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Recommendations for Pregnancies in Patients with Crigler-Najjar Syndrome

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JIMD Reports - Case and Research Reports, 2012/4

Part of the book series: JIMD Reports ((JIMD,volume 7))

Abstract

During pregnancy, the developing foetus in mothers with Crigler-Najjar type 1 and 2 is exposed to raised levels of unconjugated bilirubin, with the risk of neurotoxicity. We describe two pregnancies in a patient with Crigler-Najjar type 2, who was carefully monitored prior to and during pregnancy and phototherapy adjusted to maintain serum bilirubin levels below 200 μmol/l and the bilirubin/albumin molar ratio below 50%. Both pregnancies resulted in normal delivery of healthy infants who had normal neurological development. A review of all reported pregnancies in Crigler-Najjar patients and a set of recommendations are presented.

Competing interests: None declared

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Internal medicine, metabolic diseases Office D416 Erasmus MC, 2040, 3000 CA, Rotterdam, The Netherlands

    J. H. Paul Wilson & Janneke G. Langendonk

  2. Department of Paediatrics, Erasmus MC, Rotterdam, The Netherlands

    Maarten Sinaasappel

  3. Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    Fred K. Lotgering

Authors
  1. J. H. Paul Wilson
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  2. Maarten Sinaasappel
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  3. Fred K. Lotgering
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  4. Janneke G. Langendonk
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Corresponding author

Correspondence to Janneke G. Langendonk .

Editor information

Editors and Affiliations

  1. , Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom

    Garry Brown

  2. Medical Center, Department of Pediatrics, Radboud University Nijmegen, Geert Grooteplein 9, Nijmegen, 6500 HB, Netherlands

    Eva Morava

  3. Heidelberg University Hospital, Center for Child and Adolescent Medicine, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany

    Verena Peters

  4. Biological Sciences, Michigan Technological University, 1400 Townsend Drive, Houghton, 49931, USA

    K Michael Gibson

  5. Division of Human Genetics, Medical University Innsbruck, Sch�pfstr. 41, Innsbruck, A-6020, AT

    Johannes Zschocke

Additional information

Communicated by: Robin Lachmann

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© 2012 SSIEM and Springer-Verlag Berlin Heidelberg

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Wilson, J.H.P., Sinaasappel, M., Lotgering, F.K., Langendonk, J.G. (2012). Recommendations for Pregnancies in Patients with Crigler-Najjar Syndrome. In: Brown, G., Morava, E., Peters, V., Gibson, K., Zschocke, J. (eds) JIMD Reports - Case and Research Reports, 2012/4. JIMD Reports, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8904_2012_142

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  • DOI: https://doi.org/10.1007/8904_2012_142

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-32441-3

  • Online ISBN: 978-3-642-32442-0

  • eBook Packages: MedicineMedicine (R0)

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