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Computational Analysis of Displacement Forces Acting on Endografts Used to Treat Aortic Aneurysms

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Biomechanics and Mechanobiology of Aneurysms

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 7))

Abstract

Endovascular repair has greatly reduced the perioperative morbidity and mortality of abdominal aortic aneurysm repair compared to open surgery (Zarins et al., J. Vasc. Surg 38(6): 1264–1272, 2003). However, endovascular stent-grafts are exposed to a number of clinical complications, such as endograft migration (i.e., loss of positional stability), stent fractures and endoleaks (i.e., persistence of blood flow into the aneurysm sac after device placement). These complications may result in life-threatening and costly events such as aneurysm growth, rupture, need for secondary procedures, and life-long follow-up with imaging studies. Understanding the biomechanical environment experienced by endografts in vivo is a critical factor in improving their performance (Figueroa et al., J. Endovasc. Ther 16(3):350–358, 2009; 284–294, 2009). The loads experienced by aortic endografts are greatly dependent on the tortuosity and size of the endograft, as well as on the hemodynamic state of the patient. The fixation response of the endograft is determined by factors such as the fixation mechanism (radial pressure vs. hooks and barbs), amount of “landing zone” (i.e., area where the endograft can physically attach to the aorta), and the disease state of the vessel wall at the landing zone. The purpose of this study is to review the most common complications associated with endovascular repair of abdominal and thoracic aneurysms, and to provide a summary of the state of the art of the computational tools used to perform patient-specific modeling of endograft dynamics.

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Acknowledgments

This research was supported by the National Institutes of Health (Grants P50 HL083800, and 1 RC1 EB011443-01) and the National Science Foundation (Grant CNS-0619926).

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Authors and Affiliations

  1. Department of Bioengineering, Stanford University, Stanford, CA, USA

    C. Alberto Figueroa

  2. Department of Surgery, Stanford University, Stanford, CA, USA

    Christopher K. Zarins

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  1. C. Alberto Figueroa
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Correspondence to Christopher K. Zarins .

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  1. Dept. Mechanical and Aerospace, Engineering, University Limerick, Limerick, Ireland

    Tim McGloughlin

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Figueroa, C., Zarins, C.K. (2011). Computational Analysis of Displacement Forces Acting on Endografts Used to Treat Aortic Aneurysms. In: McGloughlin, T. (eds) Biomechanics and Mechanobiology of Aneurysms. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2011_73

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  • DOI: https://doi.org/10.1007/8415_2011_73

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