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Signal Transduction in the Cardiovascular System in Health and Disease pp 267–284Cite as

The Signaling Duel Between Virus and Host: Impact on Coxsackieviral Pathogenesis

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 3))

Abstract

Coxsackievirus B3 (CVB3) is the primary human pathogen of viral myocarditis, a disease which causes sudden, unexpected death of infants and youth. Myocarditis was originally considered predominantly an inflammatory disease, but subsequent studies have revealed that direct myocardial injury by CVB3 prior to host immune responses contributes significantly to the progression of myocarditis. Heart transplantation is the only definitive treatment for serious myocarditis; thus, development of therapeutic intervention based on the pathogenesis of CVB3 becomes a preferred approach. Studies by our laboratory and others have shown that CVB3 infection triggers apoptosis of host cells through cytochrome C release and activation of multiple caspases. Furthermore, CVB3 infection activates several intracellular signaling pathways, such as the ERK pathway, the p38 MAPK pathway, and the PI3K/Akt pathway, for its efficient replication and release of progeny virions in order to complete its life cycle. Major cellular protein degradation systems, such as the ubiquitin–proteasome system, are also exploited by CVB3. These findings on the critical roles of host factors in pathogenesis of CVB3 thus provide us cellular targets for development of possible therapeutic interventions at molecular levels to restrain CVB3 infection.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia-St. Paul’s Hospital, Vancouver, BC, Canada

    Xiaoning Si, David Marchant, Decheng Yang, Bruce M. McManus & Honglin Luo

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  1. Xiaoning Si
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  2. David Marchant
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  3. Decheng Yang
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  4. Bruce M. McManus
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  5. Honglin Luo
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Editors and Affiliations

  1. Department of Medicine, University of Montreal and Research Centre of the Centre Hospitalier de l’ Universite de Montreal, Montreal, PQ, H1W 4A4, Canada

    Ashok K. Srivastava

  2. Department of Physiology Faculty of Medicine, University of Montreal, Montreal, PQ, H3C3J7, Canada

    Madhu B. Anand-Srivastava

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Si, X., Marchant, D., Yang, D., McManus, B.M., Luo, H. (2008). The Signaling Duel Between Virus and Host: Impact on Coxsackieviral Pathogenesis. In: Srivastava, A.K., Anand-Srivastava, M.B. (eds) Signal Transduction in the Cardiovascular System in Health and Disease. Advances in Biochemistry in Health and Disease, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09552-3_14

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