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Mechanobiological Modelling of Angiogenesis: Impact on Tissue Engineering and Bone Regeneration

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Book cover Computational Modeling in Tissue Engineering

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 10))

Abstract

Angiogenesis is essential for complex biological phenomena such as tissue engineering and bone repair. The ability to heal in these processes strongly depends on the ability of new blood vessels to grow. Capillary growth and its impact on human health has been focus of intense research from an in vivo, in vitro and in silico perspective. In fact, over the last decade many mathematical models have been proposed to understand and simulate the vascular network. This review addresses the role of the vascular network in well defined and controlled processes such as wound healing or distraction osteogenesis and covers the connection between vascularization and bone, starting with the biology of vascular ingrowth, moving through its impact on tissue engineering and bone regeneration, and ending with repair. Furthermore, we also describe the most recent in-silico models proposed to simulate the vascular network within bone constructs. Finally, discrete as well as continuum approaches are analyzed from a computational perspective and applied to three distinct phenomena: wound healing, distraction osteogenesis and individual cell migration in 3D.

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Notes

  1. 1.

    The authors apologize any related reference with the present work which remained uncited along the text.

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Acknowledgments

This research was supported by the project part financed by the European Union (European Regional Development Fund) through the grant DPI 2009-14115-C03-01.

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of Seville, 41092, Seville, Spain

    Esther Reina-Romo & Jaime Domínguez

  2. Aragon Institute of Engineering Research (I3A), University of Zaragoza, C/María de Luna 5, Agustín de Betancourt Building, 50018, Zaragoza, Spain

    Clara Valero, Carlos Borau, Rafael Rey, Etelvina Javierre, María José Gómez-Benito & José Manuel García-Aznar

  3. Centro Universitario de la Defensa, Academia General Militar Ctra, Huesca s/n, 50090, Zaragoza, Spain

    Etelvina Javierre

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  1. Esther Reina-Romo
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Correspondence to Esther Reina-Romo .

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    Liesbet Geris

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Reina-Romo, E. et al. (2011). Mechanobiological Modelling of Angiogenesis: Impact on Tissue Engineering and Bone Regeneration. In: Geris, L. (eds) Computational Modeling in Tissue Engineering. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2011_111

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