Skip to main content

Are a Single Measurement of Troponin-I and C-Reactive Protein of Clinical Significance in Patients with Acute Coronary Syndromes?

  • Conference paper
Emerging Pathologies in Cardiology
  • 457 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Braunwald E (1998) Unstable angina: an etiologic approach to management. Circulation 98:2219–2222

    PubMed  CAS  Google Scholar 

  2. Ottani F, Galvani M, Nicolini FA et al (2000) Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes. Am Heart J 140:917–927

    Article  PubMed  CAS  Google Scholar 

  3. Braunwald E, Antman EM, Beasley JW et al (2000) ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: executive summary and recommendations. Circulation 102: 1193–1209

    PubMed  CAS  Google Scholar 

  4. Bertrand ME, Simoons ML, Fox KAA et al (2000) Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation. Recommendations of the Task Force of the European Society of Cardiology. Eur Heart J 21:1406–1432

    Article  PubMed  CAS  Google Scholar 

  5. Sabatine MS, Morrow DA, de Lemos JA et al (2002) Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide. Circulation 105:1760–1763

    Article  PubMed  CAS  Google Scholar 

  6. Galvani M, Ottani F, Oltrona L et al (2004) N-terminal pro-brain natriuretic peptide on admission has prognostic value across the whole spectrum of acute coronary syndromes. Circulation 110:128–134

    Article  PubMed  CAS  Google Scholar 

  7. Oltrona L, Ottani F, Galvani M (2004) Clinical significance of a single measurement of troponin-I and C-reactive protein at admission in 1773 consecutive patients with acute coronary syndromes. Am Heart J 148:405–415

    Article  PubMed  CAS  Google Scholar 

  8. Morrow DA (2001) Troponins in patients with acute coronary syndromes: biologic, diagnostic, and therapeutic implications. Cardiovascular Toxicology 1:105–110

    Article  PubMed  CAS  Google Scholar 

  9. Ross R (1999) Atherosclerosis — an inflammatory disease. N Engl J Med 340:115–126

    Article  PubMed  CAS  Google Scholar 

  10. Ridker PM, Cushman M, Stampfer MJ et al (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336:973–979

    Article  PubMed  CAS  Google Scholar 

  11. Ridker PM, Hennekens CH, Buring JE et al (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836–843

    Article  PubMed  CAS  Google Scholar 

  12. Haverkate F, Thompson SG, Pyke SD et al (1997) The European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Production of C-reactive protein and risk of coronary events in stable and unstable angina. Lancet 349:462–466

    Article  PubMed  CAS  Google Scholar 

  13. Toss H, Lindahl B, Siegbahn A et al (1997) the FRagmin during InStability in Coronary artery disease (FRISC) Study Group. Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. Circulation 96:4204–4210

    PubMed  CAS  Google Scholar 

  14. Lindahl B, Toss H, Siegbahn A et al (2000) the FRagmin during InStability in Coronary artery disease (FRISC) Study Group. Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. N Engl J Med 343:1139–1147

    Article  PubMed  CAS  Google Scholar 

  15. Heeschen C, Hamm CW, Bruemmer J et al (2000) The Chimeric c7E3 AntiPlatelet Therapy in Unstable angina REfractory to standard treatment (CAPTURE) Investigators. Predictive value of C-reactive protein and troponin T in patients with unstable angina: a comparative analysis. J Am Coll Cardiol 35:1535–1542

    Article  PubMed  CAS  Google Scholar 

  16. Morrow DA, Rifai N, Antman EM et al (1998) C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a Thrombolysis In Myocardial Infarction (TIMI-11A) substudy. J Am Coll Cardiol 31:1460–1465

    Article  PubMed  CAS  Google Scholar 

  17. Libby P, Ridker PM, Maseri A (2002) Inflammation and atherosclerosis. Circulation 105:1135–1143

    Article  PubMed  CAS  Google Scholar 

  18. Pasceri V, Willerson JT, Yeh ET (2000) Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102:2165–2168

    PubMed  CAS  Google Scholar 

  19. Lee TH, Juarez G, Cook EF et al (1991) Ruling out acute myocardial infarction: a prospective multicenter validation of a 12-hour strategy for patients at low risk. N Engl J Med 324:1239–1246

    Article  PubMed  CAS  Google Scholar 

  20. Hamm CW, Goldmann B, Heeschen C et al (1997) Emergency room triage of patients with acute chest pain based on rapid testing for troponin T or troponin I. N Engl J Med 337:1648–1653

    Article  PubMed  CAS  Google Scholar 

  21. Anonymous (1979) Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology/World Health Organization Task Force on Standardization of Clinical Nomenclature. Circulation 59:607–608

    Google Scholar 

  22. Alpert J, Thygesen K for the Joint European Society of Cardiology/American College of Cardiology Committee (2000) Myocardial infarction redefined — a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. Eur Heart J 21:1502–1513

    Article  Google Scholar 

  23. Panteghini M, Apple FS, Christenson RH et al (1999) Use of biochemical markers in acute coronary syndromes. Clin Chem Lab Med 37:687–693

    Article  PubMed  CAS  Google Scholar 

  24. Jaffe AS, Ravkilde J, Roberts R et al (2000) It’s time for a change to a troponin standard. Circulation 102:1216–1220

    PubMed  CAS  Google Scholar 

  25. Hamm CW (2001) Acute coronary syndromes. The diagnostic role of troponins. Thromb Res 103:S63–S69

    Article  PubMed  CAS  Google Scholar 

  26. Panteghini M, Pagani F, Bonetti G (1999) The sensitivity of cardiac markers: an evidence-based approach. Clin Chem Lab Med 37:1097–1106

    Article  PubMed  CAS  Google Scholar 

  27. Panteghini M, Cuccia C, Pagani F et al (2002) Coronary angiographic findings in patients with clinical unstable angina according to cardiac troponin I and T concentrations in serum. Arch Pathol Lab Med 126:448–451

    PubMed  Google Scholar 

  28. Morrow DA, Cannon CP, Rifai N et al (2001) Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction: results from a randomized trial. JAMA 286:2405–2412

    Article  PubMed  CAS  Google Scholar 

  29. Baldus S, Heeschen C, Meinertz T et al (2003) Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 108:1440–1445

    Article  PubMed  CAS  Google Scholar 

  30. Heeschen C, Dimmeler S, Fichtlscherer S et al (2004) Prognostic value of placental growth factor in patients with acute chest pain. JAMA 291:435–441

    Article  PubMed  CAS  Google Scholar 

  31. James S, Armstrong P, Califf R et al (2003) Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial. Am J Med 115:178–184

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Italia

About this paper

Cite this paper

Oltrona, L., Pirola, R. (2005). Are a Single Measurement of Troponin-I and C-Reactive Protein of Clinical Significance in Patients with Acute Coronary Syndromes?. In: Gulizia, M.M. (eds) Emerging Pathologies in Cardiology. Springer, Milano . https://doi.org/10.1007/88-470-0341-5_2

Download citation

  • DOI: https://doi.org/10.1007/88-470-0341-5_2

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0311-8

  • Online ISBN: 978-88-470-0341-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics