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Lessons we have learnt from microdialysis in animals and humans

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Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

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References

  1. Ungerstedt U, Pycock CH (1974) Functional correlates of dopamine neurotransmission. Bull Schweiz Akad Med Wiss 1278:1–5

    Google Scholar 

  2. Ungerstedt U (1991) Microdialysis — principles and application for studies in animal and man. J Intern Med 230:365–373

    Article  PubMed  CAS  Google Scholar 

  3. Meyerson BA, Linderoth B, Karlsson H et al (1990) Extracellular measurements in the thalamus of parkinsonian patients. Life Sci 46:301–308

    Article  PubMed  CAS  Google Scholar 

  4. Ungerstedt U, Herrera-Marschitz M, Jungnelius U et al (1982) Dopamine synaptic mechanisms reflected in studies combining behavioural recordings and brain dialysis. In: Kotisaka M et al (eds) Advances in dopamine research. Pergamon Press, New York, pp 219–231

    Google Scholar 

  5. Ungerstedt U, Bäckström T, Hallström Å et al (1997) Microdialysis in normal and injured human brain. In: Kinney JM, Tucker HN (eds) Physiology stress and malnutrition. Functional correlates, nutritional intervention. Lippincott-Raven, Philadelphia New York, pp 361–374

    Google Scholar 

  6. Hillered L, Valtysson J, Enblad P et al (1998) Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain. J Neurol Neurosurg Psychiatry 64:486–491

    Article  PubMed  CAS  Google Scholar 

  7. Hagström-Toft E, Arner P, Wahrenberg H et al (1993) Adrenergic regulation of human tissue metabolism in situ during mental stress. Endocrinol Metab 76:392–398

    Article  Google Scholar 

  8. Ungerstedt U (1984) Measurement of neurotransmitter release by intracranial dialysis. In: Marsden CA (ed) Measurement of neurotransmitter release in vivo. Wiley, New York, pp 8–107

    Google Scholar 

  9. Hutchinson PJ, O’Connell MT, Al-Rawi PG et al (2000) Clinical cerebral microdialysis: a methodological study. J Neurosurg 93:37–43

    Article  PubMed  CAS  Google Scholar 

  10. Tunblad K, Ederoth P, Gärdenfors A et al (2004) Altered blood-brain barrier transport of morphine in experimental meningitis studied with microdialysis. Acta Anaesthesiol Scand 48:294–301

    Article  PubMed  CAS  Google Scholar 

  11. Ederoth P, Tunblad K, Bouw R et al (2004) Blood-brain barrier transport of morphine in patients with severe brain trauma. Br J Clin Pharmacol 57:427–435

    Article  PubMed  CAS  Google Scholar 

  12. Blasberg RG, Fenstermacher JD, Patlack CS (1983) Transport of a-aminobutyric acid across brain capillary and cellular membranes. J Cereb Blood Flow Metab 3:8–12

    PubMed  CAS  Google Scholar 

  13. Hamberger A, Nyström B (1984) Extra-and intracellular amino acids in the hippocampusduring development of hepatic encephalopathy. Neurochem Res 9:1181–1192

    Article  PubMed  CAS  Google Scholar 

  14. Benveniste H, Drejer J, Shousboe A et al (1984) Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 43:1369–1374

    Article  PubMed  CAS  Google Scholar 

  15. Benveniste H, Diemer NH (1987) Cellular reactions to implantation of a microdialysis tube in the rat hippocampus. Acta Neuropathol (Berl) 74:234–238

    Article  PubMed  CAS  Google Scholar 

  16. Bolinder J, Ungerstedt U, Arner P (1993) Long-term continuous glucose monitoring with microdialysis in ambulatory insulin-dependent diabetic patients. Lancet 342:1080–1085

    Article  PubMed  CAS  Google Scholar 

  17. Bolinder J, Hagstrom-Toft E, Ungerstedt U et al (1997) Self-monitoring of blood glucose in type I diabetic patients: comparison with continuous microdialysis measurements of glucose in subcutaneous adipose tissue during ordinary life conditions. Diabetes Care 20:64–70

    PubMed  CAS  Google Scholar 

  18. Van den Berghe G, Wouters P, Weekers F et al (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345:1359–1367

    Article  PubMed  Google Scholar 

  19. Van den Berghe G, Wouters PJ, Bouillon R (2003) Outcome benefit of intensive insulin therapy in critically ill: insulin dose versus glycemic control. Crit Care Med 31:359–366

    Article  PubMed  CAS  Google Scholar 

  20. Lourido J, Ederoth P, Sundvall N et al (2002) Correlation between blood glucose concentration and glucose level in subcutaneous adipose tissue evaluated with microdialysis during neuro intensive care. Scand J Clin Lab Invest 62:285–292

    Article  PubMed  CAS  Google Scholar 

  21. Rosdahl H, Hamrin K, Ungerstedt U et al (1998) Metabolite levels in human skeletal muscle and adipose tissue studied with microdialysis at low perfusion flow. Am J Physiol 274:E936–E945

    PubMed  CAS  Google Scholar 

  22. Moberg E, Hagstrom-Toft E, Arner P (1997) Protracted glucose fall in subcutaneous adipose tissue and skeletal muscle compared with blood during insulin-induced hypoglycaemia. Diabetologia 40:1320–1326

    Article  PubMed  CAS  Google Scholar 

  23. Grände PO, Asgeirsson B, Nordström CH (2002) Volume targeted therapy of increased intracranial pressure: the Lund concept unifies surgical and non-surgical treatments. Acta Anaesthesiol Scand 46:929–941

    Article  PubMed  Google Scholar 

  24. Röjdmark J, Hedén P, Ungerstedt U (1998) Microdialysis-anew technique for free flap surveillance: methodological description. Eur J Plast Surg 21:344–348

    Article  Google Scholar 

  25. Röjdmark J, Blomqvist L, Malm M et al (1998) Metabolism in myocutaneous flaps studied by in situ microdialysis. Scand J Plast Reconstruct Hand Surg 32:27–34

    Article  Google Scholar 

  26. Setälä LP, Korvenoja EMJ, Härmä MA et al (2004) Glucose, lactate, and pyruvate response in an experimental model of microvascular flap ischemia and reperfusion: a microdialysis study. Microsurgery 24:223–231

    Article  PubMed  Google Scholar 

  27. Nowak G, Ungerstedt J, Wernerman J et al (2002) Metabolic changes in the liver graft monitored continuously with microdialysis during liver transplantation in a pig model. Liver Transplant 8:424–432

    Article  Google Scholar 

  28. Nowak G, Ungerstedt J, Wernerman J et al (2002) Clinical experiences in continuous graft monitoring with microdialysis early after liver transplantation. Br J Surg 89:1169–1175

    Article  PubMed  CAS  Google Scholar 

  29. Sommer T (2004) Microdialysis in the assessment of regional intestinal ischemia. Doctoral thesis, Center of Sensory-motor Interaction, Aalborg University, Denmark

    Google Scholar 

  30. Ungerstedt J, Nowak G, Ericzon BG et al (2003) Intraperitoneal microdialysis (IPM): a new technique for monitoring intestinal ischemia studied in a porcine model. Shock 20:91–96

    Article  PubMed  Google Scholar 

  31. Jansson K, Ungerstedt J, Jonsson T et al (2003) Human intraperitoneal microdialysis: increased lactate/pyruvate ratio suggests early visceral ischemia. A pilot study. Scand J Gastroenterol 38:1007–1011

    Article  CAS  Google Scholar 

  32. Jansson K, Redler B, Truedsson L et al (2004) Intraperitoneal cytokine response after major surgery: higher postoperative intraperitoneal versus systemic cytokine levels suggest the gastrointestinal tract as a major source of the postoperative inflammatory reaction. Am J Surg 187:373–377

    Article  CAS  Google Scholar 

  33. Jansson K, Redler B, Truedsson L et al (2004) Postoperative on-line monitoring with intraperitoneal microdialysis (IPM) is a sensitive clinical method for measuring increased anaerobic metabolism that correlates to cytokine response. Scand J Gastroenterol 39:434–439

    Article  PubMed  CAS  Google Scholar 

  34. Jansson K, Strand I, Redler B et al (2004) Results of intraperitoneal microdialysis depend on the location of the catheter. Scand J Clin Lab Invest 64:63–70

    Article  PubMed  CAS  Google Scholar 

  35. Siesjö BK (1978) Brain energy metabolism. Wiley, Chichester New York Brisbane

    Google Scholar 

  36. Ståhl N, Schalén W, Ungerstedt U et al (2003) Bedside biochemical monitoring of the penumbra zone surrounding an evacuated acute subdural haematoma. Acta Neurol Scand 108:211–215

    Article  PubMed  Google Scholar 

  37. Rosdahl H, Hamrin K, Ungerstedt U et al (2000) A microdialysis method for the in situ investigation of the action of large peptide molecules in human skeletal muscle: detection of local metabolic effects of insulin. Int J Biol Macromol 28:69–73

    Article  PubMed  CAS  Google Scholar 

  38. Alfredson H, Thorsen K, Lorentzon R (1999) In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain. Knee Surg Sports Traumatol Arthrosc 7:378–381

    Article  PubMed  CAS  Google Scholar 

  39. Alfredsson H, Lorentzon R (2003) Intratendinous glutamate levels and eccentric training in chronic Achilles tendinosis: a prospective study using microdialysis technique. Knee Surg Sports Traumatol Arthrosc 11:196–199

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Neuroscience, Division of Neurosurgery, University Hospital, Lund, Sweden

    C. H. Nordström

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  1. C. H. Nordström
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Editor information

Editors and Affiliations

  1. Department of Perioperative Medicine, Intensive Care and Emergency, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo M.D. (Head) (Head)

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Nordström, C.H. (2005). Lessons we have learnt from microdialysis in animals and humans. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/88-470-0351-2_12

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  • DOI: https://doi.org/10.1007/88-470-0351-2_12

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0288-3

  • Online ISBN: 978-88-470-0351-4

  • eBook Packages: MedicineMedicine (R0)

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