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Epidemiology of Staphylococcus aureus Nasal Carriage Patterns in the Community

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How to Overcome the Antibiotic Crisis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 398))

Abstract

Staphylococcus aureus (S. aureus) is a Gram-positive opportunistic pathogen that colonizes frequently and asymptomatically the anterior nares of humans and animals. It can cause different kinds of infections and is considered to be an important nosocomial pathogen. Nasal carriage of S. aureus can be permanent or intermittent and may build the reservoir for autogenous infections and cross-transmission to other individuals. Most of the studies on the epidemiology of S. aureus performed in the past were focused on the emergence and dissemination of methicillin-resistant Staphylococcus aureus (MRSA) in healthcare settings. There are, however, a number of more recent epidemiological studies have aimed at analysing carriage patterns over time in the community settings providing new insights on risk factors for colonization and important data for the development of strategies to prevent infections. This chapter aims to give a review of current epidemiological studies on S. aureus carriage patterns in the general community and put them into perspective with recent, yet unpublished, investigations on the S. aureus epidemiology in the general population in northern Germany.

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Acknowledgments

We are thankful to all staff of the epidemiology department for organizational support in the study. We are indebted to all study participants for their participation over six months. We also want to thank Ms. Angie Massicotte, from Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada for her review and valuable suggestions which have led to significant improvements in the presentation of this manuscript.

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Authors and Affiliations

  1. Department of Epidemiology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Brunswick, Germany

    Jaishri Mehraj, Manas K. Akmatov & Gérard Krause

  2. Hannover Medical School, Hannover, Germany

    Jaishri Mehraj & Gérard Krause

  3. The Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany

    Wolfgang Witte, Franziska Layer & Guido Werner

  4. TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

    Manas K. Akmatov

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  1. Jaishri Mehraj
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  2. Wolfgang Witte
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  3. Manas K. Akmatov
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  4. Franziska Layer
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  5. Guido Werner
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  6. Gérard Krause
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Correspondence to Gérard Krause .

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  1. Department Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Niedersachsen, Germany

    Marc Stadler

  2. Dept. Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Niedersachsen, Germany

    Petra Dersch

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Mehraj, J., Witte, W., Akmatov, M.K., Layer, F., Werner, G., Krause, G. (2016). Epidemiology of Staphylococcus aureus Nasal Carriage Patterns in the Community. In: Stadler, M., Dersch, P. (eds) How to Overcome the Antibiotic Crisis . Current Topics in Microbiology and Immunology, vol 398. Springer, Cham. https://doi.org/10.1007/82_2016_497

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