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Synthesis of Antibiotics

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How to Overcome the Antibiotic Crisis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 398))

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Abstract

The synthesis of β-lactams, tetracyclines, and erythromycins as three of the major families of antibiotics will be described herein. We will describe why these antibiotics were the ultimate synthetic targets in the past and how modern synthetic organic chemistry has evolved to address these challenges with new, improved strategies and methods. An additional aspect we would like to highlight here is the fact that these first syntheses had to be particularly creative as most of the modern synthetic methods were not available at that time, or were developed in the course of these syntheses.

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Authors and Affiliations

  1. Institute for Organic Chemistry and Centre of Biomolecular Drug Research, Leibniz Universität Hannover, Schneiderberg 1B, 30167, Hannover, Germany

    Markus Kalesse, Andreas Böhm, Andi Kipper & Vanessa Wandelt

  2. Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Brunswick, Germany

    Markus Kalesse

Authors
  1. Markus Kalesse
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  2. Andreas Böhm
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  3. Andi Kipper
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  4. Vanessa Wandelt
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Correspondence to Markus Kalesse .

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Editors and Affiliations

  1. Department Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Niedersachsen, Germany

    Marc Stadler

  2. Dept. Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Niedersachsen, Germany

    Petra Dersch

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Kalesse, M., Böhm, A., Kipper, A., Wandelt, V. (2016). Synthesis of Antibiotics. In: Stadler, M., Dersch, P. (eds) How to Overcome the Antibiotic Crisis . Current Topics in Microbiology and Immunology, vol 398. Springer, Cham. https://doi.org/10.1007/82_2016_502

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