Abstract
Large cell undifferentiated carcinomas (LCUD), which are also called simply large cell carcinomas, are malignant neoplasms of the lung that show no squamous, glandular, or small cell (neuroendocrine) differentiation in routinely stained sections of the tissues or smears of the cytologic specimens. Extensive sampling of the tumors may exhibit focal differentiating features. The term non-small cell carcinoma is also popularly used in order to separate the neoplasm from the category of small cell carcinoma because of the distinctive management modalities. Large cell undifferentiated carcinomas ultrastructurally demonstrate squamous or glandular features or both in majority of the tumors. A small proportion of these neoplasms demonstrate neurosecretory granules, and only a few LCUDs lack any differentiating features.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliography
Barbazza R, Toniolo L, Pinarello A, et al. Accuracy of bronchial aspiration cytology in typing operable (stage I-II) pulmonary carcinoma. Diagn Cytopathol 1992; 8: 3 - 7.
Carter D, Patchefsky AS. Tumors and Tumor-Like Lesions of the Lung, volume 36. Major Problems in Pathology. Philadelphia: W.B. Saunders, 1998.
Chow LTC, Chow WH, Wilson MS, et al. Fine-needle aspiration cytologic diagnosis of lymphoepithelioma-like carcinoma of the lung. Report of two cases with immunohistochemical study. Am J Clin Pathol 1995; 103: 35 - 40.
Colby TV, Koss MN, Travis WD. Tumors of the Lower Respiratory Tract, third series, fascicle 13. Washington, D.C.: AFIP, 1995.
Dail DH, Hammar SP. Pulmonary Pathology, second edition. New York: Springer-Verlag, 1993.
Delmonte VC, Alberti O, Saldiva PHN. Large cell carcinoma of the lung. Ultrastructural and immunohistochemical features. Chest 1986; 90: 524 - 527.
Linnoila I. Pathology of non-small cell lung cancer. Hematol Oncol Clin North Am 1990; 4: 1027 - 1051.
Matsui K, Kitagawa M, Wakaki K, et al. Lung carcinoma mimicking malignant lymphoma. Report of three cases. Acta Pathol Jpn 1993; 43: 608 - 614.
Mennemeyer R, Hammar SP, Bauermeister DE, et al. Cytologic, histologic and electron microscopic correlations in poorly differentiated primary lung carcinomas. A study of 43 cases. Acta Cytol 1979; 23: 297 - 302.
Moore WJ, Dewar A, Springall D, et al. Non-small cell lung carcinoma with neuroendocrine features. A light microscopic, immunohistochemical and ultrastructural study of 11 cases. Histopathology 1988; 13: 329 - 337.
Schulte MA, Ramxy I, Greenberg SD. Immunocytochemical characterization of large cell carcinomas of the lung. Role, limitations and technical considerations. Acta Cytol 1991; 35: 175 - 179.
Travis WD, Colby TV, Corrin B, et al. Histologic Typing of Lung and Pleural Tumors, third edition. World Health Organization. Berlin: Springer-Verlag, 1999.
Visscher DW, Zarbo RJ, Trojanowski JQ, et al. Neuroendocrine differentiation in poorly differentiated lung carcinoma. A light microscopic and immunohistologic study. Mod Pathol 1990; 3: 508 - 512.
Zusman-Harach SB, Harach HR, Gibbs AR. Cytological features of non-small cell carcinomas of the lung in fine needle aspirates. J Clin Pathol 1991; 44: 997 - 1002.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag New York, Inc.
About this chapter
Cite this chapter
Kini, S.R. (2002). Large Cell Undifferentiated Carcinoma. In: Color Atlas of Pulmonary Cytopathology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-21641-6_9
Download citation
DOI: https://doi.org/10.1007/978-0-387-21641-6_9
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-2977-8
Online ISBN: 978-0-387-21641-6
eBook Packages: Springer Book Archive