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Cellular Mechanics of Acute Leukemia and Chemotherapy

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Cellular and Biomolecular Mechanics and Mechanobiology

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 4))

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Abstract

Cellular mechanics plays a major role in the pathophysiology of hematologic diseases, in which the alterations of biophysical properties of circulating blood cells influence vascular flow and contribute to vascular complications. In particular, the cellular mechanical alterations that occur in acute leukemia, cancer of blood cell precursors, may lead to life-threatening complications that result in microvascular compromise of vital organs such as the brain and lung. As such, pharmacological agents that modulate the cellular mechanics of leukemia cells have the potential to both improve and worsen the symptoms and outcome of these complications. Recent technological advances have provided the necessary tools to study leukemia, cancer of blood cell precursors, cellular mechanics and have vastly improved our understanding of the biophysical aspects of leukemia pathophysiology. In this chapter, we review studies from our laboratory and other researchers that focus on the interactions between cellular mechanics, pharmacological agents, and leukemia biology, and we also highlight the novel tools and techniques developed to conduct those experiments. These studies clearly stress the important role the nascent field of cellular mechanics will have in clinical medicine in the near future.

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References

  1. Abiko, T., Abiko, A., Clermont, A.C., Shoelson, B., Horio, N., Takahashi, J., Adamis, A.P., King, G.L., Bursell, S.E.: Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes, 52, 829–837 (2003)

    Google Scholar 

  2. Abkarian, M., Faivre, M., Stone, H.A.: High-speed microfluidic differential manometer for cellular-scale hydrodynamics. Proc. Natl. Acad. Sci. USA 103, 538–542 (2006)

    Google Scholar 

  3. Aprelev, A., Weng, W., Zakharov, M., Rotter, M., Yosmanovich, D., Kwong, S., Briehl, R.W, Ferrone, F.A.: Metastable polymerization of sickle hemoglobin in droplets. J. Mol. Biol. 369, 1170–1174 (2007)

    Google Scholar 

  4. Armstrong, M., Jr., Needham, D., Hatchell, D.L, Nunn, R.S.: Effect of pentoxifylline on the flow of polymorphonuclear leukocytes through a model capillary. Angiology 41, 253–262 (1990)

    Google Scholar 

  5. Bagge, U., Amundson, B, Lauritzen, C.: White blood cell deformability and plugging of skeletal muscle capillaries in hemorrhagic shock. Acta Physiol. Scand. 108, 159–163 (1980)

    Google Scholar 

  6. Bahra, P.S., Rainger, G.E., Wautier, J.L, Nash, G.B.: Effects of pentoxifylline on the different steps during adhesion and transendothelial migration of flowing neutrophils. Cell Biochem. Funct. 19, 249–257 (2001)

    Google Scholar 

  7. Barabino, G.A., McIntire, L.V., Eskin, S.G., Sears, D.A, Udden, M.: Endothelial cell interactions with sickle cell, sickle trait, mechanically injured, and normal erythrocytes under controlled flow. Blood 70, 152–157 (1987a)

    Google Scholar 

  8. Barabino, G.A., McIntire, L.V., Eskin, S.G., Sears, D.A, Udden, M.: Rheological studies of erythrocyte–endothelial cell interactions in sickle cell disease. Prog. Clin Biol. Res. 240, 113–127 (1987b)

    Google Scholar 

  9. Baskurt, O.K, Meiselman, H.J.: Hemodynamic effects of red blood cell aggregation. Indian J. Exp. Biol. 45, 25–31 (2007)

    Google Scholar 

  10. Betticher, D.C., Keller, H., Maly, F.E, Reinhart, W.H.: The effect of endotoxin and tumour necrosis factor on erythrocyte and leucocyte deformability in vitro. Br. J. Haematol. 83, 130–137 (1993)

    Google Scholar 

  11. Bi, K.H., Jiang, G.S.: Relationship between cytokines and leukocytosis in patients with APL induced by all-trans retinoic acid or arsenic trioxide. Cell Mol. Immunol. 3, 421–427 (2006)

    Google Scholar 

  12. Binnig, G., Quate, C.F, Gerber, C.: Atomic force microscope. Phys. Rev. Lett. 56, 930–933 (1986)

    Google Scholar 

  13. Bransky, A., Korin, N., Nemirovski, Y, Dinnar, U.: An automated cell analysis sensing system based on a microfabricated rheoscope for the study of red blood cells physiology. Biosens. Bioelectron. 22, 165–169 (2006)

    Google Scholar 

  14. Brown, D.C., Tsuji, H., Larson, R.S.: All-trans retinoic acid regulates adhesion mechanism and transmigration of the acute promyelocytic leukaemia cell line NB-4 under physiologic flow. Br. J. Haematol. 107, 86–98 (1999)

    Google Scholar 

  15. Bruynzeel, I., van der Raaij, L.M., Willemze, R, Stoof, T.J.: Pentoxifylline inhibits human T-cell adhesion to dermal endothelial cells. Arch. Dermatol. Res. 289, 189–193 (1997)

    Google Scholar 

  16. Bunin, N.J, Pui, C.H.: Differing complications of hyperleukocytosis in children with acute lymphoblastic or acute nonlymphoblastic leukemia. J. Clin. Oncol. 3, 1590–1595 (1985)

    Google Scholar 

  17. Chibber, R., Ben-Mahmud, B.M., Chibber, S, Kohner, E.M.: Leukocytes in diabetic retinopathy. Curr. Diabetes Rev. 3, 3–14 (2007)

    Google Scholar 

  18. Chien, S., Sung, K.L., Schmid-Schonbein, G.W., Skalak, R., Schmalzer, E.A, Usami, S.: Rheology of leukocytes. Ann. N. Y. Acad. Sci. 516, 333–347 (1987)

    Google Scholar 

  19. Clermont, A.C, Bursell, S.E.: Retinal blood flow in diabetes. Microcirculation 14, 49–61 (2007)

    Google Scholar 

  20. Coimbra, R., Melbostad, H., Loomis, W., Porcides, R.D., Wolf, P., Tobar, M, Hoyt, D.B.: LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression. J. Trauma 60, 115–125 (2006)

    Google Scholar 

  21. Davey, H.M, Kell, D.B.: Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses. Microbiol. Rev. 60, 641–696 (1996)

    Google Scholar 

  22. De Rossi, G., Tenca, C., Cerruti, G., Favre, A., Zarcone, D., Tabilio, A., Mauro, F.R., Annino, L, Grossi, C.E.: Adhesion molecule expression on B-cells from acute and chronic lymphoid leukemias. Leuk. Lymphoma 16, 31–36 (1994)

    Google Scholar 

  23. Deree, J., Lall, R., Melbostad, H., Loomis, W., Hoyt, D.B, Coimbra, R.: Pentoxifylline attenuates stored blood-induced inflammation: a new perspective on an old problem. Surgery 140, 186–191 (2006)

    Google Scholar 

  24. Deree, J., Martins, J., de Campos, T., Putnam, J.G., Loomis, W.H., Wolf, P, Coimbra, R.: Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock. J. Surg. Res. 143, 99–108 (2007)

    Google Scholar 

  25. Discher, D.E., Janmey, P, Wang, Y.L.: Tissue cells feel and respond to the stiffness of their substrate. Science 310, 1139–1143 (2005)

    Google Scholar 

  26. Downing, J.R, Shannon, K.M.: Acute leukemia: a pediatric perspective. Cancer Cell 2, 437–445 (2002)

    Google Scholar 

  27. Drost, E.M., Kassabian, G., Meiselman, H.J., Gelmont, D, Fisher, T.C.: Increased rigidity and priming of polymorphonuclear leukocytes in sepsis. Am. J. Respir. Crit. Care Med. 159, 1696–1702 (1999)

    Google Scholar 

  28. Dubois C, Schlageter MH, de Gentile A, Balitrand N, Toubert ME, Krawice I, Fenaux P, Castaigne S, Najean Y, Degos L, et al.: Modulation of IL-8, IL-1 beta, and G-CSF secretion by all-trans retinoic acid in acute promyelocytic leukemia. Leukemia 8, 1750–1757 (1994)

    Google Scholar 

  29. Eaton, W.A, Hofrichter, J.: The biophysics of sickle cell hydroxyurea therapy. Science 268, 1142–1143 (1995)

    Google Scholar 

  30. Engler, A.J., Sen, S., Sweeney, H.L, Discher, D.E.: Matrix elasticity directs stem cell lineage specification. Cell 126, 677–689 (2006)

    Google Scholar 

  31. Estlin, E.J., Yule, S.M, Lowis, S.P.: Consolidation therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of cytosine arabinoside, epipodophyllotoxins and cyclophosphamide. Cancer Treat. Rev. 27, 339–350 (2001)

    Google Scholar 

  32. Frenette, P.S.: Sickle cell vaso-occlusion: multistep and multicellular paradigm. Curr. Opin. Hematol. 9, 101–106 (2002)

    Google Scholar 

  33. Fung, Y.C.: Biomechanics: Circulation. Springer, New York (1997)

    Google Scholar 

  34. Gifford, S.C., Derganc, J., Shevkoplyas, S.S., Yoshida, T, Bitensky, M.W.: A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence. Br. J. Haematol. 135, 395–404 (2006)

    Google Scholar 

  35. Gifford, S.C., Frank, M.G., Derganc, J., Gabel, C., Austin, R.H., Yoshida, T, Bitensky, M.W.: Parallel microchannel-based measurements of individual erythrocyte areas and volumes. Biophys. J. 84, 623–633 (2003)

    Google Scholar 

  36. Goddette, D.W, Frieden, C.: Actin polymerization. The mechanism of action of cytochalasin D. J. Biol. Chem. 261, 15974–15980 (1986)

    Google Scholar 

  37. Gonzalez-Amaro, R., Portales-Perez, D., Baranda, L., Redondo, J.M., Martinez-Martinez, S., Yanez-Mo, M., Garcia-Vicuna, R., Cabanas, C, Sanchez-Madrid, F.: Pentoxifylline inhibits adhesion and activation of human T lymphocytes. J. Immunol. 161, 65–72 (1998)

    Google Scholar 

  38. Grzanka, A.: Actin distribution patterns in HL-60 leukemia cells treated with etoposide. Acta Histochem. 103, 453–464 (2001)

    Google Scholar 

  39. Grzanka, A., Grzanka, D, Orlikowska, M.: Cytoskeletal reorganization during process of apoptosis induced by cytostatic drugs in K-562 and HL-60 leukemia cell lines. Biochem. Pharmacol. 66, 1611–1617 (2003)

    Google Scholar 

  40. Grzanka, A., Grzanka, D, Orlikowska, M.: Fluorescence and ultrastructural localization of actin distribution patterns in the nucleus of HL-60 and K-562 cell lines treated with cytostatic drugs. Oncol. Rep. 11, 765–770 (2004)

    Google Scholar 

  41. Grzanka, A., Grzanka, D., Zuryn, A., Grzanka, A.A, Safiejko-Mroczka, B.: Reorganization of actin in K-562 and HL-60 cells treated with taxol. Neoplasma 53, 56–61 (2006)

    Google Scholar 

  42. Guck, J., Ananthakrishnan, R., Mahmood, H., Moon, T.J., Cunningham, C.C., Käs, J.: The optical stretcher: a novel laser tool to micromanipulate cells. Biophys. J. 81, 767–84 (2001)

    Google Scholar 

  43. Hallows, K.R, Frank, R.S.: Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells. Biorheology 29, 295–309 (1992)

    Google Scholar 

  44. Hertz, H.: Über die Berühung fester elastischer Körper. J. Reine Angew. Math. 92, 156–171 (1882)

    Google Scholar 

  45. Hessler, J.A., Budor, A., Putchakayala, K., Mecke, A., Rieger, D., Banaszak Holl, M.M., Orr, B.G., Bielinska, A., Beals, J, Baker, J., Jr.: Atomic force microscopy study of early morphological changes during apoptosis. Langmuir 21, 9280–9286 (2005)

    Google Scholar 

  46. Hutchinson, R.J., Gaynon, P.S., Sather, H., Bertolone, S.J., Cooper, H.A., Tannous, R., Wells, L.M., Heerema, N.A., Sailer, S, Trigg, M.E.: Intensification of therapy for children with lower-risk acute lymphoblastic leukemia: long-term follow-up of patients treated on Children’s Cancer Group Trial 1881. J. Clin. Oncol. 21, 1790–1797 (2003)

    Google Scholar 

  47. Irish, J.M., Kotecha, N, Nolan, G.P.: Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Nat. Rev. Cancer 6, 146–155 (2006)

    Google Scholar 

  48. Kimby, E., Nygren, P, Glimelius, B. A systematic overview of chemotherapy effects in acute myeloid leukaemia. Acta Oncol. 40, 231–252 (2001)

    Google Scholar 

  49. Lam, W.A., Rosenbluth, M.J., Fletcher, D.A.: Increased leukaemia cell stiffness is associated with symptoms of leucostasis in paediatric acute lymphoblastic leukaemia. Br. J. Haematol. 142, 497–501 (2008)

    Google Scholar 

  50. Lam, W.A., Rosenbluth, M.J, Fletcher, D.A.: Chemotherapy exposure increases leukemia cell stiffness. Blood 109, 3505–3508 (2007)

    Google Scholar 

  51. Lang, F., Ritter, M., Gamper, N., Huber, S., Fillon, S., Tanneur, V., Lepple-Wienhues, A., Szabo, I, Gulbins, E.: Cell volume in the regulation of cell proliferation and apoptotic cell death. Cell Physiol. Biochem. 10, 417–428 (2000)

    Google Scholar 

  52. Lassiter, T.F.: Medications used to prevent adhesion and clotting. Lippincotts Prim Care Pract. 4, 619–632 (quiz 633–615) (2000)

    Google Scholar 

  53. Lautenschläger F, Paschke S, Schinkinger S, Bruel A, Beil M, Guck J.: The regulatory role of cell mechanics for migration of differentiating myeloid cells. Proc. Natl. Acad. Sci. USA 106, 15696–701 (2009)

    Google Scholar 

  54. Lee, W.G., Bang, H., Yun, H., Lee, J., Park, J., Kim, J.K., Chung, S., Cho, K., Chung, C., Han, D.C, Chang, J.K.: On-chip erythrocyte deformability test under optical pressure. Lab Chip 7, 516–519 (2007)

    Google Scholar 

  55. Levee, M.G., Dabrowska, M.I., Lelli, J.L., Jr, Hinshaw, D.B.: Actin polymerization and depolymerization during apoptosis in HL-60 cells. Am. J. Physiol. 271, C1981–1992 (1996)

    Google Scholar 

  56. Lichtman, M.A.: Cellular deformability during maturation of the myeloblast. Possible role in marrow egress. N. Engl. J. Med. 283, 943–948 (1970)

    Google Scholar 

  57. Lichtman, M.A.: Rheology of leukocytes, leukocyte suspensions, and blood in leukemia. J. Clin. Invest. 52, 350–358 (1973a)

    Google Scholar 

  58. Lichtman, M.A., Heal, J, Rowe, J.M. Hyperleukocytic leukaemia: rheological and clinical features and management. Bailliere’s Clin. Haematol. 1, 725–746 (1987)

    Google Scholar 

  59. Lichtman, M.A, Rowe, J.M.: Hyperleukocytic leukemias: rheological, clinical, and therapeutic considerations. Blood 60, 279–283 (1982)

    Google Scholar 

  60. Lincoln, B., Wottawah, F., Schinkinger, S., Ebert, S, Guck, J.: High-throughput rheological measurements with an optical stretcher. Methods Cell Biol. 83, 397–423 (2007)

    Google Scholar 

  61. Linderkamp, O., Pöschl, J, Ruef, P.: Blood cell deformation in neonates who have sepsis. Neoreviews 7, e517–e523 (2006)

    Google Scholar 

  62. Lipowsky, H.H.: Microvascular rheology and hemodynamics. Microcirculation 12, 5–15 (2005)

    Google Scholar 

  63. Lokich, J.J, Moloney, W.C.: Fatal pulmonary leukostasis following treatment in acute myelogenous leukemia. Arch. Intern. Med. 130, 759–762 (1972)

    Google Scholar 

  64. Lowe, E.J. , Pui, C.H., Hancock, M.L., Geiger, T.L., Khan, R.B. & Sandlund, J.T.: Early complications in children with acute lymphoblastic leukemia presenting with hyperleukocytosis. Pediatr Blood Cancer, 45, 10-15 (2005)

    Google Scholar 

  65. MacKintosh, F.C., Käs, J., Janmey, P.A.: Elasticity of semiflexible biopolymer networks. Phys. Rev. Lett. 75, 4425–4428 (1995)

    Google Scholar 

  66. Michetti, C., Coimbra, R., Hoyt, D.B., Loomis, W., Junger, W, Wolf, P.: Pentoxifylline reduces acute lung injury in chronic endotoxemia. J. Surg. Res. 115, 92–99 (2003)

    Google Scholar 

  67. Mielcarek, M., Sperling, C., Schrappe, M., Meyer, U., Riehm, H, Ludwig, W.D.: Expression of intercellular adhesion molecule 1 (ICAM-1) in childhood acute lymphoblastic leukaemia: correlation with clinical features and outcome. Br. J. Haematol. 96, 301–307 (1997)

    Google Scholar 

  68. Moricke, A., Reiter, A., Zimmermann, M., Gadner, H., Stanulla, M., Dordelmann, M., Loning, L., Beier, R., Ludwig, W.D., Ratei, R., Harbott, J., Boos, J., Mann, G., Niggli, F., Feldges, A., Henze, G., Welte, K., Beck, J.D., Klingebiel, T., Niemeyer, C., Zintl, F., Bode, U., Urban, C., Wehinger, H., Niethammer, D., Riehm, H, Schrappe, M.: Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. Blood (2008)

    Google Scholar 

  69. Mustjoki, S., Alitalo, R., Elonen, E., Carpen, O., Gahmberg, C.G, Vaheri, A.: Intercellular adhesion molecule-1 in extravasation of normal mononuclear and leukaemia cells. Br. J. Haematol. 113, 989–1000 (2001)

    Google Scholar 

  70. Myers, T.J., Cole, S.R., Klatsky, A.U, Hild, D.H.: Respiratory failure due to pulmonary leukostasis following chemotherapy of acute nonlymphocytic leukemia. Cancer 51, 1808–1813 (1983)

    Google Scholar 

  71. Neuner, P., Klosner, G., Pourmojib, M., Knobler, R, Schwarz, T.: Pentoxifylline in vivo and in vitro down-regulates the expression of the intercellular adhesion molecule-1 in monocytes. Immunology 90, 435–439 (1997)

    Google Scholar 

  72. Ng, L., Hung, H.H., Sprunt, A., Chubinskaya, S., Ortiz, C, Grodzinsky, A.: Nanomechanical properties of individual chondrocytes and their developing growth factor-stimulated pericellular matrix. J. Biomech. 40, 1011–1023 (2007)

    Google Scholar 

  73. Nolan, G.P.: Deeper insights into hematological oncology disorders via single-cell phospho-signaling analysis. Hematology Am. Soc. Hematol. Educ. Program. 509, 123–127 (2006)

    Google Scholar 

  74. Novotny, J.R., Muller-Beissenhirtz, H., Herget-Rosenthal, S., Kribben, A, Duhrsen, U.: Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. Eur. J. Haematol. 74, 501–510 (2005)

    Google Scholar 

  75. Novotny, J.R., Nuckel, H, Duhrsen, U.: Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. Eur. J. Haematol. 76, 299–308 (2006)

    Google Scholar 

  76. Patatanian, E., Thompson, D.F.: Retinoic acid syndrome: a review. J. Clin. Pharm. Ther. 33,331–338 (2008)

    Google Scholar 

  77. Porcu, P., Cripe, L.D., Ng, E.W., Bhatia, S., Danielson, C.M., Orazi, A, McCarthy, L.J.: Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management. Leuk. Lymphoma 39, 1–18 (2000)

    Google Scholar 

  78. Porcu, P., Danielson, C.F., Orazi, A., Heerema, N.A., Gabig, T.G, McCarthy, L.J.: Therapeutic leukapheresis in hyperleucocytic leukaemias: lack of correlation between degree of cytoreduction and early mortality rate. Br. J. Haematol. 98, 433–436 (1997)

    Google Scholar 

  79. Porcu, P., Farag, S., Marcucci, G., Cataland, S.R., Kennedy, M.S, Bissell, M.: Leukocytoreduction for acute leukemia. Therapeutic apheresis: official journal of the International Society for Apheresis and the Japanese Society for Apheresis 6, 15–23 (2002)

    Google Scholar 

  80. Pui, C.H., Robison, L.L, Look, A.T.: Acute lymphoblastic leukaemia. Lancet 371, 1030–1043 (2008)

    Google Scholar 

  81. Pui, C.H., Sandlund, J.T., Pei, D., Campana, D., Rivera, G.K., Ribeiro, R.C., Rubnitz, J.E., Razzouk, B.I., Howard, S.C., Hudson, M.M., Cheng, C., Kun, L.E., Raimondi, S.C., Behm, F.G., Downing, J.R., Relling, M.V, Evans, W.E.: Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children’s Research Hospital. Blood 104, 2690–2696 (2004)

    Google Scholar 

  82. Radmacher, M.: Measuring the elastic properties of living cells by the atomic force microscope. Methods Cell Biol. 68, 67–90 (2002)

    Google Scholar 

  83. Radmacher, M., Fritz, M., Kacher, C.M., Cleveland, J.P, Hansma, P.K.: Measuring the viscoelastic properties of human platelets with the atomic force microscope. Biophys. J. 70, 556–567 (1996)

    Google Scholar 

  84. Ravindranath, Y., Chang, M., Steuber, C.P., Becton, D., Dahl, G., Civin, C., Camitta, B., Carroll, A., Raimondi, S.C, Weinstein, H.J.: Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19, 2101–2116 (2005)

    Google Scholar 

  85. Rheinhold, S.R, Lange, B.V.: Oncologic emergencies. In: Pizzo, P.A., Poplack, D.G. (eds.) Principles and Practice of Pediatric Oncology, pp. 1177–1203. Lippincott Williams & Wilkins, Philadelphia (2002)

    Google Scholar 

  86. Ritter, L.S., Wilson, D.S., Williams, S.K., Copeland, J.G, McDonagh, P.F.: Pentoxifylline reduces leukocyte retention in the coronary microcirculation early in reperfusion following ischemia. Int. J. Microcirc. Clin. Exp. 16, 170–179 (1996)

    Google Scholar 

  87. Rosenbluth, M.J., Lam, W.A, Fletcher, D.A.: Force microscopy of nonadherent cells: a comparison of leukemia cell deformability. Biophys. J. 90, 2994–3003 (2006)

    Google Scholar 

  88. Ruef, P., Poeschl, J.M., Simon, C., Altfelder, F., Craciun, E, Linderkamp, O.: Effect of activators and the phosphodiesterase inhibitors pentoxifylline and enoximone on the deformability of neutrophils in neonates and adults. Acta Paediatr. 93, 1288–1293 (2004)

    Google Scholar 

  89. Samlaska, C.P, Winfield, E.A.: Pentoxifylline. J. Am. Acad. Dermatol. 30, 603–621 (1994)

    Google Scholar 

  90. Schade, U.F. Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. Circ. Shock 31, 171–181 (1990)

    Google Scholar 

  91. Schmalzer, E.A, Chien, S. Filterability of subpopulations of leukocytes: effect of pentoxifylline. Blood 64, 542–546 (1984)

    Google Scholar 

  92. Seale, J., Delva, L., Renesto, P., Balitrand, N., Dombret, H., Scrobohaci, M.L., Degos, L., Paul, P., Chomienne, C.: All-trans retinoic acid rapidly decreases cathepsin G synthesis and mRNA expression in acute promyelocytic leukemia. Leukemia 10, 95–101 (1996)

    Google Scholar 

  93. Seiffge, D.: Pentoxifylline: its influence on the interaction of blood cells with the vessel wall. Atherosclerosis 131 Suppl, S27–S28 (1997)

    Google Scholar 

  94. Sharma, K.: Cellular deformability studies in leukemia. Physiol. Chem. Phys. Med. NMR 25, 293–297 (1993)

    Google Scholar 

  95. Skoutelis, A.T., Kaleridis, V., Athanassiou, G.M., Kokkinis, K.I., Missirlis, Y.F., Bassaris, H.P.: Neutrophil deformability in patients with sepsis, septic shock, and adult respiratory distress syndrome. Crit. Care Med. 28, 2355–2359 (2000a)

    Google Scholar 

  96. Skoutelis, A.T., Kaleridis, V.E., Goumenos, D.S., Athanassiou, G.M., Missirlis, Y.F., Vlachojannis, J.G., Bassaris, H.P.: Polymorphonuclear leukocyte rigidity is defective in patients with chronic renal failure. Nephrol. Dial. Transplant 15, 1788–1793 (2000b)

    Google Scholar 

  97. Soares, F.A., Landell, G.A., Cardoso, M.C.: Pulmonary leukostasis without hyperleukocytosis: a clinicopathologic study of 16 cases. Am. J. Hematol. 40, 28–32 (1992)

    Google Scholar 

  98. Somer, T., Meiselman, H.J.: Disorders of blood viscosity. Ann. Med. 25, 31–39 (1993)

    Google Scholar 

  99. Steinberg, M.H., Charm, S.E.: Effect of high concentrations of leukocytes on whole blood viscosity. Blood 38, 299–301 (1971)

    Google Scholar 

  100. Stucki, A., Rivier, A.S., Gikic, M., Monai, N., Schapira, M., Spertini, O.: Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. Blood 97, 2121–2129 (2001)

    Google Scholar 

  101. Tallman, M.S., Andersen, J.W., Schiffer, C.A., Appelbaum, F.R., Feusner, J.H., Woods, W.G., Ogden, A., Weinstein, H., Shepherd, L., Willman, C., Bloomfield, C.D., Rowe, J.M., Wiernik, P.H.: All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol. Blood 13, 4298–4302 (2002)

    Google Scholar 

  102. Suresh, S.: Biomechanics and biophysics of cancer cells. Acta Biomater. 3, 413–438 (2007)

    MathSciNet  Google Scholar 

  103. Tighe, D., Moss, R., Heath, M.F., Hynd, J., Bennett, E.D.: Pentoxifylline reduces pulmonary leucostasis and improves capillary patency in a rabbit peritonitis model. Circ. Shock 28, 159–164 (1989)

    Google Scholar 

  104. Tsukada, K., Sekizuka, E., Oshio, C., Minamitani, H.: Direct measurement of erythrocyte deformability in diabetes mellitus with a transparent microchannel capillary model and high-speed video camera system. Microvasc. Res. 61, 231–239 (2001)

    Google Scholar 

  105. Vanapalli, S.A., Duits, M.H., Mugele, F.: Microfluidics as a functional tool for cell mechanics. Biomicrofluidics, 3 12006 (2009)

    Google Scholar 

  106. Ventura, G.J., Hester, J.P., Smith, T.L., Keating, M.J.: Acute myeloblastic leukemia with hyperleukocytosis: risk factors for early mortality in induction. Am. J. Hematol. 27 34–37 (1988)

    Google Scholar 

  107. Ward, A., Clissold, S.P.: Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 34, 50–97 (1987)

    Google Scholar 

  108. Wurthner, J.U., Kohler, G., Behringer, D., Lindemann, A., Mertelsmann, R., Lubbert, M.: Leukostasis followed by hemorrhage complicating the initiation of chemotherapy in patients with acute myeloid leukemia and hyperleukocytosis: a clinicopathologic report of four cases. Cancer 85, 368–374 (1999)

    Google Scholar 

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Authors and Affiliations

  1. Department of Bioengineering, University of California, Berkeley, CA, 94720, USA

    Wilbur A. Lam & Daniel A. Fletcher

  2. Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, CA, 94143, USA

    Wilbur A. Lam

  3. Graduate Group in Biophysics, University of California, Berkeley, CA, 94720, USA

    Daniel A. Fletcher

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  1. Wilbur A. Lam
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  2. Daniel A. Fletcher
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Correspondence to Wilbur A. Lam .

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  1. Fac. Engineering, Dept. Biomedical Engineering, Tel Aviv University, Ramat Aviv, 69978, Israel

    Amit Gefen

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Lam, W.A., Fletcher, D.A. (2010). Cellular Mechanics of Acute Leukemia and Chemotherapy. In: Gefen, A. (eds) Cellular and Biomolecular Mechanics and Mechanobiology. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2010_27

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  • DOI: https://doi.org/10.1007/8415_2010_27

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