Skip to main content

Dynamic Material Properties of Human and Animal Livers

  • Chapter
  • First Online:
Soft Tissue Biomechanical Modeling for Computer Assisted Surgery

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 11))

Abstract

Accurate characterization of the mechanical properties of soft tissues is important for diagnosing medical pathologies and developing solutions for them. With the recent advances in technologies leading to the development of surgical simulators, medical robots, and computer-assisted surgical planning systems, this topic has gained even more importance. However, most of the earlier research studies conducted with animal and human livers have focused on the investigation of static (strain-dependent) material properties. The number of studies investigating the dynamic material properties (time and frequency-dependent) of animal and human livers are much less than the ones investigating the static material properties. In fact, there is almost no data available in the literature showing the variation in dynamic material properties of healthy or diseased human liver as a function of excitation frequency.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Fung, Y.C.: Biomechanics: Mechanical Properties of Living Tissues. Springer, New York (1993)

    Google Scholar 

  2. Hu, T., Lau, A., Desai, J.: Instrumentation for testing soft tissue undergoing large deformation: ex vivo and in vivo studies. J. Med. Devices 2, 041001 (2008)

    Article  Google Scholar 

  3. Kauer, M: Inverse finite element characterization of soft tissues with aspiration experiments. Ph.D. Thesis, Institute of Mechanical Systems, Dissertation No: 14233, ETH Zurich (2001).

    Google Scholar 

  4. Kerdok, A.E., Ottensmeyer, M.P., Howe, R.D.: Effects of perfusion on the viscoelastic characteristics of liver. J. Biomech. 39(12), 2221–2231 (2006)

    Article  Google Scholar 

  5. Kiss, M.Z., Varghese, T., Hall, T.J.: Viscoelastic characterization of in vitro canine tissue. Phys. Med. Biology 49(18), 4207–4218 (2004)

    Article  Google Scholar 

  6. Kruse, S.A., Smith, J.A., Lawrence, A.J., Dresner, M.A., Manduca, A., Greenleaf, J.F., Ehman, R.L.: Tissue characterization using magnetic resonance elastography: Preliminary results. Phys. Med. Biology 45(6), 1579–1590 (2000)

    Article  Google Scholar 

  7. Liu, Z., Bilston, L.: On the viscoelastic character of liver tissue: experiments and modeling of the linear behavior. Biorheology 37(3), 191–201 (2000)

    Google Scholar 

  8. Manduca, A., Oliphant, T.E., Dresner, M.A., Mahowald, J.L., Kruse, S.A., Amromin, E., Felmlee, J.P., Greenleaf, J.F., Ehman, R.L.: Magnetic resonance elastography: Non-invasive mapping of tissue elasticity. Med. Imag. Analysis 5(4), 237–254 (2001)

    Article  Google Scholar 

  9. Mazza, E., Nava, A., Hahnloser, D., Jochum, W., Bajka, M.: The mechanical response of human liver and its relation to histology: An in vivo study. Med. Imag. Analysis 11, 663–672 (2007)

    Article  Google Scholar 

  10. Nava, A., Mazza, E., Furrer, M., Villiger, P., Reinhart, W.H.: In vivo mechanical characterization of human liver. Med. Imag. Analysis 12, 203–216 (2008)

    Article  Google Scholar 

  11. Ocal, S., Ozcan, M.U., Basdogan, I., Basdogan, C.: Effect of preservation period on the viscoelastic material properties of soft tissues with implications for liver transplantation. J. Biomech. Eng. 132(10), 101007 (2010)

    Article  Google Scholar 

  12. Ottensmeyer, MP, Kerdok, AE, Howe, RD, Dawson, SL: The effects of testing environment on the viscoelastic properties of soft tissues. Proceeding of International Symposium on Medical Simulation, 9–18 (2004)

    Google Scholar 

  13. Ozcan, M.U., Ocal, S., Basdogan, C., Dogusoy, G., Tokat, Y.: Characterization of frequency-dependent material properties of human liver and its pathologies using an impact hammer. Med. Imag. Analysis 15(1), 45–52 (2011)

    Article  Google Scholar 

  14. Rosen, J., Brown, J.D., De, S., Sinanan, M., Hannaford, B.: Biomechanical properties of abdominal organs in vivo and postmortem under compression loads. J. Biomech. Eng. 130(2), 021020 (2008)

    Article  Google Scholar 

  15. Samur, E., Sedef, M., Basdogan, C., Avtan, L., Duzgun, O.: A robotic indenter for minimally invasive measurement and characterization of soft tissue behavior. Med. Imag. Analysis 11(4), 361–373 (2007)

    Article  Google Scholar 

  16. Sandrin, L., Fourquet, B., Hasquenoph, J.M., Yon, S., Fournier, C., Mal, F., Christidis, C., Ziol, M., Poulet, B., Kazemi, F., Beaugrand, M., Palau, R.: Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med. Biology 29(12), 1705–1713 (2003)

    Article  Google Scholar 

  17. Saraf, H., Ramesh, K.T., Lennon, A.M., Merkle, A.C., Roberts, J.C.: Mechanical properties of soft human tissues under dynamic loading. J Biomech 40(9), 1960–1967 (2007)

    Article  Google Scholar 

  18. Tay, B.K., Kim, J., Srinivasan, M.A.: In vivo mechanical behavior of intra-abdominal organs. IEEE Trans Biomedical Eng 53(11), 2129–2138 (2006)

    Article  Google Scholar 

  19. Valtorta, D., Mazza, E.: Dynamic measurement of soft tissue viscoelastic properties with a torsional resonator device. Med. Imag. Analysis 9, 481–490 (2005)

    Article  Google Scholar 

  20. Zhang, M., Castaneda, B., Wu, Z., Nigwekar, P., Joseph, J., Rubens, D.J., Parker, K.J.: Congruence of imaging estimator and mechanical measurements of viscoelastic properties of soft tissues. Ultrasound Med. Biology 33(10), 1617–1631 (2007)

    Article  Google Scholar 

Download references

Acknowledgments

The Scientific and Technological Research Council of Turkey supported the scientific works discussed in this chapter under the contracts MAG-104M283, MAG-110M649, and the student fellowship program BIDEB-2210.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cagatay Basdogan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Basdogan, C. (2012). Dynamic Material Properties of Human and Animal Livers. In: Payan, Y. (eds) Soft Tissue Biomechanical Modeling for Computer Assisted Surgery. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2012_122

Download citation

  • DOI: https://doi.org/10.1007/8415_2012_122

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-29013-8

  • Online ISBN: 978-3-642-29014-5

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics