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Emergence and Spread of Antimicrobial Resistance: Recent Insights from Bacterial Population Genomics

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Book cover How to Overcome the Antibiotic Crisis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 398))

Abstract

Driven by progress of DNA sequencing technologies, recent population genomics studies have revealed that several bacterial pathogens constitute ‘measurably evolving populations’. As a consequence, it was possible to reconstruct the emergence and spatial spread of drug-resistant bacteria on the basis of temporally structured samples of bacterial genome sequences. Based on currently available data, some general inferences can be drawn across different bacterial species as follows:

  1. (1)

    Resistance to various antibiotics evolved years to decades earlier than had been anticipated on the basis of epidemiological surveillance data alone.

  2. (2)

    Resistance traits are more rapidly acquired than lost and commonly persist in bacterial populations for decades.

  3. (3)

    Global populations of drug-resistant pathogens are dominated by very few clones, yet the features enabling such spreading success have not been revealed, aside from antibiotic resistance.

  4. (4)

    Whole-genome sequencing proved very effective at identifying bacterial isolates as parts of the same transmission networks.

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Authors and Affiliations

  1. DZIF Group on Microbial Genome Research, Leibniz Institute DSMZ, Braunschweig, Germany

    Ulrich Nübel

  2. Technical University Braunschweig, Braunschweig, Germany

    Ulrich Nübel

  3. German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig, Germany

    Ulrich Nübel

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  1. Ulrich Nübel
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  1. Department Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Niedersachsen, Germany

    Marc Stadler

  2. Dept. Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Niedersachsen, Germany

    Petra Dersch

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Nübel, U. (2016). Emergence and Spread of Antimicrobial Resistance: Recent Insights from Bacterial Population Genomics. In: Stadler, M., Dersch, P. (eds) How to Overcome the Antibiotic Crisis . Current Topics in Microbiology and Immunology, vol 398. Springer, Cham. https://doi.org/10.1007/82_2016_505

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