Conclusions
It is quite impossible to force a diseased lung to comply to a constant high flow-rate of gas, and expect optimal alveolar distribution. Ideally, the medical respirator must have a flow-variable function, served by the back pressure as pulmonary structures are dilated by the inspiratory pressure producing the proximal-distal flow gradient into the lung.
Therefore, the development of ventilation and oxygen-exposure strategies to minimise lung injury is a priority for improving patient outcome. Moreover, good knowledge in basic pathophysiology remains the cornerstone to enable clinicians to design strategies with the aim of improving the management of patient-ventilator interaction.
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Bougatef, A. (2005). Neonatal Mechanical Ventilation. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/88-470-0351-2_7
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