Skip to main content

Le basi genetiche dell’obesità

  • Chapter
Salute & equilibrio nutrizionale

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliografia

  1. Stunkard AJ, Sorensen TIA, Hanis C et al (1986) An adoption study of human obesity. New Engl J Med 314:193–198

    Article  PubMed  CAS  Google Scholar 

  2. Stunkard AJ, Foch TT, Hrubec Z (1986) A twin study of human obesity. JAMA 256:51–54

    Article  PubMed  CAS  Google Scholar 

  3. Stunkard AJ, Harris JR, Pedersen NL et al (1990) The body mass index of twins who have been reared apart. New Engl J Med 322:1483–1487

    Article  PubMed  CAS  Google Scholar 

  4. Faith MS, Pietrobelli A, Nunez C et al (1999) Evidence for independent genetic influences on fat mass and body mass index in a pediatric twin sample. Pediatrics 1:61–67

    Article  Google Scholar 

  5. Pausova Z, Gossad F, Goudet D et al (2001) Heritability estimates of obesity measures in siblings with and without hypertension. Hypertension 38:41–47

    PubMed  CAS  Google Scholar 

  6. Hunt MS, Katzmarzyk PT, Perusse L et al (2002) Familial resemblance of 7-year changes in body mass and adiposity. Obes Res 6:507–517

    Article  Google Scholar 

  7. Hausberger FX (1959) Behavior of transplanted adipose tissue of hereditarily obese mice. Anat Rec 135:109–113

    Article  PubMed  CAS  Google Scholar 

  8. Coleman DL, Hummel KP (1969) Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 217:1298–304

    PubMed  CAS  Google Scholar 

  9. Zhang Y, Proenca R, Maffei M et al (1994) Positional cloning of the mouse obese gene its human homologue. Nature 372:425–432

    Article  PubMed  CAS  Google Scholar 

  10. Tartaglia LA, Dembski M, Weng X et al (1995) Identification and expression cloning of a leptin receptor, Ob-R. Cell 83:1263–1271

    Article  PubMed  CAS  Google Scholar 

  11. Swartz MW, Seeley RJ, Woods SC et al (1997) Leptin increases hypotalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46:2119–2123

    Google Scholar 

  12. Barsh GS, Farooqui IS, O’Rahilly S (2000) Genetics of body-weight regulation. Nature 404:644–651

    PubMed  CAS  Google Scholar 

  13. Farooqi IS, Jebb SA, Langmack G et al (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341:879–84

    Article  PubMed  CAS  Google Scholar 

  14. Farooqi IS, Matarese G, Lord GM et al (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110:1093–1103

    Article  PubMed  CAS  Google Scholar 

  15. Hervey GR (1958) The effects of lesions in the hypotalamus in parabiotic rats. Am J Physiol 145:336–352

    Google Scholar 

  16. Gantz I, Miwa H, Konda Y et al (1993) Molecular cloning, expression, and gene localizzation of a fourth melanocortin receptor. J Biol Chem 268:15174–15179

    PubMed  CAS  Google Scholar 

  17. Montague CT, Farooqi IS, Whitehead JP et al (1997) Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 387:903–908

    Article  PubMed  CAS  Google Scholar 

  18. Clement K, Vaisse C, Lahlou N et al (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392:398–401

    Article  PubMed  CAS  Google Scholar 

  19. Krude H, Biebermann H, Luck W et al (1998) Severe early onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155–157

    Article  PubMed  CAS  Google Scholar 

  20. Challis BG, Pritchard LE, Creemers JW et al (2002) A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum Mol Genet 11:1997–2004

    Article  PubMed  CAS  Google Scholar 

  21. Vaisse C, Clement K, Guy-Grand B et al (1998) A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 20:113–4

    Article  PubMed  CAS  Google Scholar 

  22. Jackson RS, Creemers JW, Ohagi S et al (1997) Obesity and impaired prohormone processing asociated with mutations in the human prohormone convertase 1 gene. Nat Genet 16:303–306

    Article  PubMed  CAS  Google Scholar 

  23. Hinney A, Becker I, Heibult O et al (1998) Systematic mutation screening of the proopiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes. J Clin Endocrinol Metab 83:3737–3741

    Article  PubMed  CAS  Google Scholar 

  24. Yeo GS, Farooqi IS, Aminian S et al (1998) A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20:111–112

    Article  PubMed  CAS  Google Scholar 

  25. Hinney A, Schmidt A, Nottebom K et al (1999) Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. J Clin Endocrinol Metab 84:1483–6

    Article  PubMed  CAS  Google Scholar 

  26. Miraglia del Giudice E, Cirillo G, Nigro V et al (2002) Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with earlyonset obesity. Int J Obes Relat Metab Disord 26:647–651

    Article  PubMed  CAS  Google Scholar 

  27. Farooqui IS, Keogh JM, Yeo GSH et al (2003) Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085–95

    Article  Google Scholar 

  28. Branson R, Potoczna N, Kral JG et al (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 348:1096–1103

    Article  PubMed  CAS  Google Scholar 

  29. Hebebrand J, Geller F, Dempfle A et al (2004) Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. Mol Psychiatry 9:796–800

    Article  PubMed  CAS  Google Scholar 

  30. Miraglia del Giudice E, Santoro N, Cirillo G et al (2002) Mutational screening of CART gene in obese children: identifyng a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. Diabetes 50:2157–2160

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Italia, Milano

About this chapter

Cite this chapter

Perrone, L., Raimondo, P., Santoro, N., del Giudice, E.M. (2006). Le basi genetiche dell’obesità. In: Giovannini, M., Maffeis, C., Molinari, E., Scaglioni, S. (eds) Salute & equilibrio nutrizionale. Springer, Milano. https://doi.org/10.1007/88-470-0450-0_3

Download citation

  • DOI: https://doi.org/10.1007/88-470-0450-0_3

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0449-8

  • Online ISBN: 978-88-470-0450-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics