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Fc Receptors in Antimicrobial Protection

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Fc Mediated Activity of Antibodies

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 423))

Abstract

Antibodies are the key effector molecules of the humoral immune system providing long-term protective immunity against a wide range of pathogens and regulating immune responses. Traditionally, antibody-mediated protection against microbes was thought to be mainly a result of neutralizing Fab–antigen interaction; however, an increasing number of studies show the importance of proper FcR engagement for the protective capacity of antimicrobial antibodies. In this chapter, we review FcR-mediated effector functions contributing to antimicrobial protection in a direct and indirect manner. Furthermore, we highlight recent findings about the important role of Fc–FcR interactions for antimicrobial protection in vivo and provide examples demonstrating the crucial role of proper FcR engagement for antibody-mediated protection against viruses, bacteria, fungi, and parasites.

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  1. Department of Microbiology & Immunology, School of Medicine, Emory University, 1510 Clifton Road, Atlanta, GA, USA

    Andreas Wieland & Rafi Ahmed

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  1. Andreas Wieland
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  2. Rafi Ahmed
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Correspondence to Andreas Wieland .

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  1. Department of Leonard Wagner Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY, USA

    Jeffrey V. Ravetch

  2. Department of Biology, University of Erlangen-Nürnberg, Erlangen, Bayern, Germany

    Falk Nimmerjahn

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Wieland, A., Ahmed, R. (2019). Fc Receptors in Antimicrobial Protection. In: Ravetch, J., Nimmerjahn, F. (eds) Fc Mediated Activity of Antibodies. Current Topics in Microbiology and Immunology, vol 423. Springer, Cham. https://doi.org/10.1007/82_2019_154

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