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Thoracic Aortic Aneurysms—Clinical Assessment and Treatment

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Biomechanics and Mechanobiology of Aneurysms

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 7))

Abstract

Aneurysmal dilatation of the aorta can occur along all the 3 divisions of the thoracic aorta and most commonly affect males in the sixth and seventh decade of life. These aneurysms, if remained un-noticed, grow and eventually dissect or rupture (or both). They are mostly degenerative in nature and are often discovered incidentally. A number of diagnostic modalities are used to diagnose them and Computed Tomography (CT) of the Aorta, has revolutionized the way we diagnose, follow and treat these aneurysms using different semi-automated algorithms. Proximal thoracic aneurysms (ascending and arch) are predominantly treated using an open approach, whereas distal aneurysms (descending) can be treated utilizing either an open or an endovascular approach, with the endovascular approach being favored for degenerative descending aortic aneurysms. More extensive aneurysms can be treated using hybrid procedures. The knowledge of different engineering principles, such as biomechanics of the thoracic aorta and computational flow dynamics has allowed us to understand the forces acting on these thoracic endografts and has and will provide further insights on how to modify the currently available devices and eventually patient outcomes.

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Authors and Affiliations

  1. Departments of Vascular and Endovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA

    Moqueet A. Qureshi & Roy K. Greenberg

  2. Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA

    Roy K. Greenberg

  3. Biomedical Engineering, Cleveland Clinic Foundation, Desk H32, 9500 Euclid Avenue, Cleveland, OH, USA

    Brain D. Conway & Roy K. Greenberg

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  1. Moqueet A. Qureshi
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Correspondence to Roy K. Greenberg .

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  1. Dept. Mechanical and Aerospace, Engineering, University Limerick, Limerick, Ireland

    Tim McGloughlin

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Qureshi, M.A., Conway, B.D., Greenberg, R.K. (2011). Thoracic Aortic Aneurysms—Clinical Assessment and Treatment. In: McGloughlin, T. (eds) Biomechanics and Mechanobiology of Aneurysms. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2011_75

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