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Chemotherapy in Rectal Cancer

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Rectal Cancer
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References

  1. NIH Consensus Conference (1990) Adjuvant therapy for patients with colon and rectal cancer. JAMA 264:1444–1450

    Google Scholar 

  2. Gastrointestinal Tumor Study Group (1984) Adjuvant therapy of colon cancer: results of a prospectively randomized trial. N Engl J Med 312:1465

    Google Scholar 

  3. Krook JE, Moertel CG, Gunderson LL et al (1991) Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 324:709

    CAS  PubMed  Google Scholar 

  4. Fisher B, Wolmark N, Rockette H et al (1988) Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01. J Natl Cancer Inst 80:21–29

    CAS  PubMed  Google Scholar 

  5. O’Connel MJ, Martenson JA, Wieand HS et al (1994) Improving adjuvant therapy for rectal cancer by combining protected infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 331: 502–507

    Google Scholar 

  6. Gastrointestinal Tumor Study Group (1992) Radiation therapy and fluorouracil with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. J Clin Oncol 10:549–557

    Google Scholar 

  7. Tepper JE, O’Connel MJ, Petroni JR et al (1997) Adjuvant postoperative fluorouracil-modulated chemotherapy combined with pelvic radiation therapy for rectal cancer: initial results of intergroup 0114. J Clin Oncol 15:2030–2039

    CAS  PubMed  Google Scholar 

  8. Andre T, Boni C, Mounedji-Boudiaf L et al and the Multicenter International Study of Oxaliplatin/5-Fluorouracil/ Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators (2004) Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350:2343–2351

    Article  CAS  PubMed  Google Scholar 

  9. Willett CG, Shellito PC, Rodkey GV, Wood WC (1991) Preoperative irradiation for tethered rectal carcinoma. Radiother Oncol 21:141–142

    Article  CAS  PubMed  Google Scholar 

  10. Dosoretz DE, Gunderson LL, Hedberg S et al (1983) Preoperative irradiation for unresectable rectal and rectosigmoid carcinomas. Cancer 52:814–818

    CAS  PubMed  Google Scholar 

  11. Emami B, Pilepich M, Willet C et al (1982) Effect of preoperative irradiation on resectability of colorectal carcinomas. Int J Radiat Oncol Biol Phys 8:1295–1299

    CAS  PubMed  Google Scholar 

  12. Minsky BD, Cohen AM, Enker WE et al (1991) Radiation therapy for unresectable rectal cancer. Int J Radiat Oncol Biol Phys 21:1283–1289

    CAS  PubMed  Google Scholar 

  13. Moertel CG, Gunderson LL, Maillard JA et al (1994) Early evaluation of combined fluorouracil and leucovorin as a radiation enhancer for locally unresectable, residual, or recurrent gastrointestinal carcinoma. J Clin Oncol 12:21–27

    CAS  PubMed  Google Scholar 

  14. Petrelli N, Herrera L, Rustum Y et al (1987) A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 5:1559–1565

    CAS  PubMed  Google Scholar 

  15. Erlichman C, Fine S, Wong A, Elkahim T (1988) A randomized trial fluorouracil and folin acid in patients with metastatic colorectal carcinoma. J Clin Oncol 6:469–475

    CAS  PubMed  Google Scholar 

  16. Byfield JE, Frankel SS, Hombeck CL et al (1985) Phase I and pharmacologic study of 72 hour infused and hyperfractionated cyclical radiation. Int J Radiat Oncol Biol Phys 11:791–800

    CAS  PubMed  Google Scholar 

  17. Rotman M, Aziz H (1990) Concomitant continuous infusion chemotherapy and radiation. Cancer 65:823–835

    CAS  PubMed  Google Scholar 

  18. Minsky BD, Cohen AM, Kemery M et al (1992) Enhancement of radiation-induced downstaging of cancer by fluorouracil and high-dose leucovorin chemotherapy. J Clin Oncol 10:79–84

    CAS  PubMed  Google Scholar 

  19. Chan A, Wong A, Langevin J, Khoo R (1993) Preoperative concurrent 5-fluorouracil infusion, mitomycin C and pelvic radiation therapy in tethered and fixed rectal carcinoma. Int J Radiat Oncol Biol Phys 25:791–799

    CAS  PubMed  Google Scholar 

  20. Lokich JJ, Ahlgren JD, Gullo JJ et al (1989) A prospective randomized comparison of continuous infusion fluorouracil with conventional bolus schedule in metastatic colorectal carcinoma: a mid-Atlantic oncology program study. J Clin Oncol 7:425–432

    CAS  PubMed  Google Scholar 

  21. Rich TA, Skibber JM, Ajani JA et al (1995) Preoperative infusional chemoradiation therapy for stage T3 rectal cancer. Int J Radiat Oncol Biol Phys 32:1025–1029

    CAS  PubMed  Google Scholar 

  22. Chen ET, Mohiuddin M, Brodovsky H et al (1994) Downstaging of advanced rectal cancer following preoperative chemotherapy and high dose radiation. Int J Radiat Oncol Biol Phys 30:169–175

    CAS  PubMed  Google Scholar 

  23. Gerard B, Bleiberg H, Van Daele D et al (1998) Oxaliplatin combined to 5-fluorouracil and folinic acid: an effective therapy in patients with advanced colorectal cancer. Anticancer Drugs 9:301–305

    CAS  PubMed  Google Scholar 

  24. Giacchetti S, Itzhaki M, Gruia G et al (1999) Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery. Ann Oncol 10:663–669

    Article  CAS  PubMed  Google Scholar 

  25. Arnould S, Hennebelle I, Canal P et al (2003) Cellular determinants of oxaliplatin sensitivity in colon cancer cell lines. Eur J Cancer 39:112–119

    Article  CAS  PubMed  Google Scholar 

  26. Gerard JP, Chapet O, Nemoz C et al (2003) Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: The Lyon R0-04 phase II trial. J Clin Oncol 21:1119–1124

    Article  PubMed  Google Scholar 

  27. Aschele C, Friso ML, Pucciarelli S et al (2004) Phase I study of weekly oxaliplatin (oxa) + 5-fluorouracil (5-FU) continuous infusion in combination with preoperative radiotherapy in locally advanced rectal cancer. Ann Oncol 16:140–1146

    Google Scholar 

  28. Oliani C, Romano M et al (2000) Regional hyperthermia (RTH), radiotherapy (RT) and chemotherapy (CT) in the preoperative treatment of rectal cancer: a preliminary study. 36th Annual Meeting ASCO 19:302

    Google Scholar 

  29. Carraro S, Roca EL, Cartelli C et al (2002) Radiochemotherapy with short daily infusion of low-dose oxaliplatin, leucovorin, and 5-FU in T3-T4 unresectable rectal cancer: a phase II IATTGI study. Int J Radiat Oncol Biol Phys 54:397–402

    Article  CAS  PubMed  Google Scholar 

  30. Diaz-Rubio E, Evans TR, Tabemero J et al (2000) Phase I study of capecitabine in combination with oxaliplatin in patients with advanced or metastatic solid tumors. Onkologie 23[Suppl 5]:23

    Google Scholar 

  31. Kim JS, Cho MJ, Song KS, Yoon WH (2002) Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 54:403–408

    CAS  PubMed  Google Scholar 

  32. Rodel C, Grabenbauer GG, Papadopoulos T et al (2003) Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer. J Clin Oncol 21:3098–3104

    Article  PubMed  Google Scholar 

  33. Sauer R, Becker H, Hohenberger W et al and German Rectal Cancer Study Group (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731–1740

    Article  CAS  PubMed  Google Scholar 

  34. Willett CG, Boucher Y, di Tomaso E et al (2004) Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10:145–147

    CAS  PubMed  Google Scholar 

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© 2005 Springer-Verlag Italia

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Padovani, M., Oliani, C. (2005). Chemotherapy in Rectal Cancer. In: Rectal Cancer. Springer, Milano. https://doi.org/10.1007/88-470-0343-1_24

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  • DOI: https://doi.org/10.1007/88-470-0343-1_24

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0342-2

  • Online ISBN: 978-88-470-0343-9

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