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Syphilis

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The endemic treponematoses are a group of chronic diseases affecting primarily the skin of children and young adults who live in remote, impoverished areas between the tropics of Cancer and Capricorn. They are considered as a group because they have many clinical, pathological, and epidemiological features in common (see Table 1). They are also caused by spirochetes that are closely related to one another and to Treponema pallidum subsp. pallidum of venereal syphilis.(1) These diseases with their etiologic treponeme in order of their worldwide prevalence are yaws (T. pallidum subsp. pertenue), endemic syphilis (T. pallidum subsp. endemicum), and pinta (Treponema carateum).

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Notes

  1. 1.

    The authors would like to thank Peter L. Perine, MD, who passed away in 2003, for the initial groundwork of this chapter.

References

  1. Miao, R. M., & Fieldsteel, A. H. (1980). Genetic relationship between Treponema pallidum and Treponema pertenue, two noncultivable human pathogens. J. Bacteriol., 144, 427–429

    Google Scholar 

  2. Smibert, R. M. (1984). Treponema. In N. R. Kreig & J. C. Holt (Eds.), Bergey’s Manual of Systematic Bacteriology (pp. 50–52). Baltimore: Williams & Wilkins.

    Google Scholar 

  3. Rothschild, B. M., & Rothschild, C. (1995). Treponemal disease revisited: skeletal discrimination of yaws, bejel, and venereal syphilis. Clin. Infect. Dis., 20, 1402–1408.

    Article  PubMed  CAS  Google Scholar 

  4. Hudson, E. H. (1965). Treponematosis in perspective. Bull. World Health Org., 32, 735–748.

    PubMed  CAS  Google Scholar 

  5. Hackett, C. J. (1963). On the origin of the human treponematoses. Bull. World Health Org., 29, 7–41.

    PubMed  CAS  Google Scholar 

  6. Antal, G. M, Lukehart, S. A., & Meheus, A. Z. (2002). The endemic treponematoses. Microb. Infect., 4, 83–94.

    Article  Google Scholar 

  7. Miller, J. N. (1973). Immunity in experimental syphilis VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by gamma-irradiation. J. Immunol., 110, 1206–1215.

    PubMed  CAS  Google Scholar 

  8. Turner, T. B., & Hollander, D. H. (1957). Biology of the Treponematoses. World Health Organization, Geneva.

    Google Scholar 

  9. Cameron, C. E., Castro, C., Lukehart, S. A., & Van Voorhis, W. C. (1999). Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strains. Infect. Immun., 67, 3168–3170.

    PubMed  CAS  Google Scholar 

  10. Cameron, C. E., Lukehart, S. A., Castro, C., Molini, B., Godornes, C., & Van Voorhis, W. C. (2000). Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92. J. Infect. Dis., 181, 1401–1413.

    Article  PubMed  CAS  Google Scholar 

  11. Centurion-Lara, A., Castro, C., Castillo, R., Shaffer, J. M., Van Voorhis, W. C., & Lukehart, S. A. (1998). The flanking regions sequences of the 15-kDa lipoprotein gene differentiate pathogenic treponemes. J. Infect. Dis., 177, 1036–1040.

    PubMed  CAS  Google Scholar 

  12. Guthe, T., & Luger, A. (1966). The control of endemic syphilis of childhood. Dermatol. Int., 5, 179–199.

    Article  Google Scholar 

  13. Janssens, P. G. (1985). Research: the prerequisite for innovative strategies and technologies. Rev. Infect. Dis., 7 Suppl. 2, S289–S294.

    Article  PubMed  Google Scholar 

  14. Antal, G. M., & Causse, G. (1985). The control of endemic treponematoses. Rev. Infect. Dis., 7 Suppl. 2, S220–S226.

    Article  PubMed  Google Scholar 

  15. Guthe, T., & Willcox, R. R. (1954). Treponematoses: a world problem. WHO Chronicle, 8, 37–113.

    Google Scholar 

  16. World Health Organization. (1986). Endemic treponematoses. Week. Epidemiol. Rec., 61, 198–202.

    Google Scholar 

  17. International symposium on yaws and other endemic treponematoses, Washington, D. C. (1985). Rev. Infect. Dis., 7 Suppl., S217–S351.

    Google Scholar 

  18. Proceedings of the inter-regional meeting on yaws and other endemic treponematoses, Cipanas, Indonesia. (1986). Southeast Asian J. Trop. Med. Public Health, 17 Suppl., 1–96.

    Google Scholar 

  19. World Health Organization. (1986). Report on a regional meeting on yaws and other endemic treponematoses, Brazzaville. Unpublished summary document.

    Google Scholar 

  20. Roman, G. C., & Roman, L. N. (1986). Occurrence of congenital, cardiovascular, visceral, neurologic and neuro-ophthalmologic complications in late yaws; a theme for future research. Rev. Infect. Dis., 8, 760–770.

    Article  PubMed  CAS  Google Scholar 

  21. Weller, C. V. (1937). The visceral pathology in Haitian treponematoses. Am. J. Syph. Gonorrhea Vener. Dis., 21, 357–369.

    Google Scholar 

  22. Perine, P. L., Hopkins, D. R., Niemel, P. L. A., St. John, R. K., Causse, G., & Antal, G. M. (1984). Handbook of Endemic Treponematoses, World Health Organization, Geneva.

    Google Scholar 

  23. Talhari, S., & Talhari, C. (2006). Endemic treponematoses. In S.K. Tyring, O. Lupi, & U.R. Hengge (Eds.), Tropical Dermatology (pp. 335–343). Philadelphia: Elsevier Inc.

    Google Scholar 

  24. Magnuson, H. J., Eagle, H., & Fleischman, R. (1948). The minimal infectious inoculum of Spirocheaeta pallidum (Nichols strain) and a consideration of its rate of multiplication in vivo. Am. J. Syph., 32, 1–18.

    CAS  Google Scholar 

  25. Backhouse, J. L., Hudson, B. J., Hamilton, P. A., & Nesteroff, S. I. (1998). Failure of penicillin treatment of yaws on Karkar Island, Papua New Guinea. Am. J. Trop. Med. Hyg., 59, 388–392.

    PubMed  CAS  Google Scholar 

  26. Anselmi, M., Araujo, E., Narvaez, A., Cooper, P. J., & Guderian, R. H. (1995). Yaws in Ecuador: impact of control measures on the disease in the Province of Esmeraldas. Genitourin M., 71, 343–346.

    CAS  Google Scholar 

  27. The World Health Report 1998 – Life in the 21st Century; A vision for all, World Health Organization, Geneva. (1998).

    Google Scholar 

  28. Engelkens, H. J. H., Vuzevski, V. D., & Stolz, E. (1999). Nonvenereal treponematoses in tropical countries. Clinics in Dermatology, 17, 143–152.

    Article  PubMed  CAS  Google Scholar 

  29. Csonka, G., & Pace, J. (1985). Endemic nonvenereal treponematoses (bejel) in Saudi Arabia. Rev. Infect. Dis., 7 Suppl 2, S260–S265.

    Article  PubMed  CAS  Google Scholar 

  30. Talhari, S. (1988). Pinta: Aspectos clinicos, laboratoriais e situacao epidemiologica no estado do Amazonas (PhD Thesis, Escola Paulista de Medicina, Sao Paulo, Brasil, 1988).

    Google Scholar 

  31. Castro, L.G. (1994). Nonvenereal treponematoses. J. Am. Acad. Dermatol., 31, 1075–1076.

    Article  PubMed  CAS  Google Scholar 

  32. Woltsche-Kahr, I., Schmidt B., Aberer W., & Aberer, E. (1999). Pinta in Austria (or Cuba?): Import of an Extinct Disease? Arch. Dermatol., 135(6), 685–688.

    Article  PubMed  CAS  Google Scholar 

  33. Wicher K., Wicher V., Abbruscato F., & Baughn R.E. (2000). Treponema pallidum subsp. pertenue displays pathogenic properties different from those of T. pallidum subsp. pallidum. Infect. Immun., 68, 3219–3225.

    Article  PubMed  CAS  Google Scholar 

  34. Schell R.F., Azedegan A.A., Nitskansky S.G., & LeFrock J.L. (1982). Acquired resistance of hamsters to challenge with homologous and heterologous virulent treponemes. Infect. Immun., 37, 617–621.

    PubMed  CAS  Google Scholar 

Suggested Reading

  • Burke, J. P., Hopkins, D. R., Hume, J. C., Perine, P. L., and St. John, R. (eds.) (1985). International symposium on yaws and other endemic treponematoses, Washington DC, 1984, Rev. Infect. Dis. 8 (Suppl. 2):S217–S351 (1985).

    Google Scholar 

  • Guthe, T., Ridet, J., Vorst, F., D’Costa, J., and Grab, B. (1972). Methods for the surveillance of endemic treponematoses and sero-immunological investigations of “disappearing” diseases, Bull. WHO 46:1–14.

    PubMed  CAS  Google Scholar 

  • Hackett, C. J. (1957). An International Nomenclature of Yaws Lesions, World Health Organization, Geneva (Monograph Series No. 36).

    Google Scholar 

  • Hill, K. R., Kodijat, R., and Sardadi, M. (1954). Atlas of framboesia: A nomenclature and clinical study of the skin lesions, Bull. WHO 4: 201–246.

    Google Scholar 

  • Perine, P. L., Hopkins, D. R., Niemel, P. L. A., St. John, R. K., Causse, G., and Antal, G. M. (1984). Handbook of Endemic Treponematoses, World Health Organization, Geneva.

    Google Scholar 

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Ahmed, A.M., Madkan, V., Brantley, J.S., Mendoza, N., Tyring, S.K. (2009). Syphilis. In: Brachman, P., Abrutyn, E. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09843-2_37

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