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Angiotensin II Signaling: Cell Growth and Apoptosis

  • Chapter
Signal Transduction in the Cardiovascular System in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 3))

Abstract

Angiotensin II mediates both growth and death pathways in the young developing heart and the failing heart. Although stimulation of both processes by the same agent might seem counterproductive, the cell is capable of specifically regulating the process that will dominate. The secret behind the specificity of the response lies in the characteristics of the plethora of signaling pathways initiated by angiotensin II. It is generally felt that alterations in these pathways play a pivotal role in both the normal development of the young heart and the onset of pathology in the failing heart. Although the recent introduction of transgenic animals has proven valuable in assessing the contribution of specific pathways in the regulation of growth and apoptosis, more information is required on the interplay between these pathways and mediators of growth and apoptosis.

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  1. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA

    Stephen W. Schaffer

  2. Department of Oral Biology/Maxillofacial Pathology, Medical College of Georgia, Augusta, GA, USA

    Mahmood S. Mozaffari

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  1. Stephen W. Schaffer
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  2. Mahmood S. Mozaffari
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Editors and Affiliations

  1. Department of Medicine, University of Montreal and Research Centre of the Centre Hospitalier de l’ Universite de Montreal, Montreal, PQ, H1W 4A4, Canada

    Ashok K. Srivastava

  2. Department of Physiology Faculty of Medicine, University of Montreal, Montreal, PQ, H3C3J7, Canada

    Madhu B. Anand-Srivastava

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© 2008 Springer Science+Business Media, LLC

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Schaffer, S.W., Mozaffari, M.S. (2008). Angiotensin II Signaling: Cell Growth and Apoptosis. In: Srivastava, A.K., Anand-Srivastava, M.B. (eds) Signal Transduction in the Cardiovascular System in Health and Disease. Advances in Biochemistry in Health and Disease, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09552-3_6

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