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Retroviruses and Insights into Cancer pp 53–94Cite as

Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses

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Abstract

The proliferation and differentiation of cells is a highly regulated process that is controlled primarily at the level of the interaction of growth factors with their cell surface receptors. However, a variety of different retroviruses alter signal transduction pathways in infected cells, which is critical for the pathogenic process. Many studies have focused on how viral oncogenes and pathogenic genes associated with these retroviruses deregulate signal transduction pathways. Protein kinases, either encoded or activated by retroviruses, appear to play a major role. In this chapter, the effects of oncogenic retroviruses on signal transduction pathways will be reviewed for four oncogenic retroviruses: Abelson murine leukemia virus, S13 avian erythroblastosis virus, Friend spleen focus-forming virus, and Jaagsiekte sheep retrovirus. Each retrovirus uses a different mechanism to deregulate cell signaling.

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  1. Laboratory of Cancer Prevention, National Cancer Institute-Frederick, Building 567, Room 152, Frederick, Maryland, 21702-1201, USA

    Sandra K. Ruscetti

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  2. Joan L. Cmarik
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    Jaquelin Dudley

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Ruscetti, S.K., Cmarik, J.L. (2010). Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses. In: Dudley, J. (eds) Retroviruses and Insights into Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09581-3_3

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