, 195–206.

    CAS  Google Scholar 

  • Blount, B.W. (1990) Two types of metal fume fever: mild vs. serious. Mil. Med. 155, 372–377.

    PubMed  CAS  Google Scholar 

  • Chaffey, CM., and Bowie, C. (1994) Radon and health-an update. J. Publ. Health Med. 16, 465–470.

    CAS  Google Scholar 

  • Chan-Yeung, M., and Malo, J.L. (1995) Occupational asthma. N. Engl. J. Med. 333, 107–112.

    Article  PubMed  CAS  Google Scholar 

  • Churg, A. (1983) Nonasbestos pulmonary mineral fibers in the general population. Environ. Res. 31, 189–200.

    Article  PubMed  CAS  Google Scholar 

  • Churg, A., and Warnock, M.L. (1979) Analysis of the cores of asbestos bodies from members of the general population: patients with probable low-degree exposure to asbestos. Am. Rev. Respir. Dis. 120, 781–786.

    PubMed  CAS  Google Scholar 

  • Churg, A., Wright, J., Wiggs, B., and Depaoli, L. (1990) Mineralogic parameters related to amosite asbestos-induced fibrosis in humans. Am. Rev. Respir. Dis. 142(6 Pt. 1), 1331–1336.

    PubMed  CAS  Google Scholar 

  • Churg, A.M., and Warnock, M.L. (1979) Analysis of the cores of ferruginous (asbestos) bodies from the general population. III. Patients with environmental exposure. Lab. Inv. 40, 622–626.

    CAS  Google Scholar 

  • Cormier, Y. (1998) Hypersensitivity pneumonitis. In: Rom, W.N. (ed.) pp. 457–465. Environmental and Occupational Medicine. Lippincott-Raven, Philadelphia.

    Google Scholar 

  • Dragovic, T., Schraufnagel, D.E., Becker, R.P, Sekosan, M., Votta-Velis, E.G., and Erdös, E.G. (1995) Carboxypeptidase M activity is increased in bronchoalveolar lavage in human lung disease. Am. J. Respir. Cell Mol. Biol. 152, 760–764.

    CAS  Google Scholar 

  • Farrell, F.J. (1987) Angioedema and urticaria as acute-and late-phase reactions to zinc fume exposure, with associated metal fume fever-like symptoms. Am. J. Ind. Med. 12, 331–337.

    Article  PubMed  CAS  Google Scholar 

  • Gaston, B., Drazen, J.M., Loscalzo, J., and Stamler, J.S. (1994) The biology of nitrogen oxides in the airways. Am. X Respir. Crit. Care Med. 149(2 Pt. 1), 538–551.

    CAS  Google Scholar 

  • Hall, T.A. (1988) Capabilities and limitations of probe methods for the microanalysis of chemical elements in biology: a brief introduction. Ultramicroscopy 24, 181–184.

    Article  PubMed  CAS  Google Scholar 

  • Xackman, H.L., Tan, F., Schraufnagel, D., Dragovic, T, Dezsö, B., Becker, R.P, and Erdös, E.G. (1995) Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 13, 196–204.

    Google Scholar 

  • Xederlinic, P.J., Abraham, J.L., Churg, A., Himmelstein, J.S., Epier, G.R., and Gaensler, E.A. (1990) Pulmonary fibrosis in aluminum oxide workers. Investigation of nine workers, with pathologic examination and microanalysis in three of them. Am. Rev. Respir. Dis. 142, 1179–1184.

    Google Scholar 

  • Kaufmann, A.F., McDade, J.E., Patton, CM., et al. (1981) Pontiac fever: isolation of the etiologic agent (Legionella pneumophila) and demonstration of its mode of transmission. Am. J. Epidemiol. 114, 337–347.

    PubMed  CAS  Google Scholar 

  • Logan, WPD. (1953) Mortality in London fog incident. Lancet 1, 336–338.

    Article  PubMed  CAS  Google Scholar 

  • McClellan, R.O., and Henderson, R.F. (1995) Concepts in inhalation toxicology. McClellan, R.O., and Henderson, R.F. (eds.) Taylor and Francis, Philadelphia.

    Google Scholar 

  • Morrow, P.E., Utell, M.J., Pauer, M.A., Speers, D.M., and Gibb, F.R. (1993) Effects of near ambient levels of sulfuric acid aerosol on lung function in exercising subjects with asthma and COPD. Ann. Occup. Hyg. 38, 933.

    Google Scholar 

  • Nordman, H., Keskinen, H., and Tuppurainen, M. (1985) Formaldehyde asthma-rare or overlooked? J. Allergy Clin. Immunol. 75, 91–99.

    Article  PubMed  CAS  Google Scholar 

  • O’Neill, S., Lesperance, E., and Klass, D.J. (1984) Rat lung lavage surfactant enhances bacterial phagocytosis and intracellular killing by alveolar macrophages. Am. Rev. Respir. Dis. 130, 225–230.

    PubMed  CAS  Google Scholar 

  • Rode, L.E., Ophus, E.M., and Gylseth, B. (1981) Massive pulmonary deposition of rutile after titanium dioxide exposure: Light-microscopical and physico-analytical methods in pigment identification. Acta Pathol. Microbiol. Scand. [A] 89, 455–461.

