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Gastrointestinal Conditions

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Handbook of Clinical Psychology in Medical Settings

Abstract

In this chapter, we focus on chronic gastrointestinal (GI) conditions commonly seen both in primary care and specialty gastroenterology clinics. In the past decade, much advancement into the understanding of psychosocial factors of both functional and organic GI conditions has been made. Most of these changes have occurred in our understanding of the irritable bowel syndrome (IBS), which is now firmly rooted in the biopsychosocial model and replaces the previous psychosomatic paradigm. Advances in cognitive neuroscience have highlighted the cognitive-affective processes that affect pain and digestive functioning, which in turn have informed psychological interventions. Advances in the understanding of functional GI conditions have led to a dramatic increase in the quality of research into the psychological aspects of chronic organic conditions, such as inflammatory bowel diseases and esophageal conditions.

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References

  1. Talley NJ, Gabriel SE, Harmsen WS, Zinsmeister AR, Evans RW. Medical costs in community subjects with irritable bowel syndrome. Gastroenterology. 1995;109:1736–41.

    CAS  PubMed  Google Scholar 

  2. Spiegel B, Bolus R, Harris LA, et al. Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale. Aliment Pharmacol Ther. 2009;30:1159–70.

    CAS  PubMed Central  PubMed  Google Scholar 

  3. Remes-Troche J, Bernal-Reyes R, Valladares-Lepine M, Alonso-Larraga O, Gomez-Escudero O, Melendez-Mena D. Gastroenterology diagnosis and treatment guidelines of irritable bowel syndrome; clinical features and diagnostic criteria. Rev Gastroenterol Mex. 2009;74:58–62.

    PubMed  Google Scholar 

  4. Quigley EM, Sperber AD, Drossman DA. WGO-Rome foundation joint symposium summary: IBS-the global perspective. J Clin Gastroenterol. 2011;45:i–ii.

    Google Scholar 

  5. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006;130:1480–91.

    PubMed  Google Scholar 

  6. Corazziari E. The Rome criteria for functional gastrointestinal disorders: a critical reappraisal. J Pediatr Gastroenterol Nutr. 2004;39(Suppl3):S754–5.

    PubMed  Google Scholar 

  7. Parfenov AI, Ruchkina IN, Orobei Iu A, Bykova SV. Efficacy oh the Rome criteria II in diagnosis of irritable bowel syndrome. Ter Arkh. 2004;76:51–4.

    Google Scholar 

  8. Kruis W. Diagnosis of functional bowel diseases. Praxis. 2007;96:319–22.

    CAS  PubMed  Google Scholar 

  9. Lee OY, Mayer EA, Schmulson M, Chang L, Naliboff B. Gender-related differences in IBS symptoms. Am J Gastroenterol. 2001;96:2184–93.

    CAS  PubMed  Google Scholar 

  10. Park HJ, Jarrett M, Cain K, Heitkemper M. Psychological distress and GI symptoms are related to severity of bloating in women with irritable bowel syndrome. Res Nurs Health. 2008;31:98–107.

    PubMed  Google Scholar 

  11. Toner BB, Akman D. Gender role and irritable bowel syndrome: literature review and hypothesis. Am J Gastroenterol. 2000;95:11–6.

    CAS  PubMed  Google Scholar 

  12. Karantanos T, Markoutsaki T, Gazouli M, Anagnou NP, Karamanolis DG. Current insights in to the pathophysiology of irritable bowel syndrome. Gut Pathog 2010;2:3.

    PubMed Central  PubMed  Google Scholar 

  13. Camilleri M, Coulie B, Tack JF. Visceral hypersensitivity: facts, speculations, and challenges. Gut. 2001;48:125–31.

    CAS  PubMed Central  PubMed  Google Scholar 

  14. Delvaux M. Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome. Gut. 2002;51(1):i67–71.

    PubMed Central  PubMed  Google Scholar 

  15. Labus JS, Naliboff BD, Berman SM, et al. Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome. Neuroimage. 2009;47:952–60.

    PubMed Central  PubMed  Google Scholar 

  16. Naliboff BD, Berman S, Suyenobu B, et al. Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients. Gastroenterology. 2006;131:352–65.

    PubMed  Google Scholar 

  17. Mayer EA, Berman S, Suyenobu B, et al. Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis. Pain. 2005;115:398–409.

    PubMed  Google Scholar 

  18. Spetalen S, Sandvik L, Blomhoff S, Jacobsen MB. Rectal visceral sensitivity in women with irritable bowel syndrome without psychiatric comorbidity compared with healthy volunteers. Gastroenterol Res Pract. 2009;2009:130684.

    PubMed Central  PubMed  Google Scholar 

  19. Rapps N, van Oudenhove L, Enck P, Aziz Q. Brain imaging of visceral functions in healthy volunteers and IBS patients. J Psychosom Res. 2008;64:599–604.

    PubMed  Google Scholar 

  20. Mayer EA, Aziz Q, Coen S, et al. Brain imaging approaches to the study of functional GI disorders: a Rome working team report. Neurogastroenterol Motil. 2009;21:579–96.

    CAS  PubMed  Google Scholar 

  21. Chang JY, Talley NJ. Current and emerging therapies in irritable bowel syndrome: from pathophysiology to treatment. Trends Pharmacol Sci. 2010;31:326–34.

    CAS  PubMed  Google Scholar 

  22. Sikander A, Rana SV, Prasad KK. Role of serotonin in gastrointestinal motility and irritable bowel syndrome. Clin Chim Acta. 2009;403:47–55.

    CAS  PubMed  Google Scholar 

  23. Clouse RE, Lustman PJ, Geisman RA, Alpers DH. Antidepressant therapy in 138 patients with irritable bowel syndrome: a five-year clinical experience. Aliment Pharmacol Ther. 1994;8:409–16.

