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In Vivo, In Vitro, In Silico: Computational Tools for Product and Process Design in Tissue Engineering

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Computational Modeling in Tissue Engineering

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 10))

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Abstract

This chapter aims to provide an introduction to how engineering tools in general and computational models in particular can contribute to advancing the tissue engineering (TE) field. After a description of the current state of the art of TE, the developmental engineering paradigm is briefly discussed. Subsequently an overview is provided of different model categories that focus on different aspects of TE. These categories consists of the models that focus on either the TE product, the TE process or the in vivo results obtained after implantation. Generally, in all these models the aim is firstly to understand the biological process at hand and secondly to design strategies in silico to enhance the desired in vitro or in vivo behaviour. Finally, the need for quantification and parameter determination is discussed along with the computational tools and models that can be used to design the thereto required experiments in the most intelligent way.

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Acknowledgments

The author gratefully acknowledges funding from the Special Research Fund of the University of Liège (FRS.D-10/20), the Belgian National Fund for Scientific Research (FNRS) grant FRFC 2.4564.12 and the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007–2013)/ERC grant agreement n°279100. The authors also gratefully acknowledges collaborators from the Biomechanics Research Group of the University of Liège and from Prometheus, the KU Leuven Research and Development Division of Skeletal Tissue Engineering (www.kuleuven.be/Prometheus) for their invaluable input.

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  1. Biomechanics Research Unit, University of Liège, Chemin des Chevreuils 1 B52/3, 4000, Liège, Belgium

    Liesbet Geris

  2. Prometheus, Division of Skeletal Tissue Engineering Leuven, KU Leuven, Herestraat 49, box 813, 3000, Leuven, Belgium

    Liesbet Geris

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    Liesbet Geris

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Geris, L. (2012). In Vivo, In Vitro, In Silico: Computational Tools for Product and Process Design in Tissue Engineering. In: Geris, L. (eds) Computational Modeling in Tissue Engineering. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2012_144

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  • DOI: https://doi.org/10.1007/8415_2012_144

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