Abstract
Entomopathogenic nematodes are important organisms for the biological control of insect pests and excellent models for dissecting the molecular basis of the insect immune response against both the nematode parasites and their mutualistic bacteria. Previous research involving the use of various insects has found distinct differences in the number and nature of immune mechanisms that are activated in response to entomopathogenic nematode parasites containing or lacking their associated bacteria. Recent studies using model insects have started to reveal the identity of certain molecules with potential anti-nematode or antibacterial activity as well as the molecular components that nematodes and their bacteria employ to evade or defeat the insect immune system. Identification and characterization of the genes that regulate the insect immune response to nematode–bacteria complexes will contribute significantly to the development of improved practices to control insects of agricultural and medical importance, and potentially nematode parasites that infect mammals, perhaps even humans.
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Acknowledgments
The authors wish to thank members of the Eleftherianos laboratory for fruitful discussions. Research in the authors’ laboratory is funded by grants from the National Institutes of Health—National Institute of Allergy and Infectious Diseases (1R01AI110675 and 1R21AI109517) and the Columbian College of Arts and Sciences at George Washington University.
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Eleftherianos, I., Shokal, U., Yadav, S., Kenney, E., Maldonado, T. (2016). Insect Immunity to Entomopathogenic Nematodes and Their Mutualistic Bacteria. In: ffrench-Constant, R. (eds) The Molecular Biology of Photorhabdus Bacteria . Current Topics in Microbiology and Immunology, vol 402. Springer, Cham. https://doi.org/10.1007/82_2016_52
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