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Bacterial Infections of Humans pp 661–676Cite as

Rocky Mountain Spotted Fever

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Rocky Mountain spotted fever is an acute febrile illness transmitted to man by ticks infected with Rickettsia rickettsii. Usually sudden in onset, it is characterized by chills, headache, and fever lasting 2 or more weeks. A characteristic rash appears on the extremities on about the 4th febrile day and spreads to the trunk. The exanthem and other anatomical manifestations result from focal areas of vasculitis and perivascular inflammation scattered throughout the body. Central nervous system (CNS) manifestations of delirium and coma as well as shock and renal failure occur in the severely ill. Serum antibodies to specific rickettsial antigens appear during the 2nd and 3rd weeks of illness. The tetracyclines are highly effective therapeutically.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

    Aaron Milstone

  2. Division of Medical Microbiology, Department of Pathology, Johns Hopkins Medical Institution, Baltimore, Maryland 21205, USA

    J. Stephen Dumler

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  1. Rollins School of Public Health, Emory University, Clifton Road NE., 1518, Atlanta, 30322, U.S.A.

    Philip S. Brachman

  2. College of Medicine, Office of Faculty Affairs, Drexel University, Race Street 1505, Philadelphia, 19102, U.S.A.

    Elias Abrutyn

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Milstone, A., Dumler, J.S. (2009). Rocky Mountain Spotted Fever. In: Brachman, P., Abrutyn, E. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09843-2_31

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