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Is the acute respiratory distress syndrome a systemic disease?

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Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

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Clinical implications and conclusions

ARDS becomes a systemic disease in association with mechanical ventilation. There is an increasing amount of evidence in the literature showing that mechanical ventilation has a significant impacton the remote organ systems in ARDS. Research in VILI-associated MODS has focussed on the mechanisms of an up-regulated and imbalanced systemic inflammatory response and increased rates of apoptosis in the lungs and the remote organs as well as on impaired global and regional haemodynamics. Cellular and molecular biology research has suggested key elements in this context that may serve as therapeutic targets for future treatment of patients with ARDS.

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Authors and Affiliations

  1. Departments of Anaesthesia and Critical Care Medicine, Interdepartmental Division of Critical Care Medicine, Division of Respiratory Medicine, University of Toronto, St. Michael’s Hospital, Toronto, Canada

    L. Brander, A. S. Slutsky & H. Zhang

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  1. L. Brander
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  2. A. S. Slutsky
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  3. H. Zhang
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Editors and Affiliations

  1. Department of Perioperative Medicine, Intensive Care and Emergency, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo M.D. (Head) (Head)

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© 2005 Springer-Verlag Italia

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Brander, L., Slutsky, A.S., Zhang, H. (2005). Is the acute respiratory distress syndrome a systemic disease?. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/88-470-0351-2_35

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  • DOI: https://doi.org/10.1007/88-470-0351-2_35

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0288-3

  • Online ISBN: 978-88-470-0351-4

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