Abstract
Non-coding RNAs (ncRNAs) play essential roles in multiple aspects of the life cycles of herpesviruses and contribute to lifelong persistence of herpesviruses within their respective hosts. In this chapter, we discuss the types of ncRNAs produced by the different herpesvirus families during infection, some of the cellular ncRNAs manipulated by these viruses, and the overall contributions of ncRNAs to the viral life cycle, influence on the host environment, and pathogenesis.
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Abbreviations
- KSHV:
-
Kaposi’s sarcoma associated herpesvirus
- HVS:
-
Herpesvirus saimiri
- HCMV:
-
Human Cytomegalovirus
- RhCMV:
-
Rhesus Cytomegalovirus
- MCMV:
-
Mouse Cytomegalovirus
- RCMV:
-
Rat Cytomegalovirus
- EBV:
-
Epstein Barr virus
- LCV:
-
Lymphocryptovirus
- HSV:
-
Herpes simplex virus
- miRNA:
-
MicroRNA
- snoRNA:
-
Small nucleolar RNA
- sisRNA:
-
Stable intronic sequence RNA
- ncRNA:
-
Non-coding RNA
- EBERs:
-
EBV-encoded RNAs
- BARTs:
-
BamHI A rightward transcripts
- BHRF1:
-
BamHI right forward 1
- PAN:
-
Polyadenylated nuclear RNA
- LAT:
-
Latency-associated transcript
- HSURs:
-
HVS Sm class U RNAs
- UTR:
-
Untranslated region
- LMP:
-
Latent membrane protein
- RTA:
-
Replication and transcription activator protein
- EBNA:
-
EBV nuclear antigen
- RNA:
-
Ribonucleic acid
- RISC:
-
RNA-induced silencing complex
- PAR-CLIP:
-
Photoactivatable ribonucleoside enhanced cross-linking and immunoprecipitation
- HITS-CLIP:
-
High throughput sequencing of RNA isolated by cross-linking and immunoprecipitation
- ChIRP:
-
Chromatin isolation by RNA purification
- CHART:
-
Capture hybridization analysis of RNA targets
- TF:
-
Transcription factor
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Acknowledgements
We thank the past and present members of Jay Nelson’s laboratory at VGTI for discussions, and apologize to the many scientists whose work we could not mention due to space limitations. This work was supported by a Pathway to Independence Award CA175181 from the National Cancer Institute to R.L.S. Support for M.H. comes from NIH grant AI21640.
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Hancock, M.H., Skalsky, R.L. (2017). Roles of Non-coding RNAs During Herpesvirus Infection. In: Tripp, R., Tompkins, S. (eds) Roles of Host Gene and Non-coding RNA Expression in Virus Infection. Current Topics in Microbiology and Immunology, vol 419. Springer, Cham. https://doi.org/10.1007/82_2017_31
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DOI: https://doi.org/10.1007/82_2017_31
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