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Helicobacter pylori

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Bacterial Infections of Humans

Helicobacter pylori, a corkscrew-shaped, gram-negative rod, resides in the mucous layer of the human stomach. Unrecognized until the 1980s, the organism is extraordinarily common, infecting at least half of the world’s population. Once acquired, infection persists chronically, typically continuing in the stomach throughout the host’s life. H. pylori infection invariably causes acute and chronic gastric inflammation, but in only a minority of cases does it result in overt clinical disease. Yet, the diseases attributed to H. pylori infection, peptic ulcer disease and gastric malignancy, are among the world’s most important causes of morbidity and mortality in adults. For this reason, the past 30 years have borne witness to furious activity concerning diagnosis, treatment, and prevention of this recently rediscovered pathogen.

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Acknowledgments

The authors would like to thank Jeremy Schneider and Luz Sanchez for their technical assistance.

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Authors and Affiliations

  1. Department of Medicine, Stanford University School of Medicine, Stanford, California, 94305-5407, USA

    Sharon Perry

  2. Department of Medicine, Stanford University School of Medicine, Stanford, California, 94305-5107, USA

    Catherine de Martel

  3. Department of Medicine, Stanford University School of Medicine, Stanford, California, 94305-5107, USA

    Julie Parsonnet

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  1. Sharon Perry
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Correspondence to Sharon Perry .

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  1. Rollins School of Public Health, Emory University, Clifton Road NE., 1518, Atlanta, 30322, U.S.A.

    Philip S. Brachman

  2. College of Medicine, Office of Faculty Affairs, Drexel University, Race Street 1505, Philadelphia, 19102, U.S.A.

    Elias Abrutyn

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Perry, S., de Martel, C., Parsonnet, J. (2009). Helicobacter pylori. In: Brachman, P., Abrutyn, E. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09843-2_18

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