    CAS  Google Scholar 

  • Roggli, V.L. (1989) Scanning electron microscopic analysis of mineral fibers in human lungs. In: Ingram, P., Shelburne, J.D., and Roggli, V.L. (eds.) pp. 97–110. Microprobe Analysis in Medicine. Hemisphere, New York.

    Google Scholar 

  • Roggli, V.L., and Brody, A.R. (1988) Imaging techniques for application to lung toxicology. In: Gardener, D.E., Crapo, J.D., and Massaro, E.J. (eds.) pp. 117–145. Toxicology of the Lung. Raven Press, New York.

    Google Scholar 

  • Roggli, V.L., Pratt, PC, and Brody, A.R. (1992) Analysis of tissue mineral fiber content. In: Roggli, V.L., Greenberg, S.D., and Pratt, P.C. (eds.) pp. 299–339. Pathology of Asbestos-associated Diseases. Little, Brown, Boston.

    Google Scholar 

  • Roggli, V.L., Pratt, P.C., and Brody, A.R. (1993) Asbestos fiber type in malignant mesothelioma: an analytical scanning electron microscopic study of 94 cases. Am. J. Ind. Med. 23(4), 605–614.

    Article  PubMed  CAS  Google Scholar 

  • Rose, C.S., Martyny, J.W., Newman, L.S., Milton, D.K., King, T.E., Beebe, J.L., et al. (1999) “Life-guard lung”: endemic granulomatosis pneumonitis in an indoor swimming pool. Am. J. Publ. Health 88, 1785–1800.

    Google Scholar 

  • Rylander, R., Haglind, P., and Lundholdm, M. (1985) Endotoxin in cotton dust and respiratory function decrement among cotton workers in an experimental cardroom. Am. Rev. Respir. Dis. 131, 209–213.

    PubMed  CAS  Google Scholar 

  • Sandoval, J., Salas, J., Martinez-Guerra, M.L., Gomez, A., Martinez, C, Portales, A., et al. (1993) Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation. Chest 103, 12–20.

    PubMed  CAS  Google Scholar 

  • Schraufnagel, D.E., Roggli, V.L., Ingram, P., and Shelburne, J. (1990) An introduction to analytical electron microscopy. In: Schraufnagel, D.E. (ed.) pp. 1–46. Electron microscopy of the lung. Marcel Dekker, New York.

    Google Scholar 

  • Sheppard, D.A., Saisho, A., Nadel, J.A., and Boushey, H.A. (1981) Exercise increases sulfur dioxide induced bronchocontriction in asthmatic subjects. Am. Rev. Respir. Dis. 123, 486–491.

    PubMed  CAS  Google Scholar 

  • Shrenk, H.H., Heimann, H., Clayton, G.D., Gafafen, W., and Wexler, H. (1949) Air pollution in Donora, Pennsylvania: epidemiology of the unusual smog episodes of October 1948. Publ. Health Ser. Bull. 306. (Complete Vol.)

    Google Scholar 

  • Shusterman, D., and Neal, E. (1986) Prolonged fever associated with inhalation of multiple pyrolysis products. Ann. Emerg. Med. 15, 831–833.

    Article  PubMed  CAS  Google Scholar 

  • Spengler, J.D., Treitman, R.D., Tosteson, T., Mage, D.T., and Soczek, M.L. (1985) Personal exposure to respirable particulates and implications for air pollution epidemiology. Environ. Sei. Technol. 19, 700–707.

    Article  CAS  Google Scholar 

  • Utell, M.X (1993) Particulate air pollution and health. New evidence on an old problem. Am. Rev. Respir. Dis. 148, 1334–1335.

    Google Scholar 

  • Xu, X., and Wang, L. (1993) Association of indoor and outdoor particulate level with chronic respiratory illness. Am. Rev. Respir. Dis. 148, 1516–1522.

    PubMed  CAS  Google Scholar 

  • Yao, T.T., Wang, N.S., Michel, R.P, and Poulsen, R.S. (1984) Mineral dusts in lungs with scar or scar cancer. Cancer 54, 1814–1823.

    Article  PubMed  CAS  Google Scholar 

Recommended Readings

  • Adamson, I.Y., Prieditis, H., and Vincent, T.R. (1999) Pulmonary toxicology of an atmospheric particulate sample is due to the soluble fraction. Toxic. Appl. Pharmacol. 157, 43–50.

    Article  PubMed  CAS  Google Scholar 

  • Crapo, J.D., McClennan, R.D., and Gardner, D.E. (1999) Toxicology of the lung. Third ed. Taylor and Francis, Philadelphia.

    Google Scholar 

  • Swift, D., and Foster, W.M. (1999) Air pollutants and the respiratory tract. Marcel Dekker, New York.

    Google Scholar 

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Schraufnagel, D.E., Goel, S., Wang, NS. (2002). Inhaled Noninfectious Toxicants and Their Effects on the Lung. In: Bittar, E.E. (eds) Pulmonary Biology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-0-387-22435-0_22

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  • DOI: https://doi.org/10.1007/978-0-387-22435-0_22

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-95215-4

  • Online ISBN: 978-0-387-22435-0

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