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Colonic and Anorectal Motility in Inflammatory Bowel Disease

  • Beatrice Salvioli
  • Gabriele Bazzocchi

Conclusions

Evidence in the literature reports motility abnormalities in patients with inflammatory bowel disorders. Many of the symptoms reported by patients derive from alteration in gut physiology. The mechanisms of this dysmotility are uncertain but different factors, either direct or indirect, of muscles and nerves can produce alteration of gut functions through the involvement of endocrine and neural networks.

We can summarize that entry of new ingesta into the colon during the postprandial period stimulates enteric mechanisms to initiate an excessive number of both high and low-amplitude propagating contractions. The decreased contractile function of the smooth muscle further helps acceleration of propulsion by decreasing segmental contractions and allowing forward movement of the colonic contents without impediments. The anorectal region is characterized by increased sensitivity to distension and reduced compliance

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Irritable Bowel Syndrome Vasoactive Intestinal Peptide Enteric Nervous System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Beatrice Salvioli
    • 1
  • Gabriele Bazzocchi
    • 2
  1. 1.Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi HospitalUniversity of BolognaBolognaItaly
  2. 2.Unit of Visceral Disorder and Autonomic Dysfunction Montecatone Rehabilitation InstituteUniversity of BolognaImolaItaly

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