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IgM and Its Receptors and Binding Proteins pp 25–45Cite as

Authentic IgM Fc Receptor (FcμR)

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 408))

Abstract

Since the bona fide Fc receptor for IgM antibody (FcµR) was identified eight years ago, much progress has been made in defining its biochemical nature, cellular distribution, and effector function. However, there are clearly conflicting results, especially about the cellular distribution and function of murine FcµR. In this short article, we will discuss recent findings from us and other investigators along with our interpretations and comments that may help to resolve the existing puzzles and should open new avenues of investigation.

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Acknowledgements

Studies cited in this chapter have been done with many valuable colleagues and collaborators including Stephen Barnes, Randall S. Davis, G. Larry Gartland, Sudhir Gupta, Shozo Izui, Dewitt Jones, Dong-Won Kang, John F. Kearney, Toshio Kitamura, Yoshiki Kubagawa, Fu Jun Li, Matthew K. McCollum, Tomoko Motohashi, Tetsuya Nakamura, Hiroshi Ohno, Satoshi Oka, Tatsuharu Ohno, Sheila K. Sanders, Yusuke Suzuki, Eiji Takayama, Ikuko Torii, Ji-Yang Wang, Landon Wilson, and Zilu Zhu. HK expresses his immense gratitude to his respected mentor Dr. Max D. Cooper.

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Authors and Affiliations

  1. Deutsches Rheuma-Forschungszentrum in Berlin, 10117, Berlin, Germany

    Hiromi Kubagawa, Christopher M. Skopnik, Jakob Zimmermann, Pawel Durek, Hyun-Dong Chang & Andreas Radbruch

  2. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, 90095, USA

    Esther Yoo

  3. Brookwood Medical Center, Birmingham, USA

    Luigi F. Bertoli

  4. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35209, USA

    Kazuhito Honjo

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  1. Hiromi Kubagawa
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Correspondence to Hiromi Kubagawa .

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  1. Deutsches Rheumaforschungszentrum, Berlin, Germany

    Hiromi Kubagawa

  2. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Peter D. Burrows

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Kubagawa, H. et al. (2017). Authentic IgM Fc Receptor (FcμR). In: Kubagawa, H., Burrows, P. (eds) IgM and Its Receptors and Binding Proteins. Current Topics in Microbiology and Immunology, vol 408. Springer, Cham. https://doi.org/10.1007/82_2017_23

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