    CAS  PubMed  Google Scholar 

  24. Clouse RE. Antidepressants for irritable bowel syndrome. Gut. 2003;52:598–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  25. van der Veek PP, Van Rood YR, Masclee AA. Symptom severity but not psychopathology predicts visceral hypersensitivity in irritable bowel syndrome. Clin Gastroenterol Hepatol. 2008;6:321–8.

    Google Scholar 

  26. Camilleri M, Mayer EA. Developing irritable bowel syndrome guidelines through meta-analyses: does the emperor really have new clothes? Gastroenterology. 2009;137:766–9.

    PubMed  Google Scholar 

  27. Whitehead WE, Palsson OS. Is rectal pain sensitivity a biological marker for irritable bowel syndrome: psychological influences on pain perception. Gastroenterology. 1998;115:1263–71.

    CAS  PubMed  Google Scholar 

  28. Piche M, Arsenault M, Poitras P, Rainville P, Bouin M. Widespread hypersensitivity is related to altered pain inhibition processes in irritable bowel syndrome. Pain. 2010;148:49–58.

    PubMed  Google Scholar 

  29. Guthrie E, Creed F, Fernandes L, et al. Cluster analysis of symptoms and health seeking behaviour differentiates subgroups of patients with severe irritable bowel syndrome. Gut. 2003;52:1616–22.

    CAS  PubMed Central  PubMed  Google Scholar 

  30. Lackner JM, Lou Coad M, Mertz HR, et al. Cognitive therapy for irritable bowel syndrome is associated with reduced limbic activity, GI symptoms, and anxiety. Behav Res Ther. 2006;44:621–38.

    PubMed  Google Scholar 

  31. Mayer EA, Naliboff BD, Chang L. Basic pathophysiologic mechanisms in irritable bowel syndrome. Dig Dis. 2001;19:212–8.

    CAS  PubMed  Google Scholar 

  32. Tache Y, Martinez V, Million M, Maillot C. Role of corticotropin releasing factor receptor subtype 1 in stress-related functional colonic alterations: implications in irritable bowel syndrome. Eur J Surg Suppl. 2002;2002:16–22.

    Google Scholar 

  33. Wang SH, Dong L, Luo JY, et al. A research of migrating motor complex in patients with irritable bowel syndrome. Zhonghua Nei Ke Za Zhi. 2009;48:106–10.

    PubMed  Google Scholar 

  34. Sapolsky RM. Stress, glucocorticoids, and damage to the nervous system: the current state of confusion. Stress. 1996;1:1–19.

    CAS  PubMed  Google Scholar 

  35. Sapolsky RM. Organismal stress and telomeric aging: an unexpected connection. Proc Natl Acad Sci U S A. 2004;101:17323–4.

    CAS  PubMed Central  PubMed  Google Scholar 

  36. Sapolsky RM. Why stress is bad for your brain. Science. 1996;273:749–50.

    CAS  PubMed  Google Scholar 

  37. Videlock EJ, Adeyemo M, Licudine A, et al. Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome. Gastroenterology. 2009;137:1954–62.

    CAS  PubMed Central  PubMed  Google Scholar 

  38. Blanchard EB, Lackner JM, Jaccard J, et al. The role of stress in symptom exacerbation among IBS patients. J Psychosom Res. 2008;64:119–28.

    PubMed  Google Scholar 

  39. Naliboff BD, Kim SE, Bolus R, Bernstein CN, Mayer EA, Chang L. Gastrointestinal and psychological mediators of health-related quality of life in IBS and IBD: a structural equation modeling analysis. Am J Gastroenterol. 2012;107:451–9.

    PubMed  Google Scholar 

  40. Talley NJ, Fett SL, Zinsmeister AR. Self-reported abuse and gastrointestinal disease in outpatients: association with irritable bowel-type symptoms. Am J Gastroenterol 1995;90:366–71.

    CAS  PubMed  Google Scholar 

  41. Blanchard EB, Keefer L, Payne A, Turner SM, Galovski TE. Early abuse, psychiatric diagnoses and irritable bowel syndrome. Behav Res Ther. 2002;40:289–98.

    PubMed  Google Scholar 

  42. Heitkemper MM, Cain KC, Burr RL, Jun SE, Jarrett ME. Is childhood abuse or neglect associated with symptom reports and physiological measures in women with irritable bowel syndrome? Biol Res Nurs. 2011;13:399–408.

    PubMed Central  PubMed  Google Scholar 

  43. Laws A. Sexual abuse history and women’s medical problems. J Gen Intern Med. 1993;8:441–3.

    CAS  PubMed  Google Scholar 

  44. Leserman J, Drossman DA. Sexual and physical abuse history and medical practice. Gen Hosp Psychiatry. 1995;17:71–4.

    CAS  PubMed  Google Scholar 

  45. Wilkie A, Schmidt U. Gynecological pain. In: Blechman EA, Ironwell KD, editors. Behavioral medicine and women: a comprehensive handbook. New York: Guilford Press; 1998.

    Google Scholar 

  46. Patacchioli FR, Angelucci L, Dellerba G, Monnazzi P, Leri O. Actual stress, psychopathology and salivary cortisol levels in the irritable bowel syndrome (IBS). J Endocrinol Invest. 2001;24:173–7.

    CAS  PubMed  Google Scholar 

  47. Irwin C, Falsetti SA, Lydiard RB, Ballenger JC, Brock CD, Brener W. Comorbidity of posttraumatic stress disorder and irritable bowel syndrome. J Clin Psychiatry. 1996;57:576–8.

    CAS  PubMed  Google Scholar 

  48. Thabane M, Marshall JK. Post-infectious irritable bowel syndrome. World J Gastroenterol. 2009;15:3591–6.

    PubMed Central  PubMed  Google Scholar 

  49. Rhodes DY, Wallace M. Post-infectious irritable bowel syndrome. Curr Gastroenterol Rep. 2006;8:327–32.

    PubMed  Google Scholar 

  50. Sertbas Y, Belli H, Piskinpasa N, et al. Assesment of psychiatric symptoms and co-morbidities in patients with irritable bowel syndrome. West Indian Med J. 2012;61:544–8.

    CAS  PubMed  Google Scholar 

  51. Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications? Gastroenterology. 2002;122:1140–56.

    PubMed  Google Scholar 

  52. Gros DF, Antony MM, McCabe RE, Swinson RP. Frequency and severity of the symptoms of irritable bowel syndrome across the anxiety disorders and depression. J Anxiety Disord. 2009;23:290–6.

    PubMed  Google Scholar 

  53. Lydiard RB, Fossey MD, Marsh W, Ballenger JC. Prevalence of psychiatric disorders in patients with irritable bowel syndrome. Psychosomatics. 1993;34:229–34.

    CAS  PubMed  Google Scholar 

  54. Canavan JB, Bennett K, Feely J, O’Morain CA, O’Connor HJ. Significant psychological morbidity occurs in irritable bowel syndrome: a case-control study using a pharmacy reimbursement database. Aliment Pharmacol Ther. 2009;29:440–9.

    CAS  PubMed  Google Scholar 

  55. Kabra N, Nadkarni A. Prevalence of depression and anxiety in irritable bowel syndrome: a clinic based study from India. Indian J Psychiatry. 2013;55:77–80.

    PubMed Central  PubMed  Google Scholar 

  56. Sykes MA, Blanchard EB, Lackner J, Keefer L, Krasner S. Psychopathology in irritable bowel syndrome: support for a psychophysiological model. J Behav Med. 2003;26:361–72.

    PubMed  Google Scholar 

  57. Creed F, Guthrie E, Ratcliffe J, et al. Does psychological treatment help only those patients with severe irritable bowel syndrome who also have a concurrent psychiatric disorder? Aust N Z J Psychiatry. 2005;39:807–15.

    PubMed  Google Scholar 

  58. Miller AR, North CS, Clouse RE, Wetzel RD, Spitznagel EL, Alpers DH. The association of irritable bowel syndrome and somatization disorder. Ann Clin Psychiatry. 2001;13:25–30.

    CAS  PubMed  Google Scholar 

  59. Riedl A, Schmidtmann M, Stengel A, et al. Somatic comorbidities of irritable bowel syndrome: a systematic analysis. J Psychosom Res. 2008;64:573–82.

    PubMed  Google Scholar 

  60. Somatic Symptom Disorders. 2011. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.

    Google Scholar 

  61. Blanchard EB, Scharff L, Schwarz SP, Suls JM, Barlow DH. The role of anxiety and depression in the irritable bowel syndrome. Behav Res Ther. 1990;28:401–5.

    CAS  PubMed  Google Scholar 

  62. Ford AC. Generalized anxiety disorder and irritable bowel syndrome. Aliment Pharmacol Ther. 2009;30:1087–8; author reply 8–9.

    CAS  PubMed  Google Scholar 

  63. Crane C, Martin M. Perceived vulnerability to illness in individuals with irritable bowel syndrome. J Psychosomatic Res. 2002;53:1115–22.

    Google Scholar 

  64. Maunder RG. PD associated with gastrointestinal disease: review and hypotheses. J Psychosomatic Res. 1998;44:91–105.

    CAS  Google Scholar 

  65. Folkman S, Lazarus RS, Gruen RJ, DeLongis A. Appraisal, coping, health status, and psychological symptoms. J Pers Soc Psychol. 1986;50:571–9.

    CAS  PubMed  Google Scholar 

  66. Folkman S, Lazarus RS, Dunkel-Schetter C, DeLongis A, Gruen RJ. Dynamics of a stressful encounter: cognitive appraisal, coping, and encounter outcomes. J Pers Soc Psychol. 1986;50:992–1003.

    CAS  PubMed  Google Scholar 

  67. Lazarus RS. The psychology of stress and coping. Issues Ment Health Nurs. 1985;7:399–418.

    CAS  PubMed  Google Scholar 

  68. Blanchard EB, Keefer L, Galovski TE, Taylor AE, Turner SM. Gender differences in psychological distress among patients with irritable bowel syndrome. J Psychosom Res. 2001;50:271–5.

    CAS  PubMed  Google Scholar 

  69. Whitehead WE, Palsson OS, Levy RR, Feld AD, Turner M, Von Korff M. Comorbidity in irritable bowel syndrome. Am J Gastroenterol. 2007;102:2767–76.

    PubMed  Google Scholar 

  70. Guthrie E, Creed F, Dawson D, Tomenson B. A randomised controlled trial of psychotherapy in patients with refractory irritable bowel syndrome. Br J Psychiatry. 1993;163:315–21.

    CAS  PubMed  Google Scholar 

  71. Porcelli P, Leandro G, De Carne M. Functional gastrointestinal disorders and eating disorders. Relevance of the association in clinical management. Scand J Gastroenterol. 1998;33:577–82.

    CAS  PubMed  Google Scholar 

  72. Tang TN, Toner BB, Stuckless N, Dion KL, Kaplan AS, Ali A. Features of eating disorders in patients with irritable bowel syndrome. J Psychosomatic Res. 1998;45:171–8.

    CAS  Google Scholar 

  73. Perkins SJ, Keville S, Schmidt U, Chalder T. Eating disorders and irritable bowel syndrome: is there a link? J Psychosomatic Res. 2005;59:57–64.

    CAS  Google Scholar 

  74. Levy RL, Whitehead WE, Von Korff MR, Feld AD. Intergenerational transmission of gastrointestinal illness behavior. Am J Gastroenterol. 2000;95:451–6.

    CAS  PubMed  Google Scholar 

  75. Levy RL, Langer SL, Whitehead WE. Social learning contributions to the etiology and treatment of functional abdominal pain and inflammatory bowel disease in children and adults. World J Gastroenterol. 2007;13:2397–403.

    PubMed  Google Scholar 

  76. Chitkara DK, van Tilburg MA, Blois-Martin N, Whitehead WE. Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review. Am J Gastroenterol. 2008;103:765–74; quiz 75.

    PubMed  Google Scholar 

  77. Jones MP, Wessinger S, Crowell MD. Coping strategies and interpersonal support in patients with irritable bowel syndrome and inflammatory bowel disease. Clin Gastroenterol Hepatol. 2006;4:474–81.

    PubMed  Google Scholar 

  78. Lackner JM, Jaccard J, Krasner SS, Katz LA, Gudleski GD, Holroyd K. Self-administered cognitive behavior therapy for moderate to severe irritable bowel syndrome: clinical efficacy, tolerability, feasibility. Clin Gastroenterol Hepatol. 2008;6:899–906.

    PubMed Central  PubMed  Google Scholar 

  79. Lackner JM, Mesmer C, Morley S, Dowzer C, Hamilton S. Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis. J Consult Clin Psychol. 2004;72:1100–13.

    PubMed  Google Scholar 

  80. Sullivan G, Blewett AE, Jenkins PL, Allison MC. Eating attitudes and the irritable bowel syndrome. Gen Hosp Psychiatry. 1997;19:62–4.

    CAS  PubMed  Google Scholar 

  81. Strough J, Patrick JH, Swenson LM, Cheng S, Barnes KA. Collaborative everyday problem solving: interpersonal relationships and problem dimensions. Int J Aging Hum Dev. 2003;56:43–66.

    PubMed  Google Scholar 

  82. Cheng C, Hui W, Lam S. Perceptual style and behavioral pattern of individuals with functional gastrointestinal disorders. Health Psychol. 2000;19:146–54.

    CAS  PubMed  Google Scholar 

  83. Cheng C, Hui WM, Lam SK. Coping style of individuals with functional dyspepsia. Psychosom Med. 1999;61:789–95.

    CAS  PubMed  Google Scholar 

  84. Camilleri M. Do the symptom-based, Rome criteria of irritable bowel syndrome lead to better diagnosis and treatment outcomes? The Con argument. Clin Gastroenterol Hepatol. 2009;8:129.

    PubMed Central  PubMed  Google Scholar 

  85. Schmulson M, Noble-Lugo A, Valenzuela-de la Cueva V, De Arino-Suarez M, Guillermo-Denis L, Ramos-Narvaez F. Gastroenterology diagnosis and treatment guidelines of irritable bowel syndrome; treatment. Rev Gastroenterol Mex. 2009;74:63–70.

    PubMed  Google Scholar 

  86. Ford AC, Talley NJ, Spiegel BM, et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ. 2008;337:a2313.

    PubMed Central  PubMed  Google Scholar 

  87. Pimentel M, Park S, Mirocha J, Kane SV, Kong Y. The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Intern Med. 2006;145:557–63.

    PubMed  Google Scholar 

  88. Fumi AL, Trexler K. Rifaximin treatment for symptoms of irritable bowel syndrome. Ann Pharmacother. 2008;42:408–12.

    CAS  PubMed  Google Scholar 

  89. DiPalma JA, DeRidder PH, Orlando RC, Kolts BE, Cleveland MB. A randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycol laxative. Am J Gastroenterol. 2000;95:446–50.

    CAS  PubMed  Google Scholar 

  90. Brenner DM, Chey WD. Bifidobacterium infantis 35624: a novel probiotic for the treatment of irritable bowel syndrome. Rev Gastroenterol Disord. 2009;9:7–15.

    PubMed  Google Scholar 

  91. Whelan K, Quigley EM. Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease. Curr Opin Gastroenterol. 2013;29:184–9.

    PubMed  Google Scholar 

  92. Hosseini A, Nikfar S, Abdollahi M. Are probiotics effective in management of irritable bowel syndrome? Arch Med Sci. 2012;8:403–5.

    PubMed Central  PubMed  Google Scholar 

  93. Moayyedi P, Ford AC, Talley NJ, et al. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut. 2010;59:325–32.

    CAS  PubMed  Google Scholar 

  94. Brenner DM, Moeller MJ, Chey WD, Schoenfeld PS. The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review. Am J Gastroenterol. 2009;104:1033–49; quiz 50.

    CAS  PubMed  Google Scholar 

  95. Galmiche JP, Clouse RE, Balint A, et al. Functional esophageal disorders. Gastroenterology. 2006;130:1459–65.

    PubMed  Google Scholar 

  96. Camilleri M, Dubois D, Coulie B, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clinical Gastroenterol Hepatol. 2005;3:543–52.

    Google Scholar 

  97. Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology 2009;136:376–86.

    PubMed  Google Scholar 

  98. Lacy BE, Weiser K, Chertoff J, et al. The diagnosis of gastroesophageal reflux disease. Am J Med. 2010;123:583–92.

    PubMed  Google Scholar 

  99. Prakash Gyawali C. Esophageal hypersensitivity. Gastroenterol Hepatol. 2010;6:497–500.

    CAS  Google Scholar 

  100. Zerbib F, Bruley des Varannes S, Simon M, Galmiche JP. Functional heartburn: definition and management strategies. Curr Gastroenterol Rep. 2012;14:181–8.

    PubMed  Google Scholar 

  101. Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J. Esophageal sensation and esophageal hypersensitivity—overview from bench to bedside. J Neurogastroenterol Motil. 2010;16:353–62.

    PubMed Central  PubMed  Google Scholar 

  102. Nasr I, Attaluri A, Hashmi S, Gregersen H, Rao SS. Investigation of esophageal sensation and biomechanical properties in functional chest pain. Neurogastroenterol Motil. 2010;22:520–6, e116.

    CAS  PubMed Central  PubMed  Google Scholar 

  103. McDonald-Haile J, Bradley LA, Bailey MA, Schan CA, Richter JE. Relaxation training reduces symptom reports and acid exposure in patients with gastroesophageal reflux disease. Gastroenterology. 1994;107:61–9.

    CAS  PubMed  Google Scholar 

  104. Naliboff BD, Mayer M, Fass R, et al. The effect of life stress on symptoms of heartburn. Psychosom Med. 2004;66:426–34.

    PubMed  Google Scholar 

  105. Yang M, Li ZS, Chen DF, et al. Quantitative assessment and characterization of visceral hyperalgesia evoked by esophageal balloon distention and acid perfusion in patients with functional heartburn, nonerosive reflux disease, and erosive esophagitis. Clin J Pain. 2010;26:326–31.

    CAS  PubMed  Google Scholar 

  106. Ke MY. How to differentiate non-erosive reflux disease from functional heartburn. J Dig Dis. 2012;13:605–8.

    PubMed  Google Scholar 

  107. Rao SS, Hayek B, Summers RW. Functional chest pain of esophageal origin: hyperalgesia or motor dysfunction. Am J Gastroenterol. 2001;96:2584–9.

    CAS  PubMed  Google Scholar 

  108. Quigley EM, Lacy BE. Overlap of functional dyspepsia and GERD-diagnostic and treatment implications. Nat Rev Gastroenterol Hepatol. 2013;10:175–86.

    CAS  PubMed  Google Scholar 

  109. Lee BE, Kim GH. Globus pharyngeus: a review of its etiology, diagnosis and treatment. World J Gastroenterol. 2012;18:2462–71.

    PubMed Central  PubMed  Google Scholar 

  110. Kiebles JL, Kwiatek MA, Pandolfino JE, Kahrilas PJ, Keefer L. Do patients with globus sensation respond to hypnotically assisted relaxation therapy? A case series report. Dis Esophagus. 2010;23:545–53.

    CAS  PubMed  Google Scholar 

  111. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006;130:1377–90.

    PubMed  Google Scholar 

  112. Naliboff BD, Frese MP, Rapgay L. Mind/body psychological treatments for irritable bowel syndrome. Evid Based Complement Alternat Med. 2008;5:41–50.

    PubMed Central  PubMed  Google Scholar 

  113. Zijdenbos IL, de Wit NJ, van der Heijden GJ, Rubin G, Quartero AO. Psychological treatments for the management of irritable bowel syndrome. Cochrane Database Syst Rev. 2009;CD006442.

    Google Scholar 

  114. Hislop IG. Effect of very brief psychotherapy on the irritable bowel syndrome. Med J Aust. 1980;2:620–3.

    CAS  PubMed  Google Scholar 

  115. Hyphantis T, Guthrie E, Tomenson B, Creed F. Psychodynamic interpersonal therapy and improvement in interpersonal difficulties in people with severe irritable bowel syndrome. Pain. 2009;145:196–203.

    PubMed  Google Scholar 

  116. Creed F, Guthrie E, Ratcliffe J, et al. Reported sexual abuse predicts impaired functioning but a good response to psychological treatments in patients with severe irritable bowel syndrome. Psychosom Med. 2005;67:490–9.

    PubMed  Google Scholar 

  117. Creed F, Fernandes L, Guthrie E, et al. The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome. Gastroenterology. 2003;124:303–17.

    PubMed  Google Scholar 

  118. Miller V, Whorwell PJ. Hypnotherapy for functional gastrointestinal disorders: a review. Int J Clin Exp Hypn. 2009;57:279–92.

    PubMed  Google Scholar 

  119. Jones H, Cooper P, Miller V, Brooks N, Whorwell PJ. Treatment of non-cardiac chest pain: a controlled trial of hypnotherapy. Gut. 2006;55:1403–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  120. Palsson OS, Whitehead WE. Hypnosis for non-cardiac chest pain. Gut. 2006;55:1381–4.

    CAS  PubMed Central  PubMed  Google Scholar 

  121. Calvert EL, Houghton LA, Cooper P, Morris J, Whorwell PJ. Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology. 2002;123:1778–85.

    PubMed  Google Scholar 

  122. Lindfors P, Ljotsson B, Bjornsson E, Abrahamsson H, Simren M. Patient satisfaction after gut-directed hypnotherapy in irritable bowel syndrome. Neurogastroenterol Motil. 2013;25:169–e86.

    CAS  PubMed  Google Scholar 

  123. Whorwell PJ. Effective management of irritable bowel syndrome-the Manchester model. Int J Clin Exp Hypn. 2006;54:21–6.

    PubMed  Google Scholar 

  124. Palsson OS. Standardized hypnosis treatment for irritable bowel syndrome: the North Carolina protocol. Int J Clin Exp Hypn. 2006;54:51–64.

    PubMed  Google Scholar 

  125. Lindfors P, Unge P, Nyhlin H, et al. Long-term effects of hypnotherapy in patients with refractory irritable bowel syndrome. Scand J Gastroenterol. 2012;47:414–20.

    PubMed  Google Scholar 

  126. Lindfors P, Unge P, Arvidsson P, et al. Effects of gut-directed hypnotherapy on IBS in different clinical settings-results from two randomized, controlled trials. Am J Gastroenterol. 2012;107:276–85.

    PubMed  Google Scholar 

  127. Gonsalkorale WM, Miller V, Afzal A, Whorwell PJ. Long term benefits of hypnotherapy for irritable bowel syndrome. Gut. 2003;52:1623–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  128. Blanchard EB, Schwarz SP, Radnitz CR. Psychological assessment and treatment of irritable bowel syndrome. Behav Modif. 1987;11:348–72.

    CAS  PubMed  Google Scholar 

  129. Payne A, Blanchard EB. A controlled comparison of cognitive therapy and self-help support groups in the treatment of irritable bowel syndrome. J Consult Clin Psychol. 1995;63:779–86.

    CAS  PubMed  Google Scholar 

  130. Greene B, Blanchard EB. Cognitive therapy for irritable bowel syndrome. J Consult Clin Psychol. 1994;62:576–82.

    CAS  PubMed  Google Scholar 

  131. Corney RH, Stanton R, Newell R, Clare A, Fairclough P. Behavioural psychotherapy in the treatment of irritable bowel syndrome. J Psychosom Res. 1991;35:461–9.

    CAS  PubMed  Google Scholar 

  132. Bennett P, Wilkinson S. A comparison of psychological and medical treatment of the irritable bowel syndrome. Br J Clin Psychol. 1985;24 (Pt 3):215–6.

    PubMed  Google Scholar 

  133. van Dulmen AM, Fennis JF, Bleijenberg G. Cognitive-behavioral group therapy for irritable bowel syndrome: effects and long-term follow-up. Psychosom Med. 1996;58:508–14.

    CAS  PubMed  Google Scholar 

  134. Blanchard EB, Lackner JM, Sanders K, et al. A controlled evaluation of group cognitive therapy in the treatment of irritable bowel syndrome. Behav Res Ther. 2007;45:633–48.

    PubMed  Google Scholar 

  135. Lackner JM, Gudleski GD, Keefer L, Krasner SS, Powell C, Katz LA. Rapid response to cognitive behavior therapy predicts treatment outcome in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2010;8:426–32.

    PubMed Central  PubMed  Google Scholar 

  136. Lackner JM, Keefer L, Jaccard J, et al. The Irritable Bowel Syndrome Outcome Study (IBSOS): rationale and design of a randomized, placebo-controlled trial with 12 month follow up of self-versus clinician-administered CBT for moderate to severe irritable bowel syndrome. Contemp Clin Trials. 2012;33:1293–310.

    PubMed Central  PubMed  Google Scholar 

  137. Jarrett ME, Cain KC, Burr RL, Hertig VL, Rosen SN, Heitkemper MM. Comprehensive self-management for irritable bowel syndrome: randomized trial of in-person vs. combined in-person and telephone sessions. Am J Gastroenterol. 2009;104:3004–14.

    PubMed Central  PubMed  Google Scholar 

  138. Hunt MG, Moshier S, Milonova M. Brief cognitive-behavioral internet therapy for irritable bowel syndrome. Behav Res Ther. 2009;47:797–802.

    PubMed  Google Scholar 

  139. Ljotsson B, Andersson G, Andersson E, et al. Acceptability, effectiveness, and cost-effectiveness of internet-based exposure treatment for irritable bowel syndrome in a clinical sample: a randomized controlled trial. BMC Gastroenterol. 2011;11:110.

    PubMed Central  PubMed  Google Scholar 

  140. Halpert A, Dalton CB, Palsson O, et al. Irritable bowel syndrome patients’ ideal expectations and recent experiences with healthcare providers: a national survey. Dig Dis Sci. 2010;55:375–83.

    PubMed  Google Scholar 

  141. Jones MP, Keefer L, Bratten J, et al. Development and initial validation of a measure of perceived stigma in irritable bowel syndrome. Psychol Health Med. 2009;14:367–74.

    PubMed  Google Scholar 

  142. Taft TH, Keefer L, Artz C, Bratten J, Jones MP. Perceptions of illness stigma in patients with inflammatory bowel disease and irritable bowel syndrome. Qual Life Res. 2011;20:1391–9.

    PubMed  Google Scholar 

  143. Dobbin A, Dobbin J, Ross SC, Graham C, Ford MJ. Randomised controlled trial of brief intervention with biofeedback and hypnotherapy in patients with refractory irritable bowel syndrome. J R Coll Physicians Edinb. 2013;43:15–23.

    CAS  PubMed  Google Scholar 

  144. Asare F, Storsrud S, Simren M. Meditation over medication for irritable bowel syndrome? On exercise and alternative treatments for irritable bowel syndrome. Curr Gastroenterol Rep. 2012;14:283–9.

    PubMed  Google Scholar 

  145. Keefer L, Blanchard EB. The effects of relaxation response meditation on the symptoms of irritable bowel syndrome: results of a controlled treatment study. Behav Res Ther. 2001;39:801–11.

    CAS  PubMed  Google Scholar 

  146. Hussain Z, Quigley EM. Systematic review: complementary and alternative medicine in the irritable bowel syndrome. Aliment Pharmacol Ther. 2006;23:465–71.

    CAS  PubMed  Google Scholar 

  147. Birtwhistle RV. Irritable bowel syndrome: are complementary and alternative medicine treatments useful? Can Fam Physician. 2009;55:126–7, 8–9.

    Google Scholar 

  148. Magge S, Lembo A. Complementary and alternative medicine for the irritable bowel syndrome. Gastroenterol Clin North Am. 2011;40:245–53.

    PubMed  Google Scholar 

  149. Dorn SD, Kaptchuk TJ, Park JB, et al. A meta-analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome. Neurogastroenterol Motil. 2007;19:630–7.

    CAS  PubMed  Google Scholar 

  150. Marri SR, Buchman AL. The education and employment status of patients with inflammatory bowel diseases. Inflamm Bowel Dis. 2005;11:171–7.

    PubMed  Google Scholar 

  151. Farrokhyar F, Swarbrick ET, Irvine EJ. A critical review of epidemiological studies in inflammatory bowel disease. Scand J Gastroenterol. 2001;36:2–15.

    CAS  PubMed  Google Scholar 

  152. Carter MJ, Jones S, Camp NJ, et al. Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis. Genes Immun. 2004;5:8–15.

    CAS  PubMed  Google Scholar 

  153. Kornbluth A, Sachar DB. Practice parameters committee of the American college of G. ulcerative colitis practice guidelines in adults (update): American college of gastroenterology, practice parameters committee. Am J Gastroenterol. 2004;99:1371–85.

    PubMed  Google Scholar 

  154. Irvine EJ. Quality of life issues in patients with inflammatory bowel disease. Am J Gastroenterol. 1997;92:18S–24S.

    CAS  PubMed  Google Scholar 

  155. Goodhand J, Rampton D. Psychological stress and coping in IBD. Gut. 2008;57:1345–7.

    PubMed  Google Scholar 

  156. Mawdsley JE, Rampton DS. Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut. 2005;54:1481–91.

    CAS  PubMed Central  PubMed  Google Scholar 

  157. Triantafillidis JK, Merikas E, Gikas A. Psychological factors and stress in inflammatory bowel disease. Expert Rev Gastroenterol Hepatol. 2013;7:225–38.

    CAS  PubMed  Google Scholar 

  158. Frolkis A, Dieleman LA, Barkema H, et al. Environment and the inflammatory bowel diseases. Can J Gastroenterol. 2013;27:e18–24.

    PubMed Central  PubMed  Google Scholar 

  159. Ananthakrishnan AN, Long MD, Martin CF, Sandler RS, Kappelman MD. Sleep disturbance and risk of active disease in patients with Crohn’s disease and ulcerative colitis. Clinical Gastroenterol Hepatol 2013;11(8):965–71.

    Google Scholar 

  160. Loftus EV, Jr., Schoenfeld P, Sandborn WJ. The epidemiology and natural history of Crohn’s disease in population-based patient cohorts from North America: a systematic review. Aliment Pharmacol Ther. 2002;16:51–60.

    PubMed  Google Scholar 

  161. Sandborn WJ, Feagan BG, Lichtenstein GR. Medical management of mild to moderate Crohn’s disease: evidence-based treatment algorithms for induction and maintenance of remission. Aliment Pharmacol Ther. 2007;26:987–1003.

    CAS  PubMed  Google Scholar 

  162. Miehsler W, Weichselberger M, Offerlbauer-Ernst A, et al. Which patients with IBD need psychological interventions? A controlled study. Inflamm Bowel Dis. 2008;14:1273–80.

    PubMed  Google Scholar 

  163. Drossman DA, Leserman J, Mitchell CM, Li ZM, Zagami EA, Patrick DL. Health status and health care use in persons with inflammatory bowel disease. A national sample. Dig Dis Sci. 1991;36:1746–55.

    CAS  PubMed  Google Scholar 

  164. Rubin DT, Dubinsky MC, Panaccione R, et al. The impact of ulcerative colitis on patients’ lives compared to other chronic diseases: a patient survey. Dig Dis Sci. 2010;55:1044–52.

    PubMed  Google Scholar 

  165. Benevento G, Avellini C, Terrosu G, Geraci M, Lodolo I, Sorrentino D. Diagnosis and assessment of Crohn’s disease: the present and the future. Expert Rev Gastroenterol Hepatol. 2010;4:757–66.

    PubMed  Google Scholar 

  166. Albert JG, Kotsch J, Kostler W, et al. Course of Crohn’s disease prior to establishment of the diagnosis. Z Gastroenterol. 2008;46:187–92.

    CAS  PubMed  Google Scholar 

  167. Burgmann T, Clara I, Graff L, et al. The Manitoba inflammatory bowel disease Cohort study: prolonged symptoms before diagnosis—how much is irritable bowel syndrome? Clin Gastroenterol Hepatol. 2006;4:614–20.

    PubMed  Google Scholar 

  168. Kane S, Huo D, Aikens J, Hanauer S. Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am J Med. 2003;114:39–43.

    PubMed  Google Scholar 

  169. Sandborn WJ. Clinical perspectives in Crohn’s disease. Moving forward with anti-TNF-alpha therapy: current needs and future treatments. Rev Gastroenterol Disord. 2007;7(Suppl 2):S23–35.

    PubMed  Google Scholar 

  170. Hanauer SB. New steroids for IBD: progress report. Gut. 2002;51:182–3.

    CAS  PubMed Central  PubMed  Google Scholar 

  171. Keyashian K, Annunziata ML, Sakuraba A, Hanauer S. Management of inflammatory bowel disease: past, present and future. Expert Rev Clin Immunol. 2012;8:303–5.

    CAS  PubMed  Google Scholar 

  172. Campbell IA. Aggressive psychosis in AIDS patient on high-dose steroids. Lancet. 1987;2:750–1.

    CAS  PubMed  Google Scholar 

  173. Costantino G, Furfaro F, Belvedere A, Alibrandi A, Fries W. Thiopurine treatment in inflammatory bowel disease: response predictors, safety, and withdrawal in follow-up. J Crohns Colitis. 2012;6:588–96.

    PubMed  Google Scholar 

  174. Siegel CA, Levy LC, Mackenzie TA, Sands BE. Patient perceptions of the risks and benefits of infliximab for the treatment of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14:1–6.

    PubMed  Google Scholar 

  175. Bitton A, Peppercorn MA, Antonioli DA, et al. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology. 2001;120:13–20.

    CAS  PubMed  Google Scholar 

  176. Taft TH, Keefer L, Leonhard C, Nealon-Woods M. Impact of perceived stigma on inflammatory bowel disease patient outcomes. Inflamm Bowel Dis. 2009;15:1224–32.

    PubMed Central  PubMed  Google Scholar 

  177. Moser G. [Depression and anxiety in inflammatory bowel disease]. Gastroenterol Hepatol. 2009;32 Suppl 2:9–12.

    PubMed  Google Scholar 

  178. Lix LM, Graff LA, Walker JR, et al. Longitudinal study of quality of life and psychological functioning for active, fluctuating, and inactive disease patterns in inflammatory bowel disease. Inflamm Bowel Dis. 2008;14:1575–84.

    PubMed  Google Scholar 

  179. Mikocka-Walus AA, Turnbull DA, Andrews JM, Moulding NT, Holtmann GJ. The effect of functional gastrointestinal disorders on psychological comorbidity and quality of life in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2008;28:475–83.

    CAS  PubMed  Google Scholar 

  180. Stjernman H, Tysk C, Almer S, Strom M, Hjortswang H. Worries and concerns in a large unselected cohort of patients with Crohn’s disease. Scand J Gastroenterol. 2010;45:696–706.

    PubMed  Google Scholar 

  181. Baars JE, Siegel CA, Kuipers EJ, van der Woude CJ. Patient’s perspectives important for early anti-tumor necrosis factor treatment in inflammatory bowel disease. Digestion. 2009;79:30–5.

    CAS  PubMed Central  PubMed  Google Scholar 

  182. Saha S, Wald A. Safety and efficacy of immunomodulators and biologics during pregnancy and lactation for the treatment of inflammatory bowel disease. Expert Opin Drug Saf. 2012;11:947–57.

    CAS  PubMed Central  PubMed  Google Scholar 

  183. Kiebles JL, Doerfler B, Keefer L. Preliminary evidence supporting a framework of psychological adjustment to inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:1685–95.

    PubMed Central  PubMed  Google Scholar 

  184. Kane SV, Robinson A. Review article: understanding adherence to medication in ulcerative colitis—innovative thinking and evolving concepts. Aliment Pharmacol Ther. 2010;32:1051–8.

    CAS  PubMed  Google Scholar 

  185. Kane S. Medication adherence and the physician-patient relationship. Am J Gastroenterol. 2002;97:1853.

    PubMed  Google Scholar 

  186. McCombie AM, Mulder RT, Gearry RB. Psychotherapy for inflammatory bowel disease: a review and update. J Crohns Colitis. 2013;7(12):935–49.

    Google Scholar 

  187. Keefer L, Kiebles JL, Martinovich Z, Cohen E, Van Denburg A, Barrett TA. Behavioral interventions may prolong remission in patients with inflammatory bowel disease. Behav Res Ther 2011;49:145–50.

    PubMed Central  PubMed  Google Scholar 

  188. Rakshit RC, Mayberry JF. What is the role of patient education in the care of IBD? Inflamm Bowel Dis. 2008;14(Suppl 2):S66–7.

    PubMed  Google Scholar 

  189. Keefer L, Kiebles JL, Kwiatek MA, et al. The potential role of a self-management intervention for ulcerative colitis: a brief report from the ulcerative colitis hypnotherapy trial. Biol Res Nurs. 2012;14:71–7.

    PubMed Central  PubMed  Google Scholar 

  190. Kahrilas PJ. GERD pathogenesis, pathophysiology, and clinical manifestations. Cleve Clin J Med. 2003;70 Suppl 5:S4–19.

    PubMed  Google Scholar 

  191. Kahrilas PJ. Clinical practice. Gastroesophageal reflux disease. N Engl J Med. 2008;359:1700–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  192. Fass R. Erosive esophagitis and nonerosive reflux disease (NERD): comparison of epidemiologic, physiologic, and therapeutic characteristics. J Clini Gastroenterol. 2007;41:131–7.

    Google Scholar 

  193. Long JD, Orlando RC. Nonerosive reflux disease. Minerva Gastroenterol Dietol. 2007;53:127–41.

    CAS  PubMed  Google Scholar 

  194. Jonasson C, Wernersson B, Hoff DA, Hatlebakk JG. Validation of the GerdQ questionnaire for the diagnosis of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2013;37:564–72.

    CAS  PubMed  Google Scholar 

  195. Richter JE. Gastroesophageal reflux disease and obesity: not as simple as we may think. Dig Dis Sci. 2012;57:1748–50.

    PubMed  Google Scholar 

  196. Fass R. Therapeutic options for refractory gastroesophageal reflux disease. J Gastroenterol Hepatol. 2012;27 Suppl 3:3–7.

    CAS  PubMed  Google Scholar 

  197. Heidelbaugh JJ, Metz DC, Yang YX. Proton pump inhibitors: are they overutilised in clinical practice and do they pose significant risk? Int J Clin Pract. 2012;66:582–91.

    CAS  PubMed  Google Scholar 

  198. Miwa H, Takubo K, Shimatani T, et al. Histology of symptomatic gastroesophageal reflux disease: is it predictive of response to proton pump inhibitors? J Gastroenterol Hepatol. 2013;28:479–87.

    CAS  PubMed  Google Scholar 

  199. Aslam N, Wright R. Dexlansoprazole MR. Expert Opin Pharmacother. 2009;10:2329–36.

    CAS  PubMed  Google Scholar 

  200. Falk GW, Jacobson BC, Riddell RH, et al. Barrett’s esophagus: prevalence-incidence and etiology-origins. Ann N Y Acad Sci 2011;1232:1–17.

    CAS  PubMed  Google Scholar 

  201. Katada N, Sakuramoto S, Yamashita K, et al. Recent trends in the management of achalasia. Ann Thorac Cardiovasc Surg. 2012;18:420–8.

    PubMed  Google Scholar 

  202. Tutuian R, Castell DO. Esophageal motility disorders (distal esophageal spasm, nutcracker esophagus, and hypertensive lower esophageal sphincter): modern management. Current Treat Options Gastroenterol. 2006;9:283–94.

    Google Scholar 

  203. Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133:1342–63.

    CAS  PubMed  Google Scholar 

  204. Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128:3–20.e6; quiz 1–2.

    PubMed  Google Scholar 

  205. Taft TH, Kern E, Kwiatek MA, Hirano I, Gonsalves N, Keefer L. The adult eosinophilic oesophagitis quality of life questionnaire: a new measure of health-related quality of life. Aliment Pharmacol Therap. 2011;34:790–8.

    CAS  Google Scholar 

  206. Taft TH, Kern E, Keefer L, Burstein D, Hirano I. Qualitative assessment of patient-reported outcomes in adults with eosinophilic esophagitis. J Clin Gastroenterol. 2011;45:769–74.

    PubMed  Google Scholar 

  207. Richter, J. Functional Heartburn. International Foundation for Functional Gastrointestinal Disorders. Milwaukee: 2006.

    Google Scholar 

  208. Jones MP1, Keefer L, Bratten J, Taft TH, Crowell MD, Levy R, Palsson O. Development and initial validation of a measure of perceived stigma in irritable bowel syndrome. Psychol Health Med. 2009 May;14(3):367–74. doi: 10.1080/13548500902865956.

    Google Scholar 

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Taft, T., Riehl, M. (2014). Gastrointestinal Conditions. In: Hunter, C., Hunter, C., Kessler, R. (eds) Handbook of Clinical Psychology in Medical Settings. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09817-3_18

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