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Multiscale Modelling of Lymphatic Drainage

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Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 14))

Abstract

In this chapter we will describe the latest developments in the area of lymphatic modelling. The lymphatic system is one of the key elements of the human circulation, serving the dual functions of draining interstitial fluid and returning this to the general blood circulation, together with processing this lymph fluid which is a key component of the body’s immune response system. Compared to the main cardiovascular system however, remarkably little modelling has been attempted. At the same time, the distribution of pumping activity (contractile lymphangions coupled with simple valves) throughout the system, passive primary lymphatics and complex lymph nodes combining to form an active network, makes the system a prime candidate for multiscale modelling.

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Acknowledgments

Tiina Roose acknowledges the award of a Royal Society University Research Fellowship to fund her research.

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Authors and Affiliations

  1. Bioengineering Sciences Research Group, Faculty of Engineering and Environment, University of Southampton, Southampton, UK

    Tiina Roose

  2. College of Engineering, Maths and Physical Sciences, University of Exeter, Exeter, UK

    Gavin Tabor

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  1. Tiina Roose
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  2. Gavin Tabor
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Correspondence to Tiina Roose .

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Editors and Affiliations

  1. Tel Aviv University, Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv, 69978, Israel

    Amit Gefen

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Roose, T., Tabor, G. (2013). Multiscale Modelling of Lymphatic Drainage. In: Gefen, A. (eds) Multiscale Computer Modeling in Biomechanics and Biomedical Engineering. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2012_148

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  • DOI: https://doi.org/10.1007/8415_2012_148

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