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Thioredoxin Signaling in the Ischemic Heart

  • Chapter
Signal Transduction in the Cardiovascular System in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 3))

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Abstract

Thioredoxins are a class of small redox-regulating proteins that play a crucial role against various oxidative stress-inducible degenerative diseases. A recent study demonstrated that in the ischemic reperfused myocardium, thioredoxin-1 (Trx-1) level is reduced. Upon adaptation to ischemic stress by preconditioning with repeated cyclic episodes of small duration of ischemia and reperfusion, there was an increased expression of Trx-1. Inhibition of Trx-1 expression resulted in reduced postischemic ventricular recovery and increased myocardial infarct size in the preconditioned heart. Corroborating these findings, transgenic mouse hearts overexpressing Trx-1 were resistant to ischemic reperfusion injury as compared to the hearts from wild-type mice. Thus, it appears that thioredoxin plays a crucial role in cardioprotection induced by preconditioning.

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Authors and Affiliations

  1. Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT, USA

    Dipak K. Das

  2. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Shyamal K. Goswami

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  1. Dipak K. Das
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  2. Shyamal K. Goswami
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  1. Department of Medicine, University of Montreal and Research Centre of the Centre Hospitalier de l’ Universite de Montreal, Montreal, PQ, H1W 4A4, Canada

    Ashok K. Srivastava

  2. Department of Physiology Faculty of Medicine, University of Montreal, Montreal, PQ, H3C3J7, Canada

    Madhu B. Anand-Srivastava

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Das, D.K., Goswami, S.K. (2008). Thioredoxin Signaling in the Ischemic Heart. In: Srivastava, A.K., Anand-Srivastava, M.B. (eds) Signal Transduction in the Cardiovascular System in Health and Disease. Advances in Biochemistry in Health and Disease, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09552-3_7

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