Abstract
Research interests in biomechanical modeling of the intracranial system and structural neurological disorders have increased in the last two decades. The lack of clarity on the physiology of the intracranial system has resulted in some disparities in these models. The aim of this chapter is to provide a thorough physiological background of the intracranial system, the mechanics of several types of structural neurological disorders that arise when the system is disturbed and outline the benefits in modeling these disorders. This chapter concludes by discussing some of the impending issues that need to be resolved in order to improve our understanding of a diseased intracranial system using computational models.
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References
Ateshian, G.A.: The role of interstitial fluid pressurization in articular cartilage lubrication. J. Biomech. 42(9), 1163–1176 (2009)
Bering, E.A.: Choroid plexus and arterial pulsation of cerebrospinal fluid; demonstration of the choroid plexuses as a cerebrospinal fluid pump. Am. Med. Assoc.: Arch. Neurol. Psychiatry 73(2), 165–172 (1955)
Berkouk, K., Carpenter, P.W., Lucey, A.D.: Pressure wave propagation in fluid-filled co-axial elastic tubes. Part 1: Basic theory. J. Biomech. Eng. 125(6), 852–856 (2003)
Bertram, C.D., Brodbelt, A.R., Stoodley, M.A.: The origins of syringomyelia: numerical models of fluid/structure interactions in the spinal cord. J. Biomech. Eng. 127(7), 1099–1109 (2005)
Bilston, L.E., Fletcher, D.F., Brodbelt, A.R., et al. Arterial pulsation-driven cerebrospinal fluid flow in the perivascular space: a computational model. Comput. Methods Biomech. Biomed. Eng. 6(4), 235–241 (2003)
Bilston, L.E., Fletcher, D.F., Stoodley, M.A.: Focal spinal arachnoiditis increases subarachnoid space pressure: a computational study. Clin. Biomech. (Bristol, Avon) 21(6), 579–584 (2006)
Bloomfield, I.G., Johnston, I.H., Bilston, L.E.: Effects of proteins, blood cells and glucose on the viscosity of cerebrospinal fluid. Pediatr. Neurosurg. 28(5), 246–251 (1998)
Bradley, W., Whittemore, A., Kortman, K., et al. Marked cerebrospinal fluid void: indicator of successful shunt in patients with suspected normal pressure hydrocephalus. Radiology 178, 459–466 (1991)
Bradley, W.G., Kortman, K.E., Burgoyne, B.: Flowing cerebrospinal fluid in normal and hydrocephalic states: appearance on MR images. Radiology 159(3), 611–616 (1986)
Brodbelt, A.R., Stoodley, M.A., Watling, A.M., et al.: Altered subarachnoid space compliance and fluid flow in an animal model of posttraumatic syringomyelia. Spine 28(20), E413–E419 (2003)
Carpenter, P.W., Berkouk, K., Lucey, A.D.: Pressure wave propagation in fluid-filled co-axial elastic tubes. Part 2: Mechanisms for the pathogenesis of syringomyelia. J. Biomech. Eng. 125(6), 857–863 (2003)
Cheng, S., Bilston, L.: Computational model of the cerebral ventricles in hydrocephalus. J. Biomech. Eng. 132(5), 054501 (2010)
Cheng, S., Jacobson, E., Bilston, L.E.: Models of the pulsatile hydrodynamics of cerebrospinal fluid flow in the normal and abnormal intracranial system. Comp. Methods Biomech. Biomed. Eng. 10(2), 151–157 (2007)
Cheng, S., Tan, K., Bilston, L.E.: The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles. J. Biomech. 43(3), 579–582 (2009)
Cserr, H.F.: Convection of Brain Interstitial Fluid. Raven Press, New York (1984)
Dandy, W.E., Blackfan, K.D.: Internal hydrocephalus. An experimental, clinical and pathological study. Am. J. Dis. Child. 8, 406–481 (1914)
Davson, H., Segal, M.B.: Physiology of the CSF and Blood-Brain Barrier. CRC Press, Boca Raton (1996)
Di Rocco, C., Pettorossi, V.E., Caldarelli, M., et al.: Communicating hydrocephalus induced by mechanically increased amplitude of the intraventricular cerebrospinal fluid pressure: experimental studies. Exp. Neurol. 59(1), 40–52 (1978)
DuBoulay, G., O’Connell, J., Currie, J., et al.: Further investigations on pulsatile movements in the cerebrospinal fluid pathways. Acta Radiol.: Diagn. 13, 496–523 (1972)
Dutta-Roy, T., Wittek, A., Miller, K.: Biomechanical modeling of normal pressure hydrocephalus. J. Biomech. 41(10), 2263–2271 (2008)
Enzmann, D.R., Pelc, N.J.: Normal flow patterns of intracranial and spinal cerebrospinal fluid defined with phase-contrast cine MR imaging. Radiology 178, 467–474 (1991)
Enzmann, D.R., Pelc, N.J.: Brain motion: measurement with phase-contrast MR imaging. Radiology 185, 653–660 (1992)
Feinberg, D.A., Mark, A.S.: Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging. Radiology 163(3), 793–799 (1987)
Fin, L., Grebe, R.: Three dimensional modeling of the cerebrospinal fluid dynamics and brain interactions in the aqueduct of sylvius. Comp. Methods Biomech. Biomed. Eng. 6(3), 163–170 (2003)
Friden, H.G., Ekstedt, J.: Volume/pressure relationship of the cerebrospinal space in humans. Neurosurgery 13(4), 351–366 (1983)
Greitz, D.: Cerebrospinal fluid circulation and associated intracranial dynamics. A radiological investigation using MR imaging and radionuclide cisternography. Acta Radiol. Suppl. 386, 1–23 (1993)
Greitz, D.: Radiological assessment of hydrocephalus: new theories and implications of therapy. Neurosurg. Rev. 27(3), 145–165 (2004)
Greitz, D., Hannerz, J.: A proposed model of cerebrospinal fluid circulation: observations with radionuclide cisternography. Am. J. Neuroradiol. 17(3), 431–438 (1996)
Greitz, D., Wirestam, R., Franck, A., et al.: Pulsatile brain movement and associated hydrodynamics studied by magnetic resonance phase imaging. The Monro-Kellie doctrine revisited. Neuroradiology 34(5), 370–380 (1992)
Hakim, S., Adams, R.D.: The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure: observations on cerebrospinal fluid hydrodynamics. J. Neurol. Sci. 2, 307–327 (1965)
Hakim, S., Venegas, J., Burton, J.: The physics of the cranial cavity, hydrocephalus and normal pressure hydrocephalus: mathematical interpretations and mathematical models. Surg. Neurol. 5, 187–210 (1976)
Heiss, J.D., Patronas, N., DeVroom, H.L., et al.: Elucidating the pathophysiology of syringomyelia. J. Neurosurg. 91(4), 553–562 (1999)
Howden, L., Giddings, D., Power, H., et al.: Three-dimensional cerebrospinal fluid flow within the human ventricular system. Comp. Methods Biomech. Biomed. Eng. 11(2), 123–133 (2008)
Ishii, M., Suzuki, S., Julow, J.: Subarachnoid haemorrhage and communicating hydrocephalus. Scanning electron microscope observations. Acta Neurochir. (Wien) 50, 265–272 (1979)
Jacobson, E.E., Fletcher, D.F., Morgan, M.K., et al.: Fluid dynamics of the cerebral aqueduct. Pediatr. Neurosurg. 24, 229–236 (1996)
Jagdish, C., Hulme, A., Cooper, R.: Intracranial pressure in patients with dementia and communicating hydrocephalus. J. Neurosurg. 40, 376–380 (1974)
Julow, J., Ishii, M., Iwabuchi, T.: Scanning electron microscope of subarachnoid macrophages and subarachnoid haemorrhage and their possible role in the formation of subarachnoid fibrosis. Acta Neurochir. (Wien) 50, 273–279 (1979)
Kim, D.S., Choi, J.U., Huh, R., et al.: Quantitative assessment of cerebrospinal fluid hydrodynamics using a phase-contrast cine MR image in hydrocephalus. Childs Nerv. Syst. 15(9), 461–467 (1999)
Klose, U., Strik, C., Kiefer, C., et al.: Detection of a relation between respiration and CSF pulsation with an echoplanar technique. J. Magn. Reson. Imaging 11(7), 438–444 (2000)
Kurtcuoglu, V., Poulikakos, D., Ventikos, Y.: Computational modeling of the mechanical behavior of the cerebrospinal fluid system. J. Biomech. Eng. 127(2), 264–269 (2005)
Kurtcuoglu, V., Soellinger, M., Summers, P., et al.: Computational investigation of subject-specific cerebrospinal fluid flow in the third ventricle and aqueduct of Sylvius. J. Biomech. 40(6), 1235–1245 (2007)
Leech, P., Miller, J.D.: Intracranial volume-pressure relationships during experimental brain compression in primates. 1. Pressure response to changes in ventricular volume. J. Neurol. Neurosurg. Psychiatry 37, 1093–1098 (1974)
Linninger, A.A., Tsakiris, C., Zhu, D.C., et al.: Pulsatile cerebrospinal fluid dynamics in the human brain. IEEE Trans. Biomed. Eng. 52(4), 557–565 (2005)
Linninger, A.A., Xenos, M., Zhu, D.C., et al. Cerebrospinal fluid flow in the normal and hydrocephalic human brain. IEEE Trans. Biomed. Eng. 54(2), 291–302 (2007)
Lofgren, J., Essen, C.V., Zwetnow, N.: The pressure volume curve of the cerebrospinal fluid space in dogs. Acta Neurol. Scand. 49, 557–574 (1973)
Milhorat, T.H.: Failure of choroid plexectomy as treatment of hydrocephalus. Surg. Gynecol. Obstet. 139, 505–508 (1974)
Milhorat, T.H., Hammock, M.K., Fenstermacher, J.D., et al.: Cerebrospinal fluid production by the choroid plexus and brain. Science 173(994), 330–332 (1971)
Mow, V.C., Kuei, S.C., Lai, W.M., et al.: Biphasic creep and stress relaxation of articular cartilage in compression: theory and experiments. J. Biomech. Eng. 102, 73–83 (1980)
Nagashima, T., Tamaki, N., Matsumoto, S., et al.: Biomechanics of hydrocephalus: a new theoretical model. Neurosurgery 21, 898–904 (1987)
Naidich, T.P., Epstein, F., Lin, J.P., et al.: Evaluation of pediatric hydrocephalus by computed tomography. Radiology 119(2), 337–345 (1976)
Nilsson, C., Stahlberg, F., Thomsen, C., et al.: Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging. Am. J. Physiol. 262, R20–R24 (1992)
O’Connell, J.E.: Cerebrospinal fluid mechanics. Proc. R. Soc. Med. 63(5), 507–518 (1970)
Oldfield, E.H., Muraszko, K., Shawker, T.H., et al.: Pathophysiology of syringomyelia associated with Chiari I malformation of the cerebellar tonsils. Implications for diagnosis and treatment. J. Neurosurg. 80(1), 3–15 (1994)
Patwardhan, R.V., Nanda, A.: Implanted ventricular shunts in the united states: the billion-dollar-a year cost of hydrocephalus treatment. Neurosurgery 56(1), 139–144 (2005)
Pena, A., Bolton, M.D., Whitehouse, H., et al.: Effects of brain ventricular shape on periventricular biomechanics: a finite-element analysis. Neurosurgery 45(1), 107–118 (1999)
Penn, R.D., Bacus, J.W.: The brain as a sponge: a computed tomographic look at Hakim’s hypothesis. Neurosurgery 14(6), 670–675 (1984)
Schroth, G., Klose, U.: Cerebrospinal fluid flow. I. Physiology of cardiac-related pulsation. Neuroradiology 35(1), 1–9 (1992)
Sivaloganathan, S., Tenti, G., Drake, J.M.: Mathematical pressure-volume models of the cerebrospinal fluid. Appl. Math. Comput. 94, 243–266 (1998)
Sklar, F.H., Diehl, J.T., Beyer, C.W.: Brain elasticity changes with ventriculomegaly. J. Neurosurg. 53, 173–179 (1980)
Sklar, F.H., Elashvili, I.: The pressure-volume function of brain elasticity. Physiological considerations and clinical applications. J. Neurosurg. 47(5), 670–679 (1977)
Stephensen, H., Tisell, M., Wikkelso, C.: There is no transmantle pressure gradient in communicating or noncommunicating hydrocephalus. Neurosurgery 50(4), 763–771 (2002)
Struck, A.F., Haughton, V.M.: Idiopathic syringomyelia: phase-contrast MR of cerebrospinal fluid flow dynamics at level of foramen magnum. Radiology 253(1), 184–190 (2009)
Taylor, Z., Miller, K.: Reassessment of brain elasticity for analysis of biomechanisms of hydrocephalus. J. Biomech. 37(8), 1263–1269 (2004)
Tenti, G., Drake, J.M., Sivaloganathan, S.: Brain biomechanics: mathematical modeling of hydrocephalus. Neurol. Res. 22(1), 19–24 (2000)
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Cheng, S. (2010). Neural Tissue Biomechanics: Biomechanics and Models of Structural Neurological Disorders. In: Bilston, L. (eds) Neural Tissue Biomechanics. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2010_14
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DOI: https://doi.org/10.1007/8415_2010_14
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