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Exopolysaccharides and Biofilms

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The Fungal Cell Wall

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 425))

Abstract

During infection, many fungal pathogens form biofilms within tissues or on biomedical devices. The growth of fungi within biofilms increases dramatically their resistance to both immune defences and antifungal therapies. In the last twenty years, studies have begun to shed light on many of the steps involved in biofilm synthesis and composition, revealing new antifungal strategies. This chapter will focus on the biofilm exopolysaccharides produced by A. fumigatus and C. albicans, the two main causes of human fungal infections. We will review the current state of our understanding of the structure, biosynthesis, and role of exopolysaccharides in biofilm development and function with a view to identifying future strategies for prophylaxis and treatment of these devastating infections.

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Acknowledgements

I would like to thank Dr. Don Sheppard for is mentorship and review of the book chapter. I am also grateful to Josée Chabot, Ira Lacdao, Yazan Abu Yousef, and Ansh Goyal for their review of the different sections of the chapter.

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  1. Research Institute of the McGill University Health Centre, Montreal, QC, H4A3J1, Canada

    François Le Mauff

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Correspondence to François Le Mauff .

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  1. Foundation for Research and Technology-Hellas (FORTH), Institute of Molecular Biology and Technology, Heraklion, Crete, Greece

    Jean-Paul Latgé

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Le Mauff, F. (2020). Exopolysaccharides and Biofilms. In: Latgé, JP. (eds) The Fungal Cell Wall . Current Topics in Microbiology and Immunology, vol 425. Springer, Cham. https://doi.org/10.1007/82_2020_199

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