The Role of the Leydig Cell in Spermatogenic Function

  • Renshan Ge
  • Guorong Chen
  • Matthew P. HardyEmail author
Part of the Advances in Experimental Medicine and Biology book series (volume 636)


Two anatomically distinct compartments, respectively, the interstitium where Leydig cells reside and the seminiferous tubules contribute the major functions of the testis, testosterone secretion and sperm production. This structural partitioning is achieved by peritubular myoid cells, which surround the seminiferous tubules. Despite the anatomic separation of the two compartments, they are functionally coupled by endocrine and paracrine inter-communication. For example, the testosterone secreted by Leydig cells under the stimulus of luteinizing hormone (LH), diffuses into seminiferous tubules and drives spermatogenesis together with another gonadotropic hormone, follicle-stimulating hormone (FSH). This dependency of the seminiferous epithelium on testosterone illustrates the significance of the Leydig cell in spermatogenesis.


Androgen Receptor Sertoli Cell Leydig Cell Seminiferous Tubule Androgen Receptor Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.The Population Council and The Rockefeller UniversityNew YorkUSA

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