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Tim-3, Lag-3, and TIGIT

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Book cover Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 410))

Abstract

Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens. T cells express a module of co-inhibitory receptors, which display great diversity in expression, structure, and function. Here, we focus on the co-inhibitory receptors Tim-3, Lag-3, and TIGIT and how they regulate T cell function, maintenance of self-tolerance, their role in regulating ongoing T cell responses at peripheral tissues, and their synergistic effects in regulating autoimmunity and antitumor responses.

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Acknowledgements

This work was supported by the Swiss National Science Foundation (PP00P3_150663/1 to N.J.), the European Research Council (677200 to N.J.), and the National Institutes of Health (P01 AI073748, P01 NS076410, P01 AI039671, and R01 NS045937 to V.K.K.).

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  1. Institute for Experimental Immunology, University of Zurich, Zurich, Switzerland

    Nicole Joller

  2. Harvard Medical School and Brigham & Women’s Hospital, Evergrande Center for Immunologic Diseases, Boston, MA, USA

    Vijay K. Kuchroo

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Correspondence to Vijay K. Kuchroo .

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  1. Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan

    Akihiko Yoshimura

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Joller, N., Kuchroo, V.K. (2017). Tim-3, Lag-3, and TIGIT. In: Yoshimura, A. (eds) Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity. Current Topics in Microbiology and Immunology, vol 410. Springer, Cham. https://doi.org/10.1007/82_2017_62

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