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Drug delivery to Brain by Microparticulate Systems

  • Conference paper
Biomaterials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 553))

Abstract

The site specific delivery of chemotherapeutic agents allows maximum concentration of an agent at a desired body site. This area specific drug delivery decreases the unwanted systemic distribution and decreases toxicity of the administered drugs.

retired — 2001

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References

  1. Brightman, M.W., 1997, Morphology of blood-brain interface. Exp. Eye Res. 25:1–25.

    Article  Google Scholar 

  2. Partridge, W.M., 1996, Brain drug delivery and blood-brain barrier transport. Drug Delivery 3: 99–115.

    Article  Google Scholar 

  3. Partridge, W.M., 1999, Vector mediated drug delivery to the brain. Adv. Del. Reviews 36: 299–321

    Article  Google Scholar 

  4. Kubo, O., Tajika, Y., Muragaki, Y., 1994, Local chemotherapy with slow releasing anticancer drug-polymers for malignant brain tumors. J. Cont. Rel. 32: 1–8.

    Article  Google Scholar 

  5. Menei, P, Boisdron-Celle, M, Croue, A., 1996, Effect of stereotaxic implantation of biodegradable 5-fluorouracil-loaded microspheres in healthy and C6 glioma-bearing rats. Neurusurgery 39: 117–124.

    Article  Google Scholar 

  6. Chandy, T., Das, G.S., Rao, G.H.R., 2000, 5-Fluorouracil loaded polylactic acid microspheres as biodegradable drug carrier for cerebral tumors, J. Microencapsulation 17: 625–638.

    Article  Google Scholar 

  7. Menei, P., Venier-Julienne, M.C., Benoit, J.P., 1997, Drug delivery into the brain using implantable polymeric systems. S. T.P. Pharma Sci. 7: 53–61.

    Google Scholar 

  8. Painbeni, T., Venier- Julienne, M.C., Benoit, J.P., 1998, Internal morphology of poly (D,L-lactide-co-glycolide) BCNU-loaded microspheres: Influence on drug stabiliy. Eur. J Pharm. Biopharm. 45: 31–39.

    Article  Google Scholar 

  9. Valtonen, S., Timonen, U., Tolvanen, P., 1997, Interstitial chemotherapy with carmustin loaded polymers for high grade gliomas: A randomized double-blind study. Neurosurgery 41: 44–48.

    Article  Google Scholar 

  10. Langer, R., 1990, New methods of drug delivery. Science 249: 1527–1533.

    Article  Google Scholar 

  11. Hassan, E.E. and Gallo, J.M., 1993, Targeting anticancer to the brain. 1. Enhanced brain delivery of oxantrazole following administration in magnetic cationic microspheres. J Drug Targeting1: 7–14.

    Article  Google Scholar 

  12. Kreuter, J., 1998, Recent advances in nanoparticles and nanospheres. In Biomedical Science and Technology (A.A. Hincal and H.S. Kas, eds.) Plenum Press, NY, pp. 31–39.

    Chapter  Google Scholar 

  13. Brigger, L., Morizet, J., Aubert, G., Chacun, H., Terrier-Lacombe, M.J., Couvreur, P., Vassal, G., 2002, Poly (ethylene glycol) coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting. J Pharm. Exp. Therapeutics 303: 928–936.

    Article  Google Scholar 

  14. Zhou, R., Mazurchuk, R., Straubinger, R.M., 2002, Antivasculature effects of doxorubicin containing liposomes in an intracranial rat brain tumor model. Cancer Res. 62: 2561–2566.

    Google Scholar 

  15. Koukourakis, M. I., 2002, 99mTc labeled stealth liposomal doxorubicin (CaelyxR) in glioblastomas and metastatic brain tumors. British J Cancer 86: 660–661.

    Article  Google Scholar 

  16. Chen, W. and Lu, D.R., 1999, Carboplatin loaded PLGA microspheres for intracerebral injection: formulation and characterisation. J Microencapsulation 16: 551–563.

    Article  Google Scholar 

  17. Whateley, T.L., Fallon, P.A., Robertson, L., 1995, In vivo study of PLGA implants for sustained delivery of carboplatin and etoposide to the brain. Proceed. Intern. Symp. Contol. Rel. Bioact. Mater. 22: 582–583.

    Google Scholar 

  18. Arica, B., Kas, H.S., Orman, M.N., Hincal, A.A., 2002, Biodegradable bromocryptine mesylate microspheres prepared by a solvent evaporation technique I. Evaluation of formulation variables on microsphere characteristics for brain delivery. J Microencapsulation 19: 473–484.

    Article  Google Scholar 

  19. Arica, B., Kas, H.S., Sargon, M.F., Acikgoz, B., Hincal, A.A., 1999, Biodegradable bromocryptine mesylate microspheres prepared by a solvent evaporation technique II. Suitability for brain and hypophysis delivery. S. T.P. Pharma Sci. 9: 447–455.

    Google Scholar 

  20. Arica, B., and Kas, H.S., 1997, Beyine ilac tasinmasi. Hacettepe Tip Dergisi 28: 4–14.

    Google Scholar 

  21. Filipovic-Grcic, J., Maysinger,D., Zorc, B., Jalsenjak, I., 1995, Macromolecular prodrugs IV. Alginate-chitosan microspheres of PHEA-L-Dopa adduct. Int. J Pharm. 116: 39–44.

    Article  Google Scholar 

  22. Maysinger, D., Jalsenjak, V., Stolnik, S., Jalsenjak, I., 1992, Release of L-Dopa from HSA microspheres into the cat brain: in vitro and in vivo characterization by microdialysis. In Microencapsulation of Drugs (T.L.Whateley, ed), Harwood Acad. Publ., Switzerland, pp. 269–275.

    Google Scholar 

  23. Arica, B., Kas, H.S., Hincal, A.A., 1997, Evaluation and formulation of biodegradable levodopa microspheres using 32 factorial design. 4th Int. Biomed Sci. Technol. Symp., pp. 9–11.

    Google Scholar 

  24. Arica, B., Kas, H.S., Hincal, A.A., 1997, Factors influencing the formulation parameters of biodegradable carbidopa microspheres. 11th Int. Symp. Microencapsulation p.55.

    Google Scholar 

  25. Yurasov, V.V., Kucheryanu, V.G., Kudrin, V.S., Zhigal-Tsev, I.V., Nikushkin, E.V., Sandalov, Y.G., Kapkin, A.P., Shvets, V.S., 1997, Effect of long term parenteral administration of empty and L-Dopa loaded liposomes on the turnover of dopamine and its metabolites in the striatum of mice with experimental Parkinson’s syndrome. Bull. Exp. Biol. Med., 123: 126–129.

    Article  Google Scholar 

  26. During, M.J., Freese, A., Sabel, B.A., 1989, Controlled release of dopamine from a polymeric brain implant: in vivo characterization. Ann. Neuro. 25: 351–356.

    Article  Google Scholar 

  27. Zhigaltsov, I.V., Kaplan, A.P., Kucheryanu, V.G., Kryzhanovsky, G.N., Kolomeichuk, S.N., Shvets, V.L., Yurasov, V.V., 2001, Liposomes containing dopamine entrapped in response to transmembrane ammonium sulphate gradient as carrier system for dopamine delivery into the brain of Parkinsonian mice. J. Liposome Res. 11: 55–71.

    Article  Google Scholar 

  28. Winn, S.R., Tresco, P.A., Zielinski, B., 1991, Behavioral recovery following intrastriatal implantation of microencapsulated PC 12 cells. Exp. Neurology 113: 322–329.

    Article  Google Scholar 

  29. Vallbacka, J.J., Nobrega, J.N., Sefton, M.V., 2001, Tissue engineering as a platform for controlled release of therapeutic agents: implantation of microencapsulated dopamine producing cells in the brain of rats. J Control.Rel. 72: 93–100.

    Article  Google Scholar 

  30. Howard, M.A., Gross, A., Glady, M.S., 1989, Intracerebral drug delivery in rats with lesion-induced memory deficits. J. Neurosurgery71: 105–112.

    Article  Google Scholar 

  31. Koseki, N., Takemoto, O., Sasaki, Y.,1996, A new application pf peptide drug delivery system to the brain. Proceed. Intern. Symp. Contol. Rel. Bioact. Mater. 23: 605–606.

    Google Scholar 

  32. Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., 1995, Passage of peptides through the blood-brain barrier with colloidal polymer nanoparticles. Brain Res. 674: 171–174.

    Article  Google Scholar 

  33. Alyautdin, R. N., Tezikov, E.B., Ramge, P., Kharkevich, D. A., Begley, D. J., Kreuter, J., 1998, Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: an in situ brain perfusion study. J. Microncapsulation 15: 67–74.

    Article  Google Scholar 

  34. Alyautdin, R. N., Petrov, V.E., Langer, R., Berthold, A., Kharkevich, D. A., Kreuter, J., 1997, Delivery of lorapamide across the blood-brain barrier with polysorbate 80-coated PBCA nanoparticles. Pharm. Res. 14: 324–328.

    Article  Google Scholar 

  35. Fallon P.A. and Whateley, T.L., 1994, The development and evaluation of poly(lacticglycolic acid) implants for sustained delivery of dexamethasone to the brain. Proceed. Intern. Symp. Contol. Rel. Bioact. Mater. 21: 364–365.

    Google Scholar 

  36. Eroglu, H., Kas, H.S., Oner, L., Turkoglu, O.F., Akalan, N., Sargon, M.F., Ozer, N., Hincal, A.A., 2000. In vitro / in vivo characterization of bovine serum albumin microspheres containing dexamethasone sodium phosphate, STP Pharm Sci. 10:303–308.

    Google Scholar 

  37. Eroglu, H., Kas, H.S., Oner, L., Turkoglu, O.F., Akalan, N., Sargon, M.F., Ozer, N., 2001, The in vitro and in vivo characterization of PLGA: L-PLA microspheres containing dexamethasone sodium phosphate. J. Microencapsulation 18: 603–612.

    Article  Google Scholar 

  38. Kas, H.S. and Arica, B., 1997, Delivery to brain by microparticles. Proc. Symp. Particulate Systems from Formulation to Production, pp. 123–124.

    Google Scholar 

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Kaş, H.S. (2004). Drug delivery to Brain by Microparticulate Systems. In: Hasirci, N., Hasirci, V. (eds) Biomaterials. Advances in Experimental Medicine and Biology, vol 553. Springer, Boston, MA. https://doi.org/10.1007/978-0-306-48584-8_17

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  • DOI: https://doi.org/10.1007/978-0-306-48584-8_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0988-9

  • Online ISBN: 978-0-306-48584-8

  • eBook Packages: Springer Book Archive

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