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Revisiting Old Questions and New Approaches to Investigate the Fungal Cell Wall Construction

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The Fungal Cell Wall

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 425))

Abstract

The beginning of our understanding of the cell wall construction came from the work of talented biochemists in the 70–80’s. Then came the era of sequencing. Paradoxically, the accumulation of fungal genomes complicated rather than solved the mystery of cell wall construction, by revealing the involvement of a much higher number of proteins than originally thought. The situation has become even more complicated since it is now recognized that the cell wall is an organelle whose composition continuously evolves with the changes in the environment or with the age of the fungal cell. The use of new and sophisticated technologies to observe cell wall construction at an almost atomic scale should improve our knowledge of the cell wall construction. This essay will present some of the major and still unresolved questions to understand the fungal cell wall biosynthesis and some of these exciting futurist approaches.

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Authors and Affiliations

  1. Experimental Neuropathology Unit, Institut Pasteur, 25 rue du Docteur Roux, 75015, Paris, France

    Michael Blatzer

  2. Mycology Department, Institut Pasteur, 25 rue du Docteur Roux, 75015, Paris, France

    Anne Beauvais

  3. Architecture et Fonction des Macromolécules Biologiques, UMR 7257—CNRS & Aix-Marseille Université, 13288, Marseille cedex 9, France

    Bernard Henrissat

  4. Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

    Bernard Henrissat

  5. Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology Hellas (IMBB-FORTH), Heraklion, Greece

    Jean-Paul Latgé

Authors
  1. Michael Blatzer
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  2. Anne Beauvais
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  3. Bernard Henrissat
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  4. Jean-Paul Latgé
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Correspondence to Jean-Paul Latgé .

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  1. Foundation for Research and Technology-Hellas (FORTH), Institute of Molecular Biology and Technology, Heraklion, Crete, Greece

    Jean-Paul Latgé

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Blatzer, M., Beauvais, A., Henrissat, B., Latgé, JP. (2020). Revisiting Old Questions and New Approaches to Investigate the Fungal Cell Wall Construction. In: Latgé, JP. (eds) The Fungal Cell Wall . Current Topics in Microbiology and Immunology, vol 425. Springer, Cham. https://doi.org/10.1007/82_2020_209

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