Medical Therapy of Fistulizing Crohn’s Disease

  • Luigi Benini
  • Fosca De Iorio
  • Naika Tacchella
  • Italo Vantini


Treatment of CD fistulizing Crohn’s disease requires a close collaboration between the gastroenterologist and the surgeon. Antibiotics and immunomodulators such as azathioprine/6-mercaptopurine or methotrexate, if the patient is AZA-6MP intolerant/resistant, should be given early in the disease. In the case of resistance to immunomodulators, infliximab is the treatment of choice. Short-term cyclosporine A or tacrolimus may be tried in patients who fail to respond to infliximab. Abscesses should always be drained by an expert surgeon.


Mycophenolate Mofetil Perianal Fistula Oral Tacrolimus Fistula Healing Intravenous Cyclosporine 
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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • Luigi Benini
    • 1
  • Fosca De Iorio
    • 1
  • Naika Tacchella
    • 1
  • Italo Vantini
    • 1
  1. 1.Department of Biomedical and Surgical Sciences, Division of GastroenterologyPoliclinico “G.B. Rossi”VeronaItaly

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