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Active Implants and Scaffolds for Tissue Regeneration pp 457–479Cite as

Thermosensitive Polymers for Controlled Delivery of Hormones

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Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 8))

Abstract

Thermosensitive polymeric systems, which remain as solution at room temperature and transform into gel at body temperature, have been extensively investigated for biomedical and pharmaceutical applications. The gel depot formed at the site of injection after the administration of an aqueous polymeric solution provides several benefits over the conventional delivery systems. These thermosensitive drug delivery systems are easy to formulate by simple mixing of therapeutic agents with the aqueous polymeric solutions, easy to administer by single injection, remain stable at the physiological conditions for a definite period of time, provide excellent stability for labile biomolecules such as proteins and peptides, and maintain the controlled and sustained release profile of the incorporated agents. Most of these systems are biodegradable and biocompatible, thereby eliminating the need of surgical explantation. This chapter discusses the classification of temperature sensitive systems, their synthesis and characterization procedures and provides a survey of recent literature on the in vitro and in vivo applications of thermosensitive polymers for controlled delivery of hormones.

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Abbreviations

AUC:

Area under the curve

ATRP:

Atomic transfer radical polymerization

BE:

Butyl vinyl ether

BMA:

Butyl methacrylate

CD:

Circular dichroism

CDCl3 :

Deuterated chloroform

Cmax :

Maximum plasma concentration

CMC:

Critical micelle concentration

CMT:

Critical micelle temperature

DLS:

Dyanamic light scattering

DPH:

1,6-diphenyl-1,3,5-hexatriene

D2O:

Deuterated water

DMSO-d6 :

Deuterated dimethyl sulfoxide

DSC:

Differential scanning calorimetery

EGVE:

Ethylene glycol vinyl ether

FT-IR:

Fourier transform infrared spectroscopy

G-CSF:

Granulocyte colony stimulating factor

GLP:

Glucagon-like peptide

GPC:

Gel permeation chromatography

hGH:

Human growth hormone

HP-β-CD:

Hydroxypropyl-β-cyclodextrin

HPLC:

High performance liquid chromatography

IGF:

Insulin-like growth factor

ISO:

International organization of standardization

LA/GA:

Lactic acid/Glycolic acid

LCST:

Lower critical solution temperature

LNG:

Levonorgestrel

MALDI:

Matrix-assisted laser desorption/ionization

ME:

Methoxyestradiol

Mn :

Number average molecular weight

MPA:

Methyl prednisolone

MPEG:

Methoxy poly(ethylene glycol)

MTT:

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

Mw :

Weight average molecular weight

NIPAAm:

N-isopropyl acrylamide

NMR:

Nuclear magnetic resonance

PAGE:

Polyacrylamide gel electrophoresis

PDEAAM:

Poly (N, N′-diethylacrylamide)

PDI:

Polydispersity index

PEG:

Poly(ethylene glycol)

PEO:

Poly(ethylene oxide)

pGH:

Porcine growth hormone

PLA:

Poly(lactic acid)

PLGA:

Poly(dl-lactic acid-co-glycolic acid)

PNIPAAm:

Poly(N-isopropylacrylamide)

PPO:

Poly(propylene oxide)

RAFT:

Reversible addition-fragmentation chain transfer

sCT:

Salmon calcitonin

SD:

Sprague–Dawley

SEM:

Scanning electron microscopy

SLS:

Static light scattering

TEM:

Transmission electron microscopy

TMS:

Tetramethyl silane

TSN:

Testosterone

UV:

Ultraviolet

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Authors and Affiliations

  1. Novartis Biologics, Process Sciences and Production, Novartis Institutes for BioMedical Research, Inc, Cambridge, MA, 02139, USA

    Yu Tang

  2. Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences Dept# 2665, North Dakota State University, PO Box 6050, Sudro Hall Room 102A, Fargo, ND, 58108-6050, USA

    Mayura Oak, Rhishikesh Mandke, Buddhadev Layek, Gitanjali Sharma & Jagdish Singh

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  1. Yu Tang
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  1. Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, Tel Aviv, 69978, Israel

    Meital Zilberman

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Tang, Y., Oak, M., Mandke, R., Layek, B., Sharma, G., Singh, J. (2011). Thermosensitive Polymers for Controlled Delivery of Hormones. In: Zilberman, M. (eds) Active Implants and Scaffolds for Tissue Regeneration. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2011_65

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