Abstract
Coronins have maintained a high degree of conservation over the roughly 800 million years of eukaryotic evolution.1,2 From its origins as a single gene in simpler eukaryotes, the mammalian Coronin gene family has expanded to include at least six members (see Chapter 4). Increasing evidence indicates that Coronins play critical roles as regulators of actin dependent processes such as cell motility and vesicle trafficking3,4 (see Chapters 6–9). Considering the importance of these processes, it is not surprising that recent findings have implicated the involvement of Coronins in multiple diseases. This review primarily focuses on Coronin 1C (HGNC symbol: CORO1C, also known as Coronin 3) which is a transcriptionally dynamic gene that is up-regulated in multiple types of clinically aggressive cancer. In addition to reviewing the molecular signals and events that lead to Coronin 1C transcription, we summarize the results of several studies describing the possible functional roles of Coronin 1C in development as well as disease progression. Here, the main focus is on brain development and on the progression of melanoma and glioma. Finally, we will also review the role of other mammalian Coronin genes in clinically relevant processes such as neural regeneration and pathogenic bacterial infections (see Chapter 10).
These authors contributed equally to this work.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Rybakin V, Clemen CS. Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking. Bioessays 2005; 27(6):625–632.
Uetrecht AC, Bear JE. Coronins: the return of the crown. Trends Cell Biol 2006; 16(8): 421–426.
Cai L, Marshall TW, Uetrecht AC et al. Coronin 1B coordinates Arp 2/3 complex and cofilin activities at the leading edge. Cell 2007; 128(5):915–929.
Rosentreter A, Hofmann A, Xavier CP et al. Coronin 3 involvement in F-actin-dependent processes at the cell cortex. Exp Cell Res 2007; 313(5):878–895.
Wick M, Burger C, Brusselbach S et al. Identification of serum-inducible genes: different patterns of gene regulation during G0→S and G1→S progression. J Cell Sci 1994; 107 (Pt 1):227–239.
Chang HY, Sneddon JB, Alizadeh AA et al. Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds. PloS Biol 2004; 2(2):E7.
Tullai JW, Schaffer ME, Mullenbrock S et al. Immediate-early and delayed primary response genes are distinct in function and genomic architecture. J Biol Chem 2007; 282(33):23981–95
Li Z, Van Calcar S, Qu C et al. A global transcriptional regulatory role for c-Myc in Burkitt’s lymphoma cells. Proc Natl Acad Sci USA 2003; 100(14):8164–8169.
Moreno-Bueno G, Cubillo E, Sarrio D et al. Genetic profiling of epithelial cells expressing e-cadherin repressors reveals a distinct role for snail, slug and e47 factors in epithelial-mesenchymal transition. Cancer Res 2006; 66(19):9543–9556.
Moreno-Bueno G, Sanchez-Estevez C, Cassia R et al. Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas. Cancer Res 2003; 63(18):5697–5702.
Winter SC, Buffa FM, Silva P et al. Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers. Cancer Res 2007; 67(7):3441–3449.
Nordsmark M, Bentzen SM, Rudat V et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005; 77(1):18–24.
Zhao H, Kim Y, Wang P et al. Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines. Prostate 2005; 63(2):187–197.
Bonaccorsi L, Muratori M, Carloni V et al. Androgen receptor and prostate cancer invasion. Int J Androl 2003; 26(1):21–25.
Sharpless NE, Chin L. The INK4a/ARF locus and melanoma. Oncogene 2003; 22(20):3092–3098.
Chin L, Merlino G, DePinho RA. Malignant melanoma: modern black plague and genetic black box. Genes Dev 1998; 12(22):3467–3481.
Cochran AJ. Prediction of outcome for patients with cutaneous melanoma. Pigment Cell Res 1997; 10(3):162–167.
Ahmed I. Malignant melanoma: prognostic indicators. Mayo Clin Proc 1997; 72(4):356–361.
Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417(6892):949–954.
Omholt K, Karsberg S, Platz A et al. Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression. Clin Cancer Res 2002; 8(11):3468–3474.
Herlyn M, Satyamoorthy K. Activated ras. Yet another player in melanoma? Am J Pathol 1996; 149(3):739–744.
Schulze A, Nicke B, Warne PH et al. The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component. Mol Biol Cell 2004; 15(7):3450–3463.
Shields JM, Thomas NE, Cregger M et al. Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Res 2007; 67(4):1502–1512.
Clark EA, Golub TR, Lander ES et al. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000; 406(6795):532–535.
Wang W, Wyckoff JB, Goswami S et al. Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer Res 2007; 67(8):3505–3511.
Bear JE, Roadcap DW. Unpublished Data. 2007.
Hasse A, Rosentreter A, Spoerl Z et al. Coronin 3 and its role in murine brain morphogenesis. Eur J Neurosci 2005; 21(5):1155–1168.
Berry M. Development of the cerebral neocortex of the rat. In: Gottlieb G, ed. Aspects of Neurogenesis. New York: Academic Press, 1974: Vol. 2. pp. 7–67.
Massey PV, Bashir ZI. Long-term depression: multiple forms and implications for brain function. Trends Neurosci 2007; 30(4):176–184.
Matsuzaki M, Honkura N, Ellis-Davies GC et al. Structural basis of long-term potentiation in single dendritic spines. Nature 2004; 429(6993):761–766.
Krucker T, Siggins GR, Halpain S. Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. Proc Natl Acad Sci USA 2000; 97(12):6856–6861.
Fukazawa Y, Saitoh Y, Ozawa F et al. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 2003; 38(3):447–460.
Bjartmar C, Hildebrand C, Loinder K. Morphological heterogeneity of rat oligodendrocytes: Electron microscopic studies on serial sections. Glia 1994; 11:235–244.
Coffrey JC, McDermott KW. The regional distribution of myelin oligodendrocyte glycoprotein (MOG) in the developing rat CNS: An in vivo immunohistochemical study. J Neurocytol 1997; 26:149–161.
Weitzdoerfer R, Fountoulakis M, Lubec G. Reduction of actin-related protein complex 2/3 in fetal Down syndrome brain. Biochem Biophys Res Commun 2002; 293(2):836–841.
Neer EJ, Schmidt CJ, Smith T. LIS is more. Nat Genet 1993; 5(1):3–4.
Lo Nigro C, Chong CS, Smith AC et al. Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome. Hum Mol Genet 1997; 6(2):157–164.
Henning KA, Li L, Iyer N et al. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Cell 1995; 82(4):555–564.
Bassi MT, Ramesar RS, Caciotti B et al. X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. Am J Hum Genet 1999; 64(6):1604–1616.
Tullio-Pelet A, Salomon R, Hadj-Rabia S et al. Mutant WD-repeat protein in triple-A syndrome. Nat Genet 2000; 26(3):332–335.
Handschug K, Sperling S, Yoon SJ et al. Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene. Hum Mol Genet 2001; 10(3):283–290.
Spoerl Z, Stumpf M, Noegel AA et al. Oligomerization, F-actin interaction and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. J Biol Chem 2002; 277(50):48858–48867.
Thal DR, Xavier CP, Rosentreter A et al. Expression of coronin 3 in diffuse gliomas is related to malignancy. J Pathol. In press.
Kleihues P, Cavenee WK. Pathology and Genetics: Tumours of the Nervous System. Lyon: IARC-Press; 2000.
Foger N, Rangell L, Danilenko DM et al. Requirement for coronin 1 in T-lymphocyte trafficking and cellular homeostasis. Science 2006; 313(5788):839–842.
Yanagisawa Y, Sato Y, Asahi-Ozaki Y et al. Effusion and solid lymphomas have distinctive gene and protein expression profiles in an animal model of primary effusion lymphoma. J Pathol 2006; 209(4):464–473.
Graham SM, Vass JK, Holyoake TL et al. Transcriptional analysis of quiescent and proliferating CD34+ human haemopoietic cells from normal and CML sources. Stem Cells 2007; 25(12):3111–20.
Wilson CS, Davidson GS, Martin SB et al. Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood 2006; 108(2):685–696.
Sasaki H, Nishikata I, Shiraga T et al. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood 2005; 105(3):1204–1213.
Mahadevan D, Spier C, Della Croce K et al. Transcript profiling in peripheral T-cell lymphoma, not otherwise specified and diffuse large B-cell lymphoma identifies distinct tumor profile signatures. Mol Cancer Ther 2005; 4(12):1867–1879.
Ferrari G, Langen H, Naito M et al. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell 1999; 97(4):435–447.
Vergne I, Chua J, Singh SB et al. Cell biology of mycobacterium tuberculosis phagosome. Annu Rev Cell Dev Biol 2004; 20:367–394.
Anes E, Kuhnel MP, Bos E et al. Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria. Nat Cell Biol 2003; 5(9):793–802.
Deghmane AE, Soulhine H, Bach H et al. Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. J Cell Sci 2007; 120(16):2796–806.
Jayachandran R, Sundaramurthy V, Combaluzier B et al. Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell 2007; 130(1):37–50.
Parekh AB, Putney JW Jr. Store-operated calcium channels. Physiol Rev 2005; 85(2):757–810.
Gallo EM, Cante-Barrett K, Crabtree GR. Lymphocyte calcium signaling from membrane to nucleus. Nat Immunol 2006; 7(1):25–32.
Cai L, Holoweckyj N, Schaller MD et al. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. J Biol Chem 2005; 280(36):31913–31923.
Di Giovanni S, De Biase A, Yakovlev A et al. In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury. J Biol Chem 2005; 280(3):2084–2091.
Di Giovanni S, Knights CD, Rao M et al. The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. EMBO J 2006; 25(17):4084–4096.
Martinez I, Lombardia L, Garcia-Barreno B et al. Distinct gene subsets are induced at different time points after human respiratory syncytial virus infection of A549 cells. J Gen Virol 2007; 88(Pt 2):570–581.
Fujimura N, Vacik T, Machon O et al. Wnt-mediated down-regulation of SP1 target genes by a transcriptional repressor Sp5. J Biol Chem 2007; 282(2):1225–1237.
Hartman ZC, Kiang A, Everett RS et al. Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. J Virol 2007; 81(4):1796–1812.
Pellagatti A, Cazzola M, Giagounidis AA et al. Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype. Blood 2006; 108(1):337–345.
Kakiuchi S, Daigo Y, Ishikawa N et al. Prediction of sensitivity of advanced nonsmall cell lung cancers to gefitinib (Iressa, ZD1839). Hum Mol Genet 2004; 13(24):3029–3043.
Hertel L, Mocarski ES. Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function. J Virol 2004; 78(21):11988–12011.
Ning W, Li CJ, Kaminski N et al. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci USA 2004; 101(41):14895–14900.
Chen H, Huang XN, Stewart AF et al. Gene expression changes associated with fibronectin-induced cardiac myocyte hypertrophy. Physiol Genomics 2004; 18(3):273–283.
Messmer D, Messmer B, Chiorazzi N. The global transcriptional maturation program and stimuli-specific gene expression profiles of human myeloid dendritic cells. Int Immunol 2003; 15(4):491–503.
Ross ME, Zhou X, Song G et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 2003; 102(8):2951–2959.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Landes Bioscience and Springer Science+Business Media
About this chapter
Cite this chapter
Roadcap, D.W., Clemen, C.S., Bear, J.E. (2008). The Role of Mammalian Coronins in Development and Disease. In: Clemen, C.S., Eichinger, L., Rybakin, V. (eds) The Coronin Family of Proteins. Subcellular Biochemistry, vol 48. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09595-0_12
Download citation
DOI: https://doi.org/10.1007/978-0-387-09595-0_12
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-09594-3
Online ISBN: 978-0-387-09595-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)