It is well known that after you have stayed awake for a number of hours you will get tired and sleepy. You may fight the urge to close your eyes and sleep, but with time the pull toward doing so increases and the desire to release into sleep becomes overpowering. Having done allnight experiments in which it is imperative to remain not only awake but also alert, I can personally attest to the difficulty of this task between 2 a.m. and 6 a.m. It is as if something—let’s call it a chemical factor or a hormone*—builds up and causes this effect, and the longer you stay awake the more this chemical accumulates, making the effort of staying awake more difficult. Then when one eventually does sleep, this chemical dissipates, and likewise the drive to sleep.
KeywordsAdenosine Receptor Chemical Factor Basal Forebrain Preoptic Area Growth Hormone Release Hormone
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