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The Pulmonary Circulation in Health and Disease

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Pulmonary Biology in Health and Disease

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Abstract

Control of blood flow through the pulmonary circulation is unique for several reasons. Unlike other organs, the lungs must accept the entire cardiac output. Despite receiving the entire cardiac output, pulmonary artery pressure must remain low to allow the exchange of oxygen and carbon dioxide across the thin layer of cells separating the capillaries and the alveoli. The maintenance of this low pressure circulation is dependent upon the metabolically active pulmonary vascular endothelium and the production of vasoactive mediators. Endothelial dysfunction can result in alterations in pulmonary vascular tone, pulmonary hypertension, or alterations in vascular permeability, pulmonary edema. The critical role of the endothelium in the maintenance of vascular tone and integrity will be discussed in this chapter.

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Authors
  1. Martin Tristani-Firouzi
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  2. Stephen L. Archer
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  3. E. Kenneth Weir
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Editors and Affiliations

  1. Department of Physiology, University of Wisconsin Medical School, Madison, WI, 53706, USA

    E. Edward Bittar MD

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Tristani-Firouzi, M., Archer, S.L., Kenneth Weir, E. (2002). The Pulmonary Circulation in Health and Disease. In: Bittar, E.E. (eds) Pulmonary Biology in Health and Disease. Springer, New York, NY. https://doi.org/10.1007/978-0-387-22435-0_11

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