Disorders of Sleep and Waking



Wilse Webb, emeritus professor of psychology at the University of Florida and a pioneer in sleep research, distinguished between sleep disturbances and sleep disorders. The former are “disturbances of normal and healthy sleep patterns that may or may not impact waking performance.… Sleep disorders (are) clinically diagnosable conditions of the sleep/waking system that require therapeutic intervention” (Webb, 1992, p. 80).


Obstructive Sleep Apnea Sleep Apnea Sleep Disorder Sudden Infant Death Syndrome Excessive Daytime Sleepiness 
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  1. It is of some interest to know how these exotic names were chosen. “Orexin” was used because early studies indicated that in rats, this peptide stimulated appetite, and the Greek root of the word literally means that. The term “hypocretin” is based on the findings that cells that synthesize the peptide are located in the hypothalamus and that the amino acid sequence is similar to that of the gut peptide secretin. Recent work has shown that nearly all the hypothalamic neurons that synthesize orexin (hypocretin) colocalize (also contain) another peptide transmitter, dynorphin. There is evidence that the narcolepsy influence is due to orexin and that feeding is regulated by dynorphin (Chou et al., 2001).Google Scholar

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© Springer-Verlag New York, Inc. 2002

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