Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens

  • Tao PengEmail author
  • Howard C. HangEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 420)


Protein fatty-acylation describes the covalent modification of protein with fatty acids during or after translation. Chemical proteomic profiling methods have provided new opportunities to explore protein fatty-acylation in microbial pathogens. Recent studies suggest that protein fatty-acylation is essential to survival and pathogenesis of eukaryotic pathogens such as parasites and fungi. Moreover, fatty-acylation in host cells can be exploited or manipulated by pathogenic bacteria. Herein, we first review the prevalent classes of fatty-acylation in microbial pathogens and the chemical proteomic profiling methods for their global analysis. We then summarize recent fatty-acylation profiling studies performed in eukaryotic pathogens and during bacterial infections, highlighting how they contribute to functional characterization of fatty-acylation under these contexts.


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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhenChina
  2. 2.Laboratory of Chemical Biology and Microbial PathogenesisThe Rockefeller UniversityNew YorkUSA

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