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Ecology of Filoviruses

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Marburg- and Ebolaviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 411))

Abstract

Filoviruses can cause severe and often fatal disease in humans. To date, there have been 47 outbreaks resulting in more than 31,500 cases of human illness and over 13,200 reported deaths. Since their discovery, researchers from many scientific disciplines have worked to better understand the natural history of these deadly viruses. Citing original research wherever possible, this chapter reviews laboratory and field-based studies on filovirus ecology and summarizes efforts to identify where filoviruses persist in nature, how virus is transmitted to other animals and ultimately, what drivers cause spillover to human beings. Furthermore, this chapter discusses concepts on what constitutes a reservoir host and highlights challenges encountered while conducting research on filovirus ecology, particularly field-based investigations.

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The findings and conclusions in this review are those of the authors and not necessarily those of the Centers for Disease Control and Prevention.

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Authors and Affiliations

  1. Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd. Ne, Atlanta, GA, USA

    Brian R. Amman, Stuart T. Nichol & Jonathan S. Towner

  2. Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, PO Box X323, Arcadia, Pretoria, 0007, RSA

    Robert Swanepoel

  3. Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks, Athens, GA, USA

    Jonathan S. Towner

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  1. Brian R. Amman
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  2. Robert Swanepoel
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  3. Stuart T. Nichol
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  4. Jonathan S. Towner
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Correspondence to Brian R. Amman or Jonathan S. Towner .

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Editors and Affiliations

  1. Boston University School of Medicine , Boston, Massachusetts, USA

    Elke Mühlberger

  2. NIAID, National Institutes of Health NIAID, Frederick, Maryland, USA

    Lisa L. Hensley

  3. Centers for Disease Control & Prevention, Atlanta, Georgia, USA

    Jonathan S. Towner

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Amman, B.R., Swanepoel, R., Nichol, S.T., Towner, J.S. (2017). Ecology of Filoviruses. In: Mühlberger, E., Hensley, L., Towner, J. (eds) Marburg- and Ebolaviruses. Current Topics in Microbiology and Immunology, vol 411. Springer, Cham. https://doi.org/10.1007/82_2017_10

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