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Prix Fixe: Efferocytosis as a Four-Course Meal

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Apoptotic and Non-apoptotic Cell Death

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 403))

Abstract

During development, stress, infection, or normal homeostasis, billions of cells die on a daily basis, and the responsibility of clearing these cellular corpses lies with the phagocytes of innate immune system. This process, termed efferocytosis , is critical for the prevention of inflammation and autoimmunity , as well as modulation of the adaptive immune response. Defective clearance of dead cells is characteristic of many human autoimmune or autoinflammatory disorders, such as systemic lupus erythematosus (SLE), atherosclerosis, and diabetes. The mechanisms that phagocytes employ to sense, engulf, and process dead cells for an appropriate immune response have been an area of great interest. However, insight into novel mechanisms of programmed cell death , such as necroptosis, has shed light on the fact that while the diner (or phagocyte) is important, the meal itself (the type of dead cell) can play a crucial role in shaping the pursuant immune response.

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  1. Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA

    Jennifer Martinez

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  1. Biochemistry & Immunology, WPI Immunology frontier research center, Osaka University, Osaka, Japan

    Shigekazu Nagata

  2. Department of Biochemistry, Toho University School of Medicine, Tokyo, Tokyo, Japan

    Hiroyasu Nakano

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Martinez, J. (2015). Prix Fixe: Efferocytosis as a Four-Course Meal. In: Nagata, S., Nakano, H. (eds) Apoptotic and Non-apoptotic Cell Death. Current Topics in Microbiology and Immunology, vol 403. Springer, Cham. https://doi.org/10.1007/82_2015_467

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