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Fluid Resuscitation in Trauma

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Perioperative and Critical Care Medicine

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Abstract

Trauma is a complex and multiphasic disorder, with a precisely known initial time, an advanced phase characterised by a wide array of neurohormonal and immunological changes [1] and latter phases during which the deranged functions recover to a greater or lesser extent. These latter phases can last weeks or months and the passage from one to another is ill defined. There is a certain amount of evidence indicating that besides the severity of injures, the appropriateness of the initial approach heavily influences the clinical course and possibly the long term consequences of trauma [2]–[4]. There is also evidence that the inflammatory response can eventually lead to the development of Multiple Organ Dysfunction Syndrome (MODS) if primed by factors immediately after the trauma [5]. This has led to the concept of the ‘golden hour,’ a theoretical timeframe during which the biological response to trauma is triggered. During this critical period, every effort should be made to restore perfusion and tissue oxygenation in order to prevent the activation of mechanisms ultimately leading to widespread tissue inflammation and apoptosis [6], [7].

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Authors and Affiliations

  1. Department of Perioperative Medicine, Intensive Care and Emergency, School of Anaesthesia and Intensive Care, Cattinara University Hospital, Trieste, Italy

    G. Berlot

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  1. G. Berlot
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Editors and Affiliations

  1. Department of Perioperative Medicine, Intensive Care and Emergency, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo  & Giorgio Berlot  & 

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© 2006 Springer-Verlag Italia

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Berlot, G. (2006). Fluid Resuscitation in Trauma. In: Gullo, A., Berlot, G. (eds) Perioperative and Critical Care Medicine. Springer, Milano. https://doi.org/10.1007/88-470-0417-9_17

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  • DOI: https://doi.org/10.1007/88-470-0417-9_17

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0416-0

  • Online ISBN: 978-88-470-0417-7

  • eBook Packages: MedicineMedicine (R0)

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