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To find out whether E. coli really knows what it is doing, Ed Purcell and I thought hard about the theory of chemoreception—I was the straight man—and concluded that its cells can sense temporal gradients about as well as any other device of similar size could possibly do (Berg and Purcell, 1977). And then my students and I looked more closely at how changes in tumble probability actually depend on the concentrations of attractants or repellents.
KeywordsImpulse Response Negative Stimulus Bacterial Chemotaxis Equal Increment Inert Marker